Results 141 to 150 of about 6,382 (183)

Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions

Cell Death and Disease
Obesity is a global epidemic characterized by chronic low-grade inflammation and metabolic dysfunction, with adipose tissue playing a pivotal role in these processes.
Juliette Tokgozoglu, Valeria Pistorio, Mirko Minini, Pierre-Antoine Soret, Virginie Steunou, Jean-Louis Delaunay, Julien Castel, Serge Luquet, Ivan Nemazanyy, Carine Beaupère, Laetitia Dinard, Tatiana Ledent, Aurore L’honoré, Sara Lemoinne, Chantal Housset, Philippe Lesnik, Vlad Ratziu, Bruno Fève, Tounsia Aït-Slimane, Axelle Cadoret, Nicolas Chignard, Jérémie Gautheron   +21 more
doaj   +1 more source

Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL

Cell Death & Disease
AbstractNecroptosis is a kind of programmed cell death that causes the release of damage-associated molecular patterns and inflammatory disease including skin inflammation. Activation of receptor-interacting serine/threonine kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL) is the hallmark of tumour necrosis factor α (TNF ...
Jingyi Li, Xingfeng Liu, Yuanyuan Liu, Fangmin Huang, Jiankun Liang, Yingying Lin, Fen Hu, Jianting Feng, Zeteng Han, Yushi Chen, Xuan Chen, Qiaofa Lin, Lanqin Wu, Lisheng Li   +13 more
openaire   +3 more sources

MLKL‒OPTN axis regulates herpesvirus‐induced neurological sequelae

Clinical and Translational Medicine
Background Herpes simplex virus‐1 (HSV‐1) infections are lifelong and linked to neurological diseases such as multiple sclerosis (MS), yet the underlying mechanisms in the host remain poorly understood.
Ilina Bhattacharya, Rashmi Kadam, Tejabhiram Yadavalli, Chandrashekhar D. Patil, Hemant Borase, Ipsita Volety, Sergey Kalinin, Douglas L. Feinstein, Henry C. Tseng, Deepak Shukla   +9 more
doaj   +1 more source

MLKL wt Allele [PDF]

, 2020
openaire   +1 more source

LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL

Cell Death and Disease
Plasma membrane accumulation of phosphorylated mixed lineage kinase domain-like (MLKL) is a hallmark of necroptosis, leading to membrane rupture and inflammatory cell death.
Nadine Weinelt, Kaja Nicole Wächtershäuser, Gulustan Celik, Birte Jeiler, Isabelle Gollin, Laura Zein, Sonja Smith, Geoffroy Andrieux, Tonmoy Das, Jens Roedig, Leonard Feist, Björn Rotter, Melanie Boerries, Francesco Pampaloni, Sjoerd J. L. van Wijk   +14 more
doaj   +1 more source

MLKL et les reliques de la mort

médecine/sciences, 2023
Gwennan André-Grégoire, Julie Gavard
openaire   +1 more source

MLKL in liver parenchymal cells promotes liver cancer in murine metabolic dysfunction-associated steatotic liver disease

Cell Death and Disease
The rising prevalence of hepatocellular carcinoma (HCC) in the last decade is mostly attributable to the growing epidemic of metabolic dysfunction-associated steatotic liver diseases (MASLD).
Ghiles Imerzoukene, Ghania Hounana Kara-Ali, Céline Heitz-Marchaland, Thibaut Larcher, Mélanie Simoes Eugénio, Annaïg Hamon, Aurore Bidon, Gevorg Ghukasyan, Laurence Dubreil, Nicolas Loiseau, Sarah Dion, Céline Raguenes-Nicol, Claire Piquet-Pellorce, Michel Samson, Marie-Thérèse Dimanche-Boitrel, Jacques Le Seyec   +15 more
doaj   +1 more source

The neurotoxicant PCB-95 by increasing the neuronal transcriptional repressor REST down-regulates caspase-8 and increases Ripk1, Ripk3 and MLKL expression determining necroptotic neuronal death [PDF]

, 2017
Canzoniero, Lmt, Di Renzo, G, Formisano, L., Guida, N, Laudati, G, Mascolo, L, Molinaro, P, Montuori, P, Serani, A   +8 more
core   +1 more source

Homoharringtonine, a clinically approved anti-leukemia drug, sensitizes tumor cells for TRAIL-induced necroptosis [PDF]

, 2015
Dieter Adam, Holger Kalthoff, Johannes Plenge, Justyna Sosna, Stephan Philipp   +4 more
core   +1 more source

3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants [PDF]

, 2015
Aggeliki-Stefania Basogianni, Athanassios D. Velentzas, Dimitrios J. Stravopodis, Efthimios Paronis, Ema Anastasiadou, Eumorphia G. Konstantakou, Evangelos Balafas, Gerassimos E. Voutsinas, Konstantinos N. Syrigos, Nikolaos Kostomitsopoulos   +9 more
core   +1 more source