Results 141 to 150 of about 13,017 (220)

Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions

Cell Death and Disease
Obesity is a global epidemic characterized by chronic low-grade inflammation and metabolic dysfunction, with adipose tissue playing a pivotal role in these processes.
Juliette Tokgozoglu, Valeria Pistorio, Mirko Minini, Pierre-Antoine Soret, Virginie Steunou, Jean-Louis Delaunay, Julien Castel, Serge Luquet, Ivan Nemazanyy, Carine Beaupère, Laetitia Dinard, Tatiana Ledent, Aurore L’honoré, Sara Lemoinne, Chantal Housset, Philippe Lesnik, Vlad Ratziu, Bruno Fève, Tounsia Aït-Slimane, Axelle Cadoret, Nicolas Chignard, Jérémie Gautheron   +21 more
doaj   +1 more source

Hepatocyte MLKL drives obesity-driven hepatocellular carcinoma progression via mitochondrial dysfunction independent of necroptosis in MASLD

Background and Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of hepatocellular carcinoma (HCC), particularly in obesity, yet mechanisms linking hepatocyte dysfunction to
Satoshi Matsuzaki, Albert Tran, Phoebe Ohene-Marfo, Chao Jiang, Kara Kneuper, Megan John, Surendra Shukla, Sabira Mohammed, Jonathan D Wren, Tae Gyu Oh, Sathyaseelan S. Deepa, Bo Hagy, Julianne N. Hoang, Michael Kinter, Kenneth Humphries, Randal J. May, Constantin Georgescu, Willard M Freeman, Shylesh Bhaskaran, Courtney Houchen, Kevin Pham, Chinthalapally V. Rao   +21 more
core   +1 more source

Crotonylome profiling identifies MLKL crotonylation in lupus nephritis associated with RAB1A-mTOR signalling and autophagy changes in tubular epithelial cells. [PDF]

Lupus Sci Med
Lu RL, Meng SH, Peng QZ, Chen Y, Yang X, Liu HY, Zheng FP, Liu D, Hong X.   +8 more
europepmc   +1 more source

LILRB4 Attenuates Ischemic Brain Injury by Inhibiting Microglial Necroptosis via a RIPK3-Dependent Mechanism. [PDF]

Glia
Hu J, Zhang M, Liu P, Chen Y, Meng H, Xia S, Bao X, Xu Y, Chen Y.   +8 more
europepmc   +1 more source

Structural characterization of PAMK and its protective effect against thymic necroptosis in goslings. [PDF]

Vet Q
Li W, Lu B, Zhou X, Pan S, Wei J, Li B, Cao N, Huang Y, Liu W, Fu X, Tian Y, Xu D.   +11 more
europepmc   +1 more source

TNFAIP3 and MLKL-Related Necroptosis Signatures in Liver Transplant Ischemia-Reperfusion Injury: Integrated Transcriptomic and Experimental Evidence. [PDF]

J Inflamm Res
Pu W, Shi J, Jiang J, Xu B, Wang Y, Hu J, Sun G, Han C, Chen H.   +8 more
europepmc   +1 more source

Reduced endothelial TAK1 impairs vascular integrity in cerebral small vessel disease <i>via</i> the RIPK1-MLKL signalling pathway. [PDF]

Stroke Vasc Neurol
Yang J, Xiao C, Yi M, Zhou K, Xu X, Fan Y.   +5 more
europepmc   +1 more source

LncRNA DLX6-AS1 promotes necroptosis through PI3K/AKT/mTOR signaling pathway in myocardial ischemia/reperfusion injury mice. [PDF]

Sci Rep
Su Y, Mu L, Wang L, Li T, Zhang Q, Zhang J.   +5 more
europepmc   +1 more source

Foot-and-mouth disease virus non-structural protein 3D induces necroptosis through interaction with RIPK3 in PK-15 and BHK-21 cells. [PDF]

Front Vet Sci
Zhang Z, Yin J, Zhang M, He X, Zhao W, Ji G, Bao S.   +6 more
europepmc   +1 more source

Systematic genetic analysis of GSDMD, GSDME, and MLKL in PANoptosis. [PDF]

J Biol Chem
Indari O, Giri P, Tweedell RE, Kanneganti TD.   +3 more
europepmc   +1 more source