Results 31 to 40 of about 12,009 (206)

Angiotensin II triggers RIPK3-MLKL-mediated necroptosis by activating the Fas/FasL signaling pathway in renal tubular cells - Fig 5 [PDF]

, 2020
Disruption of RIP1, RIP3, and MLKL suppresses the necroptosis of HK-2 cells induced by Ang II (A) TUNEL-stained (green fluorescence) HK-2 cells in each treatment group were costained to detect RIP3 (red fluorescence) and the nucleus (DAPI, blue ...
Hongwang Cui (2826101), Yongjun Zhu (2794957), Liangbao Zhong (8538618), Xiaoyan Li (117291), Feng Ye (173489), Jie Lv (235936), Guojun Li (16705)   +6 more
core   +1 more source

Acylation of MLKL impacts its function in necroptosis

ACS Chemical Biology, 2023
ABSTRACT Mixed lineage kinase domain-like (MLKL) is a key signaling protein of necroptosis. Upon activation by phosphorylation, MLKL translocates to the plasma membrane and induces membrane permeabilization which contributes to the necroptosis-associated inflammation. Membrane binding of MLKL is initially initiated by
Apoorva J. Pradhan, Shweta Chitkara, Ricardo X. Ramirez, Viviana Monje-Galvan, Yasemin Sancak, G. Ekin Atilla-Gokcumen   +5 more
openaire   +3 more sources

Evolutionary divergence of the necroptosis effector MLKL [PDF]

Cell Death & Differentiation, 2016
The pseudokinase, MLKL (mixed-lineage kinase domain-like), is the most terminal obligatory component of the necroptosis cell death pathway known. Phosphorylation of the MLKL pseudokinase domain by the protein kinase, receptor interacting protein kinase-3 (RIPK3), is known to be the key step in MLKL activation.
M C, Tanzer, I, Matti, J M, Hildebrand, S N, Young, A, Wardak, A, Tripaydonis, E J, Petrie, A L, Mildenhall, D L, Vaux, J E, Vince, P E, Czabotar, J, Silke, J M, Murphy   +12 more
openaire   +2 more sources

Molecular Insights into the Mechanism of Necroptosis: The Necrosome As a Potential Therapeutic Target

Cells, 2019
Necroptosis, or regulated necrosis, is an important type of programmed cell death in addition to apoptosis. Necroptosis induction leads to cell membrane disruption, inflammation and vascularization.
Jing Chen, Renate Kos, Johan Garssen, Frank Redegeld   +3 more
doaj   +1 more source

MLKL-mediated necroptosis is a target for cardiac protection in mouse models of type-1 diabetes

Cardiovascular Diabetology, 2022
Background Cardiomyocyte death contributes to cardiac pathology of diabetes. Studies have shown that the RIPK3/MLKL necroptosis signaling is activated in diabetic hearts. Deletion of RIPK3 was reported to attenuate myocardial injury and heart dysfunction
Ting Cao, Rui Ni, Weimin Ding, Xiaoyun Ji, Lan Li, Guangneng Liao, Yanrong Lu, Guo-Chang Fan, Zhuxu Zhang, Tianqing Peng   +9 more
doaj   +1 more source

Angiotensin II triggers RIPK3-MLKL-mediated necroptosis by activating the Fas/FasL signaling pathway in renal tubular cells [PDF]

, 2020
Our earlier studies proved that RIPK3-mediated necroptosis might be an important mode of renal tubular cell death in rats with chronic renal injury and the necroptotic cell death can be triggered by tumor necrosis factor-α (TNF-α) in vitro, but the ...
Hongwang Cui (2826101), Yongjun Zhu (2794957), Liangbao Zhong, Guojun Li, Xiaoyan Li (117291), Guojun Li (16705), Yongjun Zhu, Xiaoyan Li, Hongwang Cui, Liangbao Zhong (8538618), Jie Lv, Feng Ye (173489), Jie Lv (235936), Feng Ye   +13 more
core   +1 more source

Detection of necroptosis by phospho-MLKL immunohistochemical labeling

STAR Protocols, 2021
TNF-induced necroptosis is involved in many physiological and pathological processes. Phospho-MLKL is a hallmark of necroptosis. Cecum is a sensitive organ with extensive necroptosis responses to TNF in vivo. Here, taking advantage of commercially available mouse TNF and easily accessible reagents and materials, we systematically provide a detailed and
Peng He, Tingting Ai, Zhang-Hua Yang, Jianfeng Wu, Jiahuai Han   +4 more
openaire   +3 more sources

Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats

Journal of Neuroinflammation, 2021
Background Our previous study indicated that hypoxic preconditioning reduced receptor interacting protein (RIP) 3-mediated necroptotic neuronal death in hippocampal CA1 of adult rats after transient global cerebral ischemia (tGCI). Although mixed lineage
Lixuan Zhan, Xiaomei Lu, Wensheng Xu, Weiwen Sun, En Xu   +4 more
doaj   +1 more source

Necroptosis, The Double-Edged Sword and Its Therapeutic Implications in Cancer [PDF]

Archives of Pharmaceutical Sciences Ain Shams University
Necroptosis is a regulated cell death technique that eliminates cancer cells that are resistant to apoptosis, without requiring caspase. Necroptosis is implicated in several physiological and pathological processes.
Amer, Rana A., Kamal, Amany M., El-shemy, Reham A. A., El-Mesallamy, Hala O.   +3 more
doaj   +1 more source

MLKL: Functions beyond serving as the Executioner of Necroptosis

Theranostics, 2021
Recently, necroptosis, as a programmed cell death pathway, has drawn much attention as it has been implicated in multiple pathologies, especially in the field of inflammatory diseases. Pseudokinase mixed lineage kinase domain-like protein (MLKL) serves as a terminal-known obligate effector in the process of necroptosis.
Zhan, Chaoning, Huang, Minchun, Yang, Xiaojun, Hou, Jin   +3 more
openaire   +2 more sources