Results 31 to 40 of about 6,382 (183)
ESC Heart Failure, 2022 Aims The role of necroptosis in dilated cardiomyopathy (DCM) remains unclear. Here, we examined whether phosphorylation of mixed lineage kinase domain‐like protein (MLKL), an indispensable event for execution of necroptosis, is associated with the ...
Yugo Fujita +15 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Mixed lineage kinase like protein (MLKL) is a key mediator of necroptosis. While previous studies highlighted the important role of MLKL as one of the central regulators of brain damage against acute ischemic neuronal injury, how the activation of MLKL ...
Xian-Yong Zhou +8 more
doaj +1 more source
Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis [PDF]
, 2014 In human cells, the RIPK1-RIPK3-MLKL-PGAM5-Drp1 axis drives tumor necrosis factor (TNF)-induced necroptosis through mitochondrial fission, but whether this pathway is conserved among mammals is not known. To answer this question, we analyzed the presence
Baekelandt, V +13 more
core +3 more sources
Evolutionary divergence of the necroptosis effector MLKL [PDF]
Cell Death & Differentiation, 2016 The pseudokinase, MLKL (mixed-lineage kinase domain-like), is the most terminal obligatory component of the necroptosis cell death pathway known. Phosphorylation of the MLKL pseudokinase domain by the protein kinase, receptor interacting protein kinase-3 (RIPK3), is known to be the key step in MLKL activation.
M C, Tanzer +12 more
openaire +2 more sources
PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. [PDF]
, 2018 Necroptosis, a form of regulated necrotic cell death, is governed by RIP1/RIP3-mediated activation of MLKL. However, the signaling process leading to necroptotic death remains to be elucidated.
Chen, Dongshi +7 more
core +2 more sources
MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis
Cell Death & Differentiation, 2023 AbstractMixed lineage kinase-like protein (MLKL) forms amyloid-like polymers to promote necroptosis; however, the mechanism through which these polymers trigger cell death is not clear. We have determined that activated MLKL translocates to the lysosomal membrane during necroptosis induction.
Shuzhen Liu +6 more
openaire +2 more sources
Detection of necroptosis by phospho-MLKL immunohistochemical labeling
STAR Protocols, 2021 TNF-induced necroptosis is involved in many physiological and pathological processes. Phospho-MLKL is a hallmark of necroptosis. Cecum is a sensitive organ with extensive necroptosis responses to TNF in vivo. Here, taking advantage of commercially available mouse TNF and easily accessible reagents and materials, we systematically provide a detailed and
Peng He +4 more
openaire +3 more sources
Cell Discovery, 2023 Mixed lineage kinase domain-like (MLKL) is widely accepted as an executioner of necroptosis, in which MLKL mediates necroptotic signaling and triggers cell death in a receptor-interacting protein kinase 3 (RIPK3)-dependent manner.
Xifei Jiang +24 more
doaj +1 more source
iScience, 2022 Summary: Despite intense research in understanding Clostridium perfringens (C. perfringens) pathogenesis, the mechanisms by which it is cleared from the host are largely unclarified. In C.
Yang Liu +14 more
doaj +1 more source
Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis. [PDF]
, 2018 Understanding the molecular signaling in programmed cell death is vital to a practical understanding of inflammation and immune cell function. Here we identify a previously unrecognized mechanism that functions to downregulate the necrosome, a central ...
A Degterev +67 more
core +2 more sources