Results 11 to 20 of about 881 (68)

Molecular Insights into the Mechanism of Necroptosis: The Necrosome As a Potential Therapeutic Target

Cells, 2019
Necroptosis, or regulated necrosis, is an important type of programmed cell death in addition to apoptosis. Necroptosis induction leads to cell membrane disruption, inflammation and vascularization.
Jing Chen, Renate Kos, Johan Garssen, Frank Redegeld   +3 more
doaj   +1 more source

MLKL-mediated necroptosis is a target for cardiac protection in mouse models of type-1 diabetes

Cardiovascular Diabetology, 2022
Background Cardiomyocyte death contributes to cardiac pathology of diabetes. Studies have shown that the RIPK3/MLKL necroptosis signaling is activated in diabetic hearts. Deletion of RIPK3 was reported to attenuate myocardial injury and heart dysfunction
Ting Cao, Rui Ni, Weimin Ding, Xiaoyun Ji, Lan Li, Guangneng Liao, Yanrong Lu, Guo-Chang Fan, Zhuxu Zhang, Tianqing Peng   +9 more
doaj   +1 more source

Necroptosis, The Double-Edged Sword and Its Therapeutic Implications in Cancer [PDF]

Archives of Pharmaceutical Sciences Ain Shams University
Necroptosis is a regulated cell death technique that eliminates cancer cells that are resistant to apoptosis, without requiring caspase. Necroptosis is implicated in several physiological and pathological processes.
Amer, Rana A., Kamal, Amany M., El-shemy, Reham A. A., El-Mesallamy, Hala O.   +3 more
doaj   +1 more source

Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats

Journal of Neuroinflammation, 2021
Background Our previous study indicated that hypoxic preconditioning reduced receptor interacting protein (RIP) 3-mediated necroptotic neuronal death in hippocampal CA1 of adult rats after transient global cerebral ischemia (tGCI). Although mixed lineage
Lixuan Zhan, Xiaomei Lu, Wensheng Xu, Weiwen Sun, En Xu   +4 more
doaj   +1 more source

MLKL and CaMKII Are Involved in RIPK3-Mediated Smooth Muscle Cell Necroptosis

Cells, 2021
Receptor interacting protein kinase 3 (RIPK3)-mediated smooth muscle cell (SMC) necroptosis has been shown to contribute to the pathogenesis of abdominal aortic aneurysms (AAAs).
Ting Zhou, Elise DeRoo, Huan Yang, Amelia Stranz, Qiwei Wang, Roman Ginnan, Harold A. Singer, Bo Liu   +7 more
doaj   +1 more source

A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma

Cell Discovery, 2023
Mixed lineage kinase domain-like (MLKL) is widely accepted as an executioner of necroptosis, in which MLKL mediates necroptotic signaling and triggers cell death in a receptor-interacting protein kinase 3 (RIPK3)-dependent manner.
Xifei Jiang, Wenjia Deng, Siyao Tao, Zheng Tang, Yuehong Chen, Mengxin Tian, Ting Wang, Chenyang Tao, Yize Li, Yuan Fang, Congying Pu, Jun Gao, Xiaomin Wang, Weifeng Qu, Xiameng Gai, Zhenbin Ding, Yixian Fu, Ying Zheng, Siyuwei Cao, Jian Zhou, Min Huang, Weiren Liu, Jun Xu, Jia Fan, Yinghong Shi   +24 more
doaj   +1 more source

Mixed lineage kinase-like protein protects against Clostridium perfringens infection by enhancing NLRP3 inflammasome-extracellular traps axis

iScience, 2022
Summary: Despite intense research in understanding Clostridium perfringens (C. perfringens) pathogenesis, the mechanisms by which it is cleared from the host are largely unclarified. In C.
Yang Liu, Li-Hua Xing, Fen-Xin Li, Na Wang, Yu-Ze Ma, Jian-Wei Li, Yu-Jing Wu, Jing Liang, Yu-Xin Lei, Xue-Yin Wang, Fan-Hua Meng, Yong-Jun Yang, Guang-Peng Li, Xiao Wang, Shui-Xing Yu   +14 more
doaj   +1 more source

Structural Insights into RIP3-Mediated Necroptotic Signaling

Cell Reports, 2013
RIP3 is an essential upstream kinase in necroptosis. The pseudokinase MLKL functions as a substrate of RIP3 to mediate downstream signaling. The molecular mechanism by which RIP3 recognizes and phosphorylates MLKL remains unknown.
Tian Xie, Wei Peng, Chuangye Yan, Jianping Wu, Xinqi Gong, Yigong Shi   +5 more
doaj   +1 more source

Enhanced nuclear localization of phosphorylated MLKL predicts adverse events in patients with dilated cardiomyopathy

ESC Heart Failure, 2022
Aims The role of necroptosis in dilated cardiomyopathy (DCM) remains unclear. Here, we examined whether phosphorylation of mixed lineage kinase domain‐like protein (MLKL), an indispensable event for execution of necroptosis, is associated with the ...
Yugo Fujita, Toshiyuki Yano, Hiromitsu Kanamori, Daigo Nagahara, Atsuko Muranaka, Hidemichi Kouzu, Atsushi Mochizuki, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Naoyuki Kamiyama, Marenao Tanaka, Atsushi Kuno, Masaya Tanno, Tetsuji Miura   +15 more
doaj   +1 more source

The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes

iScience, 2022
Summary: Receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins are key regulators of necroptosis, a highly pro-inflammatory mode of cell death, which has been involved in various human diseases.
Julie Magusto, Carine Beaupère, Marta B. Afonso, Martine Auclair, Jean-Louis Delaunay, Pierre-Antoine Soret, Gilles Courtois, Tounsia Aït-Slimane, Chantal Housset, Isabelle Jéru, Bruno Fève, Vlad Ratziu, Cecilia M.P. Rodrigues, Jérémie Gautheron   +13 more
doaj   +1 more source