Results 11 to 20 of about 13,017 (220)

Oligomerization-driven MLKL ubiquitylation antagonizes necroptosis [PDF]

The EMBO Journal, 2021
Mixed lineage kinase domain-like (MLKL) is the executioner in the caspase-independent form of programmed cell death called necroptosis. Receptor-interacting serine/threonine protein kinase 3 (RIPK3) phosphorylates MLKL, triggering MLKL oligomerization ...
Wang, X, Liu, Z, Dagley, LF, Fitzgibbon, C, Stafford, CA, Silke, J, Hildebrand, JM, Bankovacki, A, Shield-Artin, K, Howitt, J, Nachbur, U, Komander, D, Webb, AI, Garnish, SE, Young, SN, Tang, M, Murphy, JM   +16 more
core   +4 more sources

PROTACs Targeting MLKL Protect Cells from Necroptosis

Journal of Medicinal Chemistry, 2023
Mixed Lineage Kinase domain-Like pseudokinase (MLKL) is implicated in a broad range of diseases due to its role as the ultimate effector of necroptosis and has therefore emerged as an attractive drug target.
Dieter W. Hamprecht (3033684), Lara Perryman (373284), Richard J. Payne (401410), Oliver H. Rathje (16750498)   +3 more
core   +4 more sources

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis [PDF]

Nature Communications, 2021
Mixed Lineage Kinase Domain-Like (MLKL) pseudokinase is phosphorylated by RIPK3 kinase prior to cell death by necroptosis. Here, the authors use monobodies that bind to the MLKL pseudokinase domain as tools, which allowed them to determine the crystal ...
Sarah E. Garnish, Yanxiang Meng, Akiko Koide, Jarrod J. Sandow, Eric Denbaum, Annette V. Jacobsen, Wayland Yeung, Andre L. Samson, Christopher R. Horne, Cheree Fitzgibbon, Samuel N. Young, Phoebe P. C. Smith, Andrew I. Webb, Emma J. Petrie, Joanne M. Hildebrand, Natarajan Kannan, Peter E. Czabotar, Shohei Koide, James M. Murphy   +18 more
doaj   +2 more sources

MLKL in cancer : more than a necroptosis regulator

Cell Death & Differentiation, 2021
Mixed lineage kinase domain-like protein (MLKL) emerged as executioner of necroptosis, a RIPK3-dependent form of regulated necrosis. Cell death evasion is one of the hallmarks of cancer.
Roelandt, Ria, Takahashi, Nozomi, Vandenabeele, Peter, Martens, Sofie, Bridelance, Jolien   +4 more
core   +3 more sources

Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2019
Interferons (IFNs) are key players in the tumor immune response and act by inducing the expression of IFN-stimulated genes (ISGs). Here, we identify the mixed-lineage kinase domain-like pseudokinase (MLKL) as an ISG in various cancer cell lines.
Anne-Kathrin Knuth, Stefanie Rösler, Barbara Schenk, Lisa Kowald, Sjoerd J.L. van Wijk, Simone Fulda   +5 more
doaj   +2 more sources

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates [PDF]

Cell Reports, 2014
Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction, how MLKL transduces the death signal remains poorly understood.
Sylvie Montessuit, Sehon, Clark A., Savvas Savvides, Dondelinger, Yves, Clark A. Sehon, Marquis, Robert W., Marquis, Robert W, Montessuit, Sylvie, Weber, Kathrin, Inge Bruggeman, Roelandt, Ria, Sehon, Clark A, Amanda Goncalves, Paco Hulpiau, Bruggeman, Inge, Martinou, Jean-Claude, Wim Declercq, Bertrand, Mathieu, Peter J. Gough, Savvides, Savvas, Yves Dondelinger, Bertin, John, Declercq, Wim, Kathrin Weber, Gough, Peter J, Bertrand, Mathieu J.M., John Bertin, Gonçalves, Amanda, Jean-Claude Martinou, Ria Roelandt, Mathieu J.M. Bertrand, Robert W. Marquis, Vandenabeele, Peter, Gough, Peter J., Hulpiau, Paco, Peter Vandenabeele   +35 more
core   +6 more sources

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis [PDF]

Nature Communications, 2016
Crystals cause injury in numerous disorders, and induce inflammation via the NLRP3 inflammasome, however, it remains unclear how crystals induce cell death.
Herrmann, Martin, Krautwald, Stefan, Eberhard, Jonathan N., Anders, Hans Joachim, Thomasova, Dana, Linkermann, Andreas, Bilyy, Rostyslav, Munoz, Luis E., Grigorescu, Melissa, Zuchtriegel, Gabriele, Romoli, Simone, Romagnani, Paola, Desai, Jyaysi, Kulkarni, Onkar P., Liapis, Helen, Anders, Hans-Joachim, Mulay, Shrikant R., Kumar, Santhosh V., Popper, Bastian, Vielhauer, Volker, Reichel, Christoph, Bräsen, Jan Hinrich   +21 more
core   +7 more sources

Flicking the molecular switch underlying MLKL-mediated necroptosis [PDF]

Molecular & Cellular Oncology, 2015
The pseudokinase domain of the necroptosis effector mixed lineage kinase domain-like (MLKL) functions as a latch to restrain the unleashing of its N-terminal 4-helix bundle (4HB) domain.
Lucet, IS, Hildebrand, JM, Murphy, JM
core   +5 more sources

Spotted: RIPK3 and MLKL assembling necroptotic complexes

Open Biology
Necroptosis is a form of regulated cell death (RCD) that evolved as a defence against pathogenic infection. Unlike caspase-dependent RCD, necroptosis, in its canonical form, is driven by receptor-interacting protein kinase 1 and 3 (RIPK1 and RIPK3 ...
Martínez-Osorio, V., Ros, U. ; https://orcid.org/, García-Sáez, A. ; https://orcid.org/   +2 more
core   +4 more sources

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Tian L, Zhao M, Hu Y, Wang K, Liu H, Bai Z, Zheng K.   +6 more
europepmc   +2 more sources