Results 21 to 30 of about 881 (68)

The brain protection of MLKL inhibitor necrosulfonamide against focal ischemia/reperfusion injury associating with blocking the nucleus and nuclear envelope translocation of MLKL and RIP3K

Frontiers in Pharmacology, 2023
Mixed lineage kinase like protein (MLKL) is a key mediator of necroptosis. While previous studies highlighted the important role of MLKL as one of the central regulators of brain damage against acute ischemic neuronal injury, how the activation of MLKL ...
Xian-Yong Zhou, Bo Lin, Wei Chen, Rui-Qi Cao, Yi Guo, Ali Said, Taous Khan, Hui-Ling Zhang, Yong-Ming Zhu   +8 more
doaj   +1 more source

Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt's lymphoma cell lines

Neoplasia: An International Journal for Oncology Research, 2021
Burkitt's lymphoma (BL) is a highly aggressive form of B-cell non-Hodgkin's lymphoma. The clinical outcome in children with BL has improved over the last years but the prognosis for adults is still poor, highlighting the need for novel treatment ...
Annkathrin Koch, Birte Jeiler, Jens Roedig, Sjoerd J.L. van Wijk, Nadezda Dolgikh, Simone Fulda   +5 more
doaj   +1 more source

The critical role of MLKL in hemorrhagic stroke and the therapeutic potential of its associated protein network

Frontiers in Cell and Developmental Biology
IntroductionMixed Lineage Kinase Domain-Like Protein (MLKL), as the executor of necroptosis and a critical factor in the inflammation, has been shown to be associated with the progression of hemorrhagic stroke.
Yi Wang, Yi Wang, Moran Xu, Xiaoli Zuo, Sheng Wang, Yong Yu, Zhaobing Gao, Zhaobing Gao, Jingbo Qie, Ye Jiang, Fang Huang, Bingqing Xia, Bingqing Xia   +12 more
doaj   +1 more source

MLKL deficiency attenuated hepatocyte oxidative DNA damage by activating mitophagy to suppress macrophage cGAS-STING signaling during liver ischemia and reperfusion injury

Cell Death Discovery, 2023
Mixed-lineage kinase domain-like protein (MLKL)-mediated necroptosis has been implicated in aggravating liver ischemia and reperfusion (IR) injury. However, the precise role and mechanism of MLKL in regulating oxidative DNA damage of hepatocytes and ...
Jian Xu, Dongming Wu, Shun Zhou, Haoran Hu, Fei Li, Zhu Guan, Xinyu Zhan, Yiyun Gao, Ping Wang, Zhuqing Rao   +9 more
doaj   +1 more source

Necroptosis in bacterial infections

Frontiers in Immunology
Necroptosis, a recently discovered form of cell-programmed death that is distinct from apoptosis, has been confirmed to play a significant role in the pathogenesis of bacterial infections in various animal models. Necroptosis is advantageous to the host,
Xing Yu, Jin Yuan, Linxi Shi, Shuying Dai, Lei Yue, Min Yan   +5 more
doaj   +1 more source

Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells

Communications Biology, 2023
Non-small cell lung cancer (NSCLC) is the most prevalent type of cancer and the leading cause of cancer-related death. Chemotherapeutic resistance is a major obstacle in treating NSCLC patients.
Huiling Zhou, Li Zhou, Qing Guan, Xuyang Hou, Cong Wang, Lijun Liu, Jian Wang, Xinfang Yu, Wei Li, Haidan Liu   +9 more
doaj   +1 more source

The pseudokinase MLKL contributes to host defense against Streptococcus pluranimalium infection by mediating NLRP3 inflammasome activation and extracellular trap formation

Virulence, 2023
Host innate immunity plays a pivotal role in the early detection and neutralization of invading pathogens. Here, we show that pseudokinase mixed lineage kinase-like protein (MLKL) is required for host defence against Streptococcus pluranimalium infection
Yu-Xin Lei, Yang Liu, Li-Hua Xing, Yu-Jing Wu, Xue-Yin Wang, Fan-Hua Meng, Ya-Nan Lou, Zhao-Guo Ma, Lin Yuan, Shui-Xing Yu   +9 more
doaj   +1 more source

Nuclear translocation of MLKL enhances necroptosis by a RIP1/RIP3-independent mechanism in H9c2 cardiomyoblasts

Journal of Pharmacological Sciences, 2023
Accumulating evidence suggests that necroptosis of cardiomyocytes contributes to cardiovascular diseases. Lethal disruption of the plasma membrane in necroptosis is induced by oligomers of mixed lineage kinase domain-like (MLKL) that is translocated to ...
Shoya Ino, Toshiyuki Yano, Atsushi Kuno, Masaya Tanno, Hidemichi Kouzu, Tatsuya Sato, Tomohisa Yamashita, Wataru Ohwada, Arata Osanami, Toshifumi Ogawa, Yuki Toda, Masaki Shimizu, Tetsuji Miura   +12 more
doaj   +1 more source

Mechanistic analysis of MLKL-driven cell survival

Cell Death Discovery
MLKL pseudokinase is a critical executioner of necroptotic cell death. MLKL drives necroptosis by forming pores in the cell membrane. A growing body of data indicates that, in addition to this well-established role, MLKL can promote cell survival in ...
Peijia Jiang, Xiaoyang Liu, Mauricio J. Reginato, Kirill V. Rosen   +3 more
doaj   +1 more source

TREM-1 deficiency attenuates RIPK3/MLKL-associated epithelial injury in Klebsiella pneumoniae-induced acute lung injury

Frontiers in Cell and Developmental Biology
BackgroundKlebsiella pneumoniae (KP)-induced acute lung injury involves excessive myeloid inflammation, epithelial barrier disruption, and inflammatory cell death.
Wei Zhang, Song Meng, Jiali Huang, Enfang Xiao, Yang Bai, Li Zhao, Kaifei Wang   +6 more
doaj   +1 more source