Results 21 to 30 of about 12,009 (206)

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis [PDF]

Nature Communications, 2016
AbstractCrystals cause injury in numerous disorders, and induce inflammation via the NLRP3 inflammasome, however, it remains unclear how crystals induce cell death. Here we report that crystals of calcium oxalate, monosodium urate, calcium pyrophosphate dihydrate and cystine trigger caspase-independent cell death in five different cell types, which is ...
Mulay, Shrikant R., Desai, Jyaysi, Kumar, Santhosh V., Eberhard, Jonathan N., Thomasova, Dana, ROMOLI, SIMONE, Grigorescu, Melissa, Kulkarni, Onkar P., Popper, Bastian, Vielhauer, Volker, Zuchtriegel, Gabriele, Reichel, Christoph, Bräsen, Jan Hinrich, ROMAGNANI, PAOLA, Bilyy, Rostyslav, Munoz, Luis E., Herrmann, Martin, Liapis, Helen, Krautwald, Stefan, Linkermann, Andreas, ANDERS, HANS JOACHIM   +20 more
openaire   +8 more sources

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis [PDF]

Nature Communications, 2020
Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. Here the authors show that MLKL trafficking and plasma membrane accumulation are crucial necroptosis checkpoints, and that ...
Andre L. Samson, Ying Zhang, Niall D. Geoghegan, Xavier J. Gavin, Katherine A. Davies, Michael J. Mlodzianoski, Lachlan W. Whitehead, Daniel Frank, Sarah E. Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N. Young, Annette V. Jacobsen, Wayne Cawthorne, Emma J. Petrie, Maree C. Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M. Hildebrand, John Silke, Kelly L. Rogers, Guillaume Lessene, Edwin D. Hawkins, James M. Murphy   +23 more
doaj   +2 more sources

The molecular mechanisms of MLKL-dependent and MLKL-independent necrosis [PDF]

Journal of Molecular Cell Biology, 2020
AbstractNecrosis, a type of unwanted and passive cell demise, usually occurs under the excessive external stress and is considered to be unregulated. However, under some special conditions such as caspase inhibition, necrosis is regulable in a well-orchestrated way.
Li, Lu, Tong, An, Zhang, Qiangsheng, Wei, Yuquan, Wei, Xiawei   +4 more
openaire   +2 more sources

MLKL-like N-termini. [PDF]

, 2022
a) Fingerprint alignment of the doubly (Goodbye-like & Helo-like) annotated OBZ65626 cluster including non-redundant sequences with direct Pfam annotations. The alignment was truncated C-terminally.
Marlena Gąsior-Głogowska (10726270), Virginie Coustou (252355), Witold Dyrka (14290529), Sven J. Saupe (14290526), Monika Szefczyk (10726273), Jakub W. Wojciechowski (14290517), Emirhan Tekoglu (14290520), Natalia Szulc (10726276), Marta Kopaczyńska (14290523)   +8 more
core   +1 more source

MLKL D144K mutation activates the necroptotic activity of the N-terminal MLKL domain [PDF]

, 2021
Abstract Mixed-lineage kinase domain-like protein (MLKL) is an essential effector protein of necroptotic cell death. The four-helix bundle domain (4HB) presented by the first 125 amino acids of the N-terminal domain is sufficient for its necroptotic activity. However, it has been proposed that the subsequent helix H6 of the brace region
Katja Hrovat-Schaale, Maruša Kalič-Prolinšek, San Hadži, Jurij Lah, Gregor Gunčar   +4 more
openaire   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Angiotensin II triggers RIPK3-MLKL-mediated necroptosis by activating the Fas/FasL signaling pathway in renal tubular cells - Fig 3 [PDF]

, 2020
Nec-1 suppresses RIP and p-RIP, RIP3 and p-RIP3, MLKL and p-MLKL protein expression in the kidney tissues from AngII-treated mice (A) Representative blots of RIP and p-RIP, RIP3 and p-RIP3, MLKL and p-MLKL protein in the Ang II-induced chronic renal ...
Hongwang Cui (2826101), Yongjun Zhu (2794957), Liangbao Zhong (8538618), Xiaoyan Li (117291), Feng Ye (173489), Jie Lv (235936), Guojun Li (16705)   +6 more
core   +1 more source

Necroptosis in Pulmonary Diseases: A New Therapeutic Target

Frontiers in Pharmacology, 2021
In the past decades, apoptosis has been the most well-studied regulated cell death (RCD) that has essential functions in tissue homeostasis throughout life.
Lingling Wang, Ling Zhou, Yuhao Zhou, Lu Liu, Weiling Jiang, Huojun Zhang, Huiguo Liu   +6 more
doaj   +1 more source

RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-α. [PDF]

, 2020
Cytokine-primed neutrophils can undergo a nonapoptotic type of cell death using components of the necroptotic pathway, including receptor-interacting protein kinase-3 (RIPK3), mixed lineage kinase-like (MLKL) and NADPH oxidase. In this report, we provide
Perozzo, Remo, Hosseini, Aref, Simon, Hans-Uwe, Kuchen, Stefan, Gessier, Francois, Amirshahrokhi, Keyvan, Loetscher, Pius, Yousefi, Shida, Lötscher, Pius, Stojkov, Darko, Wang, Xiaoliang   +10 more
core   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source