Results 21 to 30 of about 13,017 (220)

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis [PDF]

Nature Communications, 2020
Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. Here the authors show that MLKL trafficking and plasma membrane accumulation are crucial necroptosis checkpoints, and that ...
Andre L. Samson, Ying Zhang, Niall D. Geoghegan, Xavier J. Gavin, Katherine A. Davies, Michael J. Mlodzianoski, Lachlan W. Whitehead, Daniel Frank, Sarah E. Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N. Young, Annette V. Jacobsen, Wayne Cawthorne, Emma J. Petrie, Maree C. Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M. Hildebrand, John Silke, Kelly L. Rogers, Guillaume Lessene, Edwin D. Hawkins, James M. Murphy   +23 more
doaj   +2 more sources

The molecular mechanisms of MLKL-dependent and MLKL-independent necrosis [PDF]

Journal of Molecular Cell Biology, 2020
AbstractNecrosis, a type of unwanted and passive cell demise, usually occurs under the excessive external stress and is considered to be unregulated. However, under some special conditions such as caspase inhibition, necrosis is regulable in a well-orchestrated way.
Li, Lu, Tong, An, Zhang, Qiangsheng, Wei, Yuquan, Wei, Xiawei   +4 more
openaire   +2 more sources

Investigating MLKL Regulation in Necroptosis

Necroptosis is a form of regulated necrosis mediated by the mixed lineage kinase domain-like (MLKL), which naturally exists in alternative spliced isoforms.
Sabuncuoğlu, B.
core   +2 more sources

MLKL D144K mutation activates the necroptotic activity of the N-terminal MLKL domain [PDF]

, 2021
Abstract Mixed-lineage kinase domain-like protein (MLKL) is an essential effector protein of necroptotic cell death. The four-helix bundle domain (4HB) presented by the first 125 amino acids of the N-terminal domain is sufficient for its necroptotic activity. However, it has been proposed that the subsequent helix H6 of the brace region
Katja Hrovat-Schaale, Maruša Kalič-Prolinšek, San Hadži, Jurij Lah, Gregor Gunčar   +4 more
openaire   +1 more source

Melatonin Protects BEAS-2B Cells Against Hypoxia/Reoxygenation-Induced Injury By Reducing MLKL Levels, Suppressing Oxidative Stress and Preserving Mitochondrial Function. [PDF]

Cell Biochem Funct
ABSTRACT Necroptosis has been demonstrated to play a role in the process of lung ischemia‐reperfusion injury (LIRI) in a variety of clinical conditions, including cardiopulmonary bypass and pulmonary embolism. Melatonin has been reported to exert a protective role by reducing oxidative stress and acute inflammatory reactions in LIRI.
Yilmaz Z, Tas A, Oz O, Koyuncu I, Temiz E, Yuksekdag O.   +5 more
europepmc   +2 more sources

RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-α. [PDF]

, 2020
Cytokine-primed neutrophils can undergo a nonapoptotic type of cell death using components of the necroptotic pathway, including receptor-interacting protein kinase-3 (RIPK3), mixed lineage kinase-like (MLKL) and NADPH oxidase. In this report, we provide
Perozzo, Remo, Hosseini, Aref, Simon, Hans-Uwe, Kuchen, Stefan, Gessier, Francois, Amirshahrokhi, Keyvan, Loetscher, Pius, Yousefi, Shida, Lötscher, Pius, Stojkov, Darko, Wang, Xiaoliang   +10 more
core   +1 more source

β-Caryophyllene Mitigates Thioacetamide-Induced Liver Fibrosis Through CB2-Mediated Suppression of Necroptosis: A Therapeutic Investigation. [PDF]

Pharmacol Res Perspect
β‐Caryophyllene is a multifunctional sesquiterpene with significant therapeutic potential. Our findings demonstrate that β‐caryophyllene exerts broad hepatoprotective effects through the activation of cannabinoid type 2 (CB2) receptors. These effects include suppression of oxidative stress–induced injury, attenuation of inflammatory responses ...
Eddin LB, Arunachalam S, Lubbad L, Hammad FT, Adeghate E, Subramanya S, Ojha S.   +6 more
europepmc   +2 more sources

Evolutionary divergence of the necroptosis effector MLKL [PDF]

Cell Death & Differentiation, 2016
The pseudokinase, MLKL (mixed-lineage kinase domain-like), is the most terminal obligatory component of the necroptosis cell death pathway known. Phosphorylation of the MLKL pseudokinase domain by the protein kinase, receptor interacting protein kinase-3 (RIPK3), is known to be the key step in MLKL activation.
M C, Tanzer, I, Matti, J M, Hildebrand, S N, Young, A, Wardak, A, Tripaydonis, E J, Petrie, A L, Mildenhall, D L, Vaux, J E, Vince, P E, Czabotar, J, Silke, J M, Murphy   +12 more
openaire   +2 more sources

MLKL-like N-termini.

, 2022
a) Fingerprint alignment of the doubly (Goodbye-like & Helo-like) annotated OBZ65626 cluster including non-redundant sequences with direct Pfam annotations. The alignment was truncated C-terminally.
Marlena Gąsior-Głogowska (10726270), Virginie Coustou (252355), Witold Dyrka (14290529), Sven J. Saupe (14290526), Monika Szefczyk (10726273), Jakub W. Wojciechowski (14290517), Emirhan Tekoglu (14290520), Natalia Szulc (10726276), Marta Kopaczyńska (14290523)   +8 more
core   +1 more source

Acylation of MLKL impacts its function in necroptosis

ACS Chemical Biology, 2023
ABSTRACT Mixed lineage kinase domain-like (MLKL) is a key signaling protein of necroptosis. Upon activation by phosphorylation, MLKL translocates to the plasma membrane and induces membrane permeabilization which contributes to the necroptosis-associated inflammation. Membrane binding of MLKL is initially initiated by
Apoorva J. Pradhan, Shweta Chitkara, Ricardo X. Ramirez, Viviana Monje-Galvan, Yasemin Sancak, G. Ekin Atilla-Gokcumen   +5 more
openaire   +3 more sources