Results 81 to 90 of about 52,832 (305)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

The Function of Necroptosis and Its Treatment Target in IBD

Mediators of Inflammation
Inflammatory bowel disease (IBD), which encompasses Crohn’s disease (CD) and ulcerative colitis (UC), is a complicated illness whose exact cause is yet unknown.
Francis Atim Akanyibah, Yi Zhu, Tao Jin, Dickson Kofi Wiredu Ocansey, Fei Mao, Wei Qiu   +5 more
doaj   +1 more source

Mechanisms of Action and Cell Death Associated with Clostridium perfringens Toxins. [PDF]

, 2018
Clostridium perfringens uses its large arsenal of protein toxins to produce histotoxic, neurologic and intestinal infections in humans and animals. The major toxins involved in diseases are alpha (CPA), beta (CPB), epsilon (ETX), iota (ITX), enterotoxin (
McClane, Bruce A, Navarro, Mauricio A, Uzal, Francisco A   +2 more
core   +3 more sources

Necroptosis in stressed ovary

Journal of Biomedical Science, 2019
Stress is deeply rooted in the modern society due to limited resources and large competition to achieve the desired goal. Women are more frequently exposed to several stressors during their reproductive age that trigger generation of reactive oxygen species (ROS).
Govind R. Chaudhary, Pramod K. Yadav, Anil K. Yadav, Meenakshi Tiwari, Anumegha Gupta, Alka Sharma, Ashutosh N. Pandey, Ajai K. Pandey, Shail K. Chaube   +8 more
openaire   +3 more sources

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Necroptosis in Macrophage Foam Cells Promotes Fat Graft Fibrosis in Mice

Frontiers in Cell and Developmental Biology, 2021
Background: Fibrosis is a major grafting-related complication that leads to fat tissue dysfunction. Macrophage-induced inflammation is related to the development of fat tissue fibrosis.
Xihang Chen, Zilong Deng, Jingwei Feng, Qiang Chang, Feng Lu, Yi Yuan   +5 more
doaj   +1 more source

Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. [PDF]

, 2019
PGAM5 is a mitochondrial protein phosphatase whose genetic ablation in mice results in mitochondria-related disorders, including neurodegeneration. Functions of PGAM5 include regulation of mitophagy, cell death, metabolism and aging.
Agnew, Christopher, Frost, Adam, Herrera, Clara, Ingaramo, Maria, Jura, Natalia, Miller-Vedam, Lakshmi, Ruiz, Karen, Thaker, Tarjani M, Toso, Daniel, Trenker, Raphael   +9 more
core   +3 more sources

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Measurement and models accounting for cell death capture hidden variation in compound response. [PDF]

, 2020
Cancer cell sensitivity or resistance is almost universally quantified through a direct or surrogate measure of cell number. However, compound responses can occur through many distinct phenotypic outcomes, including changes in cell growth, apoptosis, and
Bae, Song Yi, Guan, Ning, Meyer, Aaron S, Taylor, Scott D, Warner, Katrina, Yan, Rui   +5 more
core   +1 more source

Necroptosis in health and diseases

Seminars in Cell & Developmental Biology, 2014
Necroptosis is a form of regulated necrosis that can be activated by ligands of death receptors and stimuli that induce the expression of death receptor ligands under apoptotic deficient conditions. Activation of necroptosis by ligands of death receptors requires the kinase activity of RIP1, which mediates the activation of RIP3 and MLKL, two critical ...
Zhou, Wen, Yuan, Junying
openaire   +2 more sources