Results 81 to 90 of about 47,289 (162)

Clinical Implications of Necroptosis Biomarkers in Sepsis [PDF]

open access: yes
Necroptosis is a cell death process that is attractively unique and separate from apoptosis, as indicated by the involvement of receptor-interacting protein kinases (RIPK) and mixed lineage kinase domain pseudokinase (MLKL).
Haloho, Agustina Br.   +3 more
core   +1 more source

Intracellular redox changes during TNFα-mediated necroptosis

open access: yes, 2018
Necroptosis is a form of regulated cell death triggered by a variety of factors associated with infection and inflammation. It is distinct from the well-characterised cell death processes of apoptosis and necrosis, sharing the morphology of necrosis but ...
Heath, Sarah
core   +1 more source

Necroptosis Mediates Cigarette Smoke-Induced Inflammatory Responses in Macrophages

open access: yesInternational Journal of COPD, 2020
Yong Wang, Xiao-Ke Wang, Pei-Pei Wu, Yi Wang, Liang-Yu Ren, Ai-Hui Xu Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Anhui Medical University, Hefei 230022, People’s Republic of ChinaCorrespondence: Ai-Hui ...
Wang Y   +5 more
doaj  

Investigating MLKL Regulation in Necroptosis

open access: yes
Necroptosis is a form of regulated necrosis mediated by the mixed lineage kinase domain-like (MLKL), which naturally exists in alternative spliced isoforms.
Sabuncuoğlu, B.
core  

AQP1 Affects Necroptosis by Targeting RIPK1 in Endothelial Cells of Atherosclerosis [PDF]

open access: yes
Ping Wang,1,* Lin Zheng,1,* Yusi Yang,2,* Xinyang Yue,1 Jie Liu,3 Keyi Fan,1 Haonan Zhou,4 Honglin Dong1 1Department of Vascular Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2Department of ...
Liu J   +7 more
core  

Necroptosis and its role in inflammation

open access: yes, 2015
Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis is a newly discovered pathway of regulated necrosis that requires the proteins RIPK3 and MLKL and is induced by death receptors, interferons, toll ...
Pasparakis, Manolis   +3 more
core   +1 more source

Identification of KW-2449 as a dual inhibitor of ferroptosis and necroptosis reveals that autophagy is a targetable pathway for necroptosis inhibitors to prevent ferroptosis

open access: yesCell Death and Disease
Necroptosis and ferroptosis are two distinct forms of necrotic-like cell death in terms of their morphological features and regulatory mechanisms. These two types of cell death can coexist in disease and contribute to pathological processes.
Yaxing Zhao   +15 more
doaj   +1 more source

Novel Diagnostic Biomarkers Related to Necroptosis and Immune Infiltration in Coronary Heart Disease [PDF]

open access: yes
Qiu Chen,1 Ji-Lei Zhang,1 Jie-Shun Yang,2 Qing Jin,1 Jun Yang,3 Qiang Xue,1 Xue-feng Guang1 1Department of Cardiology, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, People’s Republic of China; 2Department of Pathology, The Second ...
Chen Q   +6 more
core  

Necroptosis: a new link between cell death and inflammation

open access: yes, 2016
Necroptosis is a type of newly identified cell death induced by apoptotic stimuli under conditions where apoptotic execution is prevented. Studies over the past 10 years have revealed the molecular mechanism of necroptosis and challenged the old ...
Zhang, Xiu-Fen   +8 more
core  

Small Molecule Conjugation of Hsp70 Inhibits Necroptosis

open access: yes, 2020
Necroptosis is a subtype of regulated necrosis in which signaling through receptor interacting protein kinase 3 (RIPK3) triggers caspase independent, immunogenic cell death morphologically identical to necrosis. Necroptosis is physiologically relevant in
Johnston, Andrea N.
core  

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