Results 81 to 90 of about 43,311 (200)
Necroptosis as a mechanism of cellular death and its clinical significance
, 2019 Necroptosis is a newly discovered cell death. It relies on the interaction of the three key molecules RIPK1, RIPK3 and MLKL, when caspase-8 is inhibited.
Tslaf, Vera
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Necroptosis takes place in human immunodeficiency virus type-1 (HIV-1)-infected CD4+ T lymphocytes.
PLoS ONE, 2014 Human immunodeficiency virus type 1 (HIV-1) infection is characterized by progressive depletion of CD4+ T lymphocytes and dysfunction of the immune system.
Ting Pan +11 more
doaj +1 more source
Opposing regulation of the K63-linked polyubiquitination of RIPK3 by SMURF1 and USP5 in necroptosis
Nature CommunicationsReceptor-interacting protein kinase 3 (RIPK3), a key regulator of necroptosis, is modulated by ubiquitination through various E3 ligases and deubiquitinases.
Chi Hyun Hwang +9 more
doaj +1 more source
Targeting hepatocyte necroptosis to treat liver diseases
, 2017 Tese de doutoramento, Farmácia (Biologia Celular e Molecular), Universidade de Lisboa, Faculdade de Farmácia, 2017Chronic liver diseases are considered a major public health concern, and their prevalence and incidence are increasing with serious long ...
Afonso, Marta
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Autophagy, selective autophagy, and necroptosis in COPD
, 2018 Kenji Mizumura, Shuichiro Maruoka, Tetsuo Shimizu, Yasuhiro Gon Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan Abstract: COPD is characterized by persistent respiratory symptoms and ...
Maruoka S, Gon Y, Shimizu T, Mizumura K
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Cell Death and Disease, 2020 Intestinal ischemia reperfusion (I/R) injury is the important pathogenesis for acute intestinal barrier disruption. The STING signaling is associated with gut homeostasis and barrier integrity.
Xufei Zhang +9 more
doaj +1 more source
Ppm1b negatively regulates necroptosis through dephosphorylating Rip3 [PDF]
, 2015 该研究论文发现蛋白磷酸酶Ppm1b 通过去磷酸化RIP3负调控程序性细胞坏死（necroptosis），阐明了RIP3磷酸化状态的精确调控对于细胞和机体在生理和病理状态下的存活至关重要。The auto-phosphorylation of murine receptor-interacting protein 3 (Rip3) on Thr 231 and Ser 232 in the necrosome is required to trigger necroptosis.
陈万泽 +19 more
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Novel Diagnostic Biomarkers Related to Necroptosis and Immune Infiltration in Coronary Heart Disease [PDF]
Qiu Chen,1 Ji-Lei Zhang,1 Jie-Shun Yang,2 Qing Jin,1 Jun Yang,3 Qiang Xue,1 Xue-feng Guang1 1Department of Cardiology, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, People’s Republic of China; 2Department of Pathology, The Second ...
Chen Q +6 more
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AQP1 Affects Necroptosis by Targeting RIPK1 in Endothelial Cells of Atherosclerosis [PDF]
Ping Wang,1,* Lin Zheng,1,* Yusi Yang,2,* Xinyang Yue,1 Jie Liu,3 Keyi Fan,1 Haonan Zhou,4 Honglin Dong1 1Department of Vascular Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2Department of ...
Liu J +7 more
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, 2020 Necroptosis is a regulated necrotic cell death pathway involved in development and disease. Its signaling cascade results in the formation of disulfide bond-dependent amyloid-like polymers of mixed lineage kinase domain-like protein (MLKL), which mediate
Johnston, Andrea
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