Results 101 to 110 of about 43,311 (200)

LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL

Cell Death and Disease
Plasma membrane accumulation of phosphorylated mixed lineage kinase domain-like (MLKL) is a hallmark of necroptosis, leading to membrane rupture and inflammatory cell death.
Nadine Weinelt, Kaja Nicole Wächtershäuser, Gulustan Celik, Birte Jeiler, Isabelle Gollin, Laura Zein, Sonja Smith, Geoffroy Andrieux, Tonmoy Das, Jens Roedig, Leonard Feist, Björn Rotter, Melanie Boerries, Francesco Pampaloni, Sjoerd J. L. van Wijk   +14 more
doaj   +1 more source

A novel necroptosis-related gene signature predicts the prognosis and immunotherapeutic response in breast cancer through immune infiltration

Discover Oncology
Growing evidence has demonstrated the association between necroptosis and tumorigenesis and immunotherapy. However, the influence of overall necroptosis related genes on prognosis and immune microenvironment of breast cancer is still unclear.
Dezhi Lu, Sifang Qiu, Zhiqiang Zeng
doaj   +1 more source

Cyclooxygenase-2/Prostaglandin E2 Pathway Facilitates Infectious Bronchitis Virus-Induced Necroptosis in Chicken Macrophages, a Caspase-Independent Cell Death

Viruses
Infectious bronchitis virus (IBV) poses a major challenge to poultry health and productivity. This study examined how inflammatory cell death pathways influence the replication and pathogenesis of two IBV strains—respiratory Connecticut (Conn) A5968 and ...
Motamed Elsayed Mahmoud, Dylan Tingley, Akeel Faizal, Awais Ghaffar, Muhammed Azhar, Doaa Salman, Ishara M. Isham, Mohamed Faizal Abdul-Careem   +7 more
doaj   +1 more source

Necroptosis Mediates Cigarette Smoke-Induced Inflammatory Responses in Macrophages

International Journal of COPD, 2020
Yong Wang, Xiao-Ke Wang, Pei-Pei Wu, Yi Wang, Liang-Yu Ren, Ai-Hui Xu Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Anhui Medical University, Hefei 230022, People’s Republic of ChinaCorrespondence: Ai-Hui ...
Wang Y, Wang XK, Wu PP, Wang Y, Ren LY, Xu AH   +5 more
doaj  

The potential role of necroptosis in diseases

, 2014
Although the morphological appearance of necrosis has been described by pathologists already in the early nineteenth century long before the discovery of programmed cell death (PCD) or apoptosis, we only start to understand some of the molecular ...
Vanden Berghe, Tom, Andreas Linkermann, Krautwald, Stefan, Kunzendorf, Ulrich, Stefan Krautwald, Linkermann, Andreas, Takahashi, Nozomi, Vandenabeele, Peter, Tom Vanden Berghe, Nozomi Takahashi, Ulrich Kunzendorf, Peter Vandenabeele   +11 more
core   +1 more source

Intracellular redox changes during TNFα-mediated necroptosis

, 2018
Necroptosis is a form of regulated cell death triggered by a variety of factors associated with infection and inflammation. It is distinct from the well-characterised cell death processes of apoptosis and necrosis, sharing the morphology of necrosis but ...
Heath, Sarah
core   +1 more source

Necroptosis and its role in inflammation

, 2015
Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis is a newly discovered pathway of regulated necrosis that requires the proteins RIPK3 and MLKL and is induced by death receptors, interferons, toll ...
Pasparakis, Manolis, Vandenabeele, Peter, Manolis Pasparakis, Peter Vandenabeele   +3 more
core   +1 more source

Identification of KW-2449 as a dual inhibitor of ferroptosis and necroptosis reveals that autophagy is a targetable pathway for necroptosis inhibitors to prevent ferroptosis

Cell Death and Disease
Necroptosis and ferroptosis are two distinct forms of necrotic-like cell death in terms of their morphological features and regulatory mechanisms. These two types of cell death can coexist in disease and contribute to pathological processes.
Yaxing Zhao, Qingsong Wang, Jing Zhu, Jin Cai, Xiaona Feng, Qianqian Song, Hui Jiang, Wenqing Ren, Yuan He, Ping Wang, Du Feng, Jianqiang Yu, Yue Liu, Qihui Wu, Siriporn Jitkaew, Zhenyu Cai   +15 more
doaj   +1 more source

Investigating MLKL Regulation in Necroptosis

Necroptosis is a form of regulated necrosis mediated by the mixed lineage kinase domain-like (MLKL), which naturally exists in alternative spliced isoforms.
Sabuncuoğlu, B.
core  

Identification and Validation of a Necroptosis-Related Prognostic Model in Tumor Recurrence and Tumor Immune Microenvironment in Breast Cancer Management [PDF]

Xiaobo Wang,1 Zongyao Chen,1 Jianing Tang,2,3 Jing Cao2,4– 6 1Department of General Surgery, the Second Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China; 2National Clinical Research Center for Geriatric Disorders,
Tang J, Chen Z, Cao J, Wang X
core