Results 91 to 100 of about 43,311 (200)

BRAF and AXL oncogenes drive RIPK3 expression loss in cancer.

PLoS Biology, 2018
Necroptosis is a lytic programmed cell death mediated by the RIPK1-RIPK3-MLKL pathway. The loss of Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) expression and necroptotic potential have been previously reported in several cancer cell ...
Ayaz Najafov, Ioannis K Zervantonakis, Adnan K Mookhtiar, Patricia Greninger, Ryan J March, Regina K Egan, Hoang Son Luu, Daniel G Stover, Ursula A Matulonis, Cyril H Benes, Junying Yuan   +10 more
doaj   +1 more source

Activation of Necroptosis in Multiple Sclerosis

Cell Reports, 2015
Multiple sclerosis (MS), a common neurodegenerative disease of the CNS, is characterized by the loss of oligodendrocytes and demyelination. Tumor necrosis factor α (TNF-α), a proinflammatory cytokine implicated in MS, can activate necroptosis, a necrotic cell death pathway regulated by RIPK1 and RIPK3 under caspase-8-deficient conditions.
Ofengeim, Dimitry, Ito, Yasushi, Najafov, Ayaz, Zhang, Yaoyang, Shan, Bing, Dewitt, Judy Park, Ye, Juanying, Zhang, Xumin, Chang, Ansi, Vakifahmetoglu-Norberg, Helin, Geng, Jiefei, Py, Benedicte, Zhou, Wen, Amin, Palak, Lima, Jonilson Berlink, Qi, Chunting, Yu, Qiang, Trapp, Bruce, Yuan, Junying   +18 more
openaire   +5 more sources

Endoplasmic reticulum stress-induced necroptosis promotes cochlear inflammation: Implications for age-related hearing loss

Experimental Gerontology
Age-related hearing loss (ARHL) is the most common sensory disorder associated with human aging. Chronic inflammation is supposed to be an important contributor to ARHL.
Zhongwu Su, Yi Liu, Weijian Zhang, Wenhui Liang, Yuyan Chen, Jinyuan Cao, Yu Liu, Yiqing Zheng, Qi Li   +8 more
doaj   +1 more source

MicroRNAs in apoptosis, autophagy and necroptosis

Oncotarget, 2015
MicroRNAs (miRNAs) are endogenous 22 nt non-coding RNAs that target mRNAs for cleavage or translational repression. Numerous miRNAs regulate programmed cell death including apoptosis, autophagy and necroptosis. We summarize how miRNAs regulate apoptotic, autophagic and necroptotic pathways and cancer progression.
Su, Zhenyi, Yang, Zuozhang, Xu, Yongqing, Chen, Yongbin, Yu, Qiang   +4 more
openaire   +4 more sources

Construction of a Novel Necroptosis-Related Signature in Rat DRG for Neuropathic Pain [PDF]

Yang Liu,1 Shikang Hao,2 Hongyu Hao,3 Guona Zheng,1 Jie Bing,1 Lin Kang,1 Jia Li,4 Huanfen Zhao,1,* Han Hao5,* 1Department of Pathology, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 2The First Clinical Medical School, Shanxi ...
Liu Y, Bing J, Li J, Hao H, Zheng G, Hao S, Kang L, Zhao H   +7 more
core  

HSP70 promotes MLKL polymerization and necroptosis

, 2020
Mixed lineage kinase domain-like protein (MLKL) is the proposed executioner of necroptosis. Our recent findings identify a novel inhibitor necroptosis-blocking compound 1 (NBC1) which specifically conjugates to two cysteines of heat shock protein 70 ...
Zhigao Wang, Andrea N. Johnston
core   +1 more source

Using drugs to target necroptosis: dual roles in disease therapy [PDF]

, 2018
Necroptosis is programmed necrosis, a process which has been studied for over a decade. The most common accepted mechanism is through the RIP1- RIP3-MLKL axis to regulate necroptotic cell death.
Wang, Shu Chao, Zhou, Hong kang, Chen, Dan, Xiong, Kun, Wang, Zhen, Guo, Li Min, Liu, Feng Xia, Huang, Ju Fang, Qu, Hong ke   +8 more
core   +1 more source

Necroptosis in bacterial infections

Frontiers in Immunology
Necroptosis, a recently discovered form of cell-programmed death that is distinct from apoptosis, has been confirmed to play a significant role in the pathogenesis of bacterial infections in various animal models. Necroptosis is advantageous to the host, but in some cases, it can be detrimental.
Xing Yu, Jin Yuan, Linxi Shi, Shuying Dai, Lei Yue, Min Yan   +5 more
openaire   +3 more sources

Necroptosis sensitivity screen in 941 cancer cell lines identifies drivers of necroptosis resistance.

, 2018
(A) Outline of the high-throughput screening for differential necroptosis sensitivity in 941 human cancer cell lines. (B) Differential sensitivity of 941 cancer cell lines to TSZ-induced necroptosis across 28 tissues of origin.
Adnan K. Mookhtiar (5698016), Ursula A. Matulonis (183863), Cyril H. Benes (408440), Ioannis K. Zervantonakis (116012), Ryan J. March (5698019), Hoang Son Luu (5698022), Junying Yuan (728818), Ayaz Najafov (322631), Regina K. Egan (5540828), Patricia Greninger (5540831), Daniel G. Stover (5698025)   +10 more
core   +1 more source

Regulation of Necroptosis by Phospholipids and Sphingolipids

, 2020
Several non-apoptotic regulated cell death pathways have been recently reported. Necroptosis, a form of necrotic-regulated cell death, is characterized by the involvement of receptor-interacting protein kinases and/or the pore-forming mixed lineage ...
Masaya Matsuda, Takeshi Nabe, Nobuo Yaegashi, Kazuyuki Kitatani, Xuewei Zhang   +4 more
core   +1 more source