Results 31 to 40 of about 43,311 (200)

Targeting necroptosis in fibrosis

Molecular Biology Reports, 2023
AbstractNecroptosis, a type of programmed cell death that resembles necrosis, is now known to depend on a different molecular mechanism from apoptosis, according to several recent studies. Many efforts have reported the possible influence of necroptosis in human disorders and concluded the crucial role in the pathophysiology of various diseases ...
Hassanein, Emad H. M., Ibrahim, Islam M., Abd El-Maksoud, Mostafa S., Abd El-Aziz, Mostafa K., Abd-alhameed, Esraa K., Althagafy, Hanan S.   +5 more
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A Glimpse of necroptosis and diseases

Biomedicine & Pharmacotherapy, 2022
Programmed cell death plays an important role in maintaining homeostasis. Necroptosis is a type of programmed cell death that has been recently discovered. It is mediated by RIPK1, RIPK3, and MLKL, and is characterized by necrotic cell morphology. Interestingly, the abnormal activation of necroptosis could lead to inflammation and a variety of diseases.
Ming, Yang, Wei, Chen, Liyu, He, Di, Liu, Li, Zhao, Xi, Wang   +5 more
openaire   +2 more sources

Intestinal epithelial cells necroptosis and its association with intestinal inflammation [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2019
This review focuses on the role of necroptosis, an alternative mode of cell death, in the pathogenesis of diseases associated with intestinal inflammation whose prevalence has been significantly increased for last decades, which substantiates the ...
Anton S. Tkachenko
doaj   +1 more source

HNEAP Regulates Necroptosis of Cardiomyocytes by Suppressing the m5C Methylation of Atf7 mRNA

Advanced Science, 2023
PIWI‐interacting RNAs (piRNAs) are highly expressed in various cardiovascular diseases. However, their role in cardiomyocyte death caused by ischemia/reperfusion (I/R) injury, especially necroptosis, remains elusive.
Kai Wang, Fu‐Hai Li, Lu‐Yu Zhou, Xue‐Mei Zhao, Xiang‐Qian Gao, Cui‐Yun Liu, Xin‐Min Li, Xin‐Zhe Chen, Yan Zhao, Xue‐Li Cheng, Rui‐Quan Wang, Rui‐Feng Li, Yu‐Hui Zhang, Fei Gao, Jin‐Wei Tian, Kun Wang   +15 more
doaj   +1 more source

CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN

Cell Reports, 2016
Tumor necrosis factor (TNF) induces necroptosis, a RIPK3/MLKL-dependent form of inflammatory cell death. In response to infection by Gram-negative bacteria, multiple receptors on macrophages, including TLR4, TNF, and type I IFN receptors, are ...
Diana Legarda, Scott J. Justus, Rosalind L. Ang, Nimisha Rikhi, Wenjing Li, Thomas M. Moran, Jianke Zhang, Emiko Mizoguchi, Matija Zelic, Michelle A. Kelliher, J. Magarian Blander, Adrian T. Ting   +11 more
doaj   +1 more source

M2-like macrophages exert hepatoprotection in acute-on-chronic liver failure through inhibiting necroptosis-S100A9-necroinflammation axis

Cell Death and Disease, 2021
Necroptosis has emerged as a novel and crucial player in acute and chronic liver diseases. Necroptotic cells lead to the release of DAMPs including S100A9, followed by the development of necroinflammation.
Li Bai, Ming Kong, Zhongping Duan, Shuang Liu, Sujun Zheng, Yu Chen   +5 more
doaj   +1 more source

Bibliometric analysis of publications on necroptosis from 2001 to 2021

Frontiers in Cell and Developmental Biology, 2022
Background: Necroptosis plays an important role in inflammation, cancer, and neurodegenerative diseases. In recent years, the number of studies related to necroptosis has increased and research has become increasingly in-depth.
Yang Liu, Yang Liu, Xiaojiang Zhou, Xiaojiang Zhou, Fangfei Wang, Fangfei Wang, Cong Liu, Cong Liu, Jun Xie, Jun Xie, Le Guan, Yong Xie, Yong Xie   +12 more
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Alternative cell death pathways and cell metabolism [PDF]

, 2013
While necroptosis has for long been viewed as an accidental mode of cell death triggered by physical or chemical damage, it has become clear over the last years that necroptosis can also represent a programmed form of cell death in mammalian cells.
Simone Fulda, Fulda, Simone
core   +1 more source

Repurposing of Ibrutinib and Quizartinib as potent inhibitors of necroptosis

Communications Biology, 2023
Necroptosis is a form of regulated cell death that has been implicated in multiple diseases. TNF-induced necroptosis is regulated by necrosomes, complexes consisting of RIPK1, RIPK3 and MLKL.
Fangmin Huang, Jiankun Liang, Yingying Lin, Yushi Chen, Fen Hu, Jianting Feng, Qiang Zeng, Zeteng Han, Qiaofa Lin, Yan Li, Jingyi Li, Lanqin Wu, Lisheng Li   +12 more
doaj   +1 more source

Interferon-γ Preferentially Promotes Necroptosis of Lung Epithelial Cells by Upregulating MLKL

Cells, 2022
Necroptosis, a form of programmed lytic cell death, has emerged as a driving factor in the pathogenesis of acute lung injury (ALI). As ALI is often associated with a cytokine storm, we determined whether pro-inflammatory cytokines modulate the ...
Qin Hao, Sreerama Shetty, Torry A. Tucker, Steven Idell, Hua Tang   +4 more
doaj   +1 more source