Results 31 to 40 of about 47,289 (162)
Regulated necrosis, a proinflammatory cell death, potentially counteracts pathogenic infections
Cell Death and Disease, 2022 Since the discovery of cell apoptosis, other gene-regulated cell deaths are gradually appreciated, including pyroptosis, ferroptosis, and necroptosis. Necroptosis is, so far, one of the best-characterized regulated necrosis.
Guangzhi Zhang +9 more
doaj +1 more source
Necroptosis and Neuroinflammation in Retinal Degeneration
Frontiers in Neuroscience, 2022 Necroptosis mediates the chronic inflammatory phenotype in neurodegeneration. Receptor-interacting protein kinase (RIPK) plays a pivotal role in the induction of necroptosis in various cell types, including microglia, and it is implicated in diverse ...
Yan Tao +3 more
doaj +1 more source
Methodology of drug screening and target identification for new necroptosis inhibitors
Journal of Pharmaceutical Analysis, 2019 Apoptosis has been considered as the only form of regulated cell death for a long time. However, a novel form of programmed cell death called necroptosis was recently reported.
Pengchao Pan +4 more
doaj +1 more source
, 2022 Necroptosis, a type of necrotic cell death independent of caspase regulation, is mainly mediated by receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).
Shuo Zheng (458517) +5 more
core +1 more source
The role of necroptosis in cancer biology and therapy
Molecular Cancer, 2019 Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is considered to be a promising approach to overcoming this problem ...
Yitao Gong +10 more
doaj +1 more source
, 2022 Necroptosis, a type of necrotic cell death independent of caspase regulation, is mainly mediated by receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).
Shuo Zheng (458517) +5 more
core +1 more source
, 2022 Necroptosis, a type of necrotic cell death independent of caspase regulation, is mainly mediated by receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).
Shuo Zheng (458517) +5 more
core +1 more source
, 2022 Necroptosis, a type of necrotic cell death independent of caspase regulation, is mainly mediated by receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).
Shuo Zheng (458517) +5 more
core +1 more source
Frontiers in Pharmacology, 2022 Objective: Necroptosis represents a new target for cancer immunotherapy and is considered a form of cell death that overcomes apoptosis resistance and enhances tumor immunogenicity.
Kun Fang +13 more
doaj +1 more source
Activation of necroptosis in human and experimental cholestasis
, 2016 Cholestasis encompasses liver injury and inflammation. Necroptosis, a necrotic cell death pathway regulated by receptor-interacting protein (RIP) 3, may mediate cell death and inflammation in the liver.
Afonso, Marta B +17 more
core +1 more source