Results 31 to 40 of about 34,308 (261)
Regulated necrosis, a proinflammatory cell death, potentially counteracts pathogenic infections
Cell Death and Disease, 2022 Since the discovery of cell apoptosis, other gene-regulated cell deaths are gradually appreciated, including pyroptosis, ferroptosis, and necroptosis. Necroptosis is, so far, one of the best-characterized regulated necrosis.
Guangzhi Zhang +9 more
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Methodology of drug screening and target identification for new necroptosis inhibitors
Journal of Pharmaceutical Analysis, 2019 Apoptosis has been considered as the only form of regulated cell death for a long time. However, a novel form of programmed cell death called necroptosis was recently reported.
Pengchao Pan +4 more
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TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor
Frontiers in Cell and Developmental Biology, 2020 As a programmed necrotic cell death, necroptosis has the intrinsic initiators, including receptor-interacting serine/threonine-protein kinase 1 (RIPK1), RIPK3 and mixed-lineage kinase domain-like protein (MLKL), which combine to form necroptotic ...
Lili Wang +5 more
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The role of necroptosis in cancer biology and therapy
Molecular Cancer, 2019 Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is considered to be a promising approach to overcoming this problem ...
Yitao Gong +10 more
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Vemurafenib inhibits necroptosis in normal and pathological conditions as a RIPK1 antagonist
Cell Death and Disease, 2023 Necroptosis, a programmed cell death with necrotic-like morphology, has been recognized as an important driver in various inflammatory diseases. Inhibition of necroptosis has shown potential promise in the therapy of multiple human diseases.
Mayu Sun +10 more
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Repurposing of Ibrutinib and Quizartinib as potent inhibitors of necroptosis
Communications Biology, 2023 Necroptosis is a form of regulated cell death that has been implicated in multiple diseases. TNF-induced necroptosis is regulated by necrosomes, complexes consisting of RIPK1, RIPK3 and MLKL.
Fangmin Huang +12 more
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The role of Ubiquitination in Apoptosis and Necroptosis [PDF]
Cell Death & Differentiation, 2021 AbstractCell death pathways have evolved to maintain tissue homoeostasis and eliminate potentially harmful cells from within an organism, such as cells with damaged DNA that could lead to cancer. Apoptosis, known to eliminate cells in a predominantly non-inflammatory manner, is controlled by two main branches, the intrinsic and extrinsic apoptotic ...
Jamie Z. Roberts +2 more
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Frontiers in Pharmacology, 2022 Objective: Necroptosis represents a new target for cancer immunotherapy and is considered a form of cell death that overcomes apoptosis resistance and enhances tumor immunogenicity.
Kun Fang +13 more
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The role of RHIM in necroptosis
Biochemical Society Transactions, 2022 The RIP homotypic interaction motif (RHIM) is a conserved protein domain that is approximately 18–22 amino acids in length. In humans, four proteins carrying RHIM domains have been identified: receptor-interacting serine/threonine protein kinase (RIPK) 1, RIPK3, Z-DNA-binding protein 1 (ZBP1), and TIR domain-containing adapter-inducing IFN-β (TRIF ...
Theresa Riebeling +2 more
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Non-canonical role of “S6K1–SGK1” pathway in neuronal necroptosis following traumatic brain injury
Genes and DiseasesTraumatic brain injury (TBI) is characterized by high rates of death and disability. Necroptosis is reported to be involved in neuronal death after TBI. However, additional molecules and related mechanisms underlying necroptosis, particularly during TBI,
Shuchao Wang +10 more
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