Results 11 to 20 of about 47,289 (162)

Repurposing of Ibrutinib and Quizartinib as potent inhibitors of necroptosis

Communications Biology, 2023
Necroptosis is a form of regulated cell death that has been implicated in multiple diseases. TNF-induced necroptosis is regulated by necrosomes, complexes consisting of RIPK1, RIPK3 and MLKL.
Fangmin Huang, Jiankun Liang, Yingying Lin, Yushi Chen, Fen Hu, Jianting Feng, Qiang Zeng, Zeteng Han, Qiaofa Lin, Yan Li, Jingyi Li, Lanqin Wu, Lisheng Li   +12 more
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The Function of Necroptosis and Its Treatment Target in IBD

Mediators of Inflammation
Inflammatory bowel disease (IBD), which encompasses Crohn’s disease (CD) and ulcerative colitis (UC), is a complicated illness whose exact cause is yet unknown.
Francis Atim Akanyibah, Yi Zhu, Tao Jin, Dickson Kofi Wiredu Ocansey, Fei Mao, Wei Qiu   +5 more
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The Role of Necroptosis in Cardiovascular Disease [PDF]

Frontiers in Pharmacology, 2018
A newly discovered mechanism of cell death, programmed necrosis (necroptosis), combines features of both necrosis and apoptosis. Necroptosis is tightly modulated by a series of characteristic signaling pathways. Activating necroptosis by ligands of death
Shi Zhe-Wei, Ge Li-Sha, Li Yue-Chun
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Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells [PDF]

, 2012
For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner.
Gabor Barna (146087), Pal I Bauer, Istvan Petak, Mihalik, Rudolf, Zsuzsanna A Dunai, Gergely Imre, Istvan Petak (5648680), Pal I. Bauer (144904), Gergely Imre (146083), Imre, Gergely, Tamas Korcsmaros, Dunai, Zsuzsanna A., Barna, Gabor, Rudolf Mihalik, Bauer, Pal I., Gabor Barna, Rudolf Mihalik (146097), Petak, Istvan, Zsuzsanna A. Dunai (144901), Korcsmaros, Tamas, Tamas Korcsmaros (146091), Dunai Zsuzsanna A., Barna Gabor, Petak Istvan, Mihalik Rudolf, Korcsmaros Tamas, Bauer Pal I., Imre Gergely   +27 more
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Necroptosis molecular mechanisms: recent findings regarding novel necroptosis regulators

, 2021
Necroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes, including swelling and membrane rupture, and release damage-associated ...
S Kim, Y W Nam, Jinho Seo, Doo-Byoung Oh, J Song   +4 more
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RIPK1-dependent necroptosis promotes vasculogenic mimicry formation via eIF4E in triple-negative breast cancer

Cell Death and Disease, 2023
Necroptosis is a caspase-independent form of programmed cell death. Receptor interacting protein kinase 1 (RIPK1) is a key molecule in the initiation of necroptosis and the formation of the necrotic complex.
Fan Li, Huizhi Sun, Yihui Yu, Na Che, Jiyuan Han, Runfen Cheng, Nan Zhao, Yuhong Guo, Chongbiao Huang, Danfang Zhang   +9 more
doaj   +1 more source

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]

, 2015
The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Dimitrios Stampoulis, M. Francesca Cordeiro, Williams, JA, Jennifer A. E. Williams, Stampoulis, D, Li Guo, Shi, H, Guo, L, Moss, SE, Francesca Cordeiro, M, Stephen E. Moss, Hui Shi   +11 more
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Necroptosis in Intestinal Inflammation and Cancer: New Concepts and Therapeutic Perspectives

Biomolecules, 2020
Necroptosis is a caspases-independent programmed cell death displaying intermediate features between necrosis and apoptosis. Albeit some physiological roles during embryonic development such tissue homeostasis and innate immune response are documented ...
Anna Negroni, Eleonora Colantoni, Salvatore Cucchiara, Laura Stronati   +3 more
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Identification of necroptosis-related features in diabetic nephropathy and analysis of their immune microenvironent and inflammatory response

Frontiers in Cell and Developmental Biology, 2023
Background: Diabetic nephropathy (DN) was considered a severe microvascular complication of diabetes, which was recognized as the second leading cause of end-stage renal diseases.
Kaibo Hu, Kaibo Hu, Ruifeng He, Ruifeng He, Minxuan Xu, Minxuan Xu, Minxuan Xu, Deju Zhang, Guangyu Han, Guangyu Han, Shengye Han, Shengye Han, Leyang Xiao, Leyang Xiao, Panpan Xia, Panpan Xia, Panpan Xia, Jitao Ling, Jitao Ling, Jitao Ling, Tingyu Wu, Tingyu Wu, Tingyu Wu, Fei Li, Fei Li, Fei Li, Yunfeng Sheng, Yunfeng Sheng, Yunfeng Sheng, Jing Zhang, Peng Yu, Peng Yu, Peng Yu   +32 more
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Intestinal epithelial cells necroptosis and its association with intestinal inflammation [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2019
This review focuses on the role of necroptosis, an alternative mode of cell death, in the pathogenesis of diseases associated with intestinal inflammation whose prevalence has been significantly increased for last decades, which substantiates the ...
Anton S. Tkachenko
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