Results 11 to 20 of about 52,832 (305)
The double-edged functions of necroptosis
Cell Death and Disease, 2023 Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it has been implicated in the pathogenesis of many diseases, there is evidence to support that necroptosis is not purely a detrimental process. We propose that
zhimin chen, Yanfang Xu
exaly +2 more sources
Targeting necroptosis in anticancer therapy: mechanisms and modulators
Acta Pharmaceutica Sinica B, 2020 Necroptosis, a genetically programmed form of necrotic cell death, serves as an important pathway in human diseases. As a critical cell-killing mechanism, necroptosis is associated with cancer progression, metastasis, and immunosurveillance.
Ying Wu, Guoqiang Dong, Chunquan Sheng
exaly +3 more sources
Frontiers in Genetics, 2022 Necroptosis, a type of necrotic cell death independent of caspase regulation, is mainly mediated by receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).
Yibo Ma +5 more
doaj +3 more sources
Necroptosis and Neuroinflammation in Retinal Degeneration
Frontiers in Neuroscience, 2022 Necroptosis mediates the chronic inflammatory phenotype in neurodegeneration. Receptor-interacting protein kinase (RIPK) plays a pivotal role in the induction of necroptosis in various cell types, including microglia, and it is implicated in diverse ...
Yan Tao +3 more
doaj +3 more sources
Necroptosis in Cholangiocarcinoma [PDF]
Cells, 2020 Necroptosis is a type of regulated cell death that is increasingly being recognized as a relevant pathway in different pathological conditions. Necroptosis can occur in response to multiple stimuli, is triggered by the activation of death receptors, and is regulated by receptor-interacting protein kinases 1 and 3 and mixed-lineage kinase domain-like ...
Sarcognato, S +4 more
openaire +4 more sources
Cell Death and Disease, 2021 Necroptosis is a form of regulated necrotic cell death that promotes inflammation. In cells undergoing necroptosis, activated RIPK1 kinase mediates the formation of RIPK1/RIPK3/MLKL complex to promote MLKL oligomerization and execution of necroptosis ...
Rui Zu +14 more
doaj +1 more source
p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3
Redox Biology, 2022 Mitochondrial dysfunction is a key contributor to necroptosis. We have investigated the contribution of p53, sulfiredoxin, and mitochondrial peroxiredoxin 3 to necroptosis in acute pancreatitis.
Sergio Rius-Pérez +3 more
doaj +1 more source
Cell, 2017 Necroptosis is a highly inflammatory form of programmed cell death that results from MLKL-mediated disruption of the cell membrane. In this issue of Cell, Gong et al. challenge the notion that MLKL activation is a point of no return by identifying mechanisms to counterbalance necroptosis, sustain plasma membrane integrity, and prolong cell viability.
Hongyan, Guo, William J, Kaiser
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Potential therapeutic value of necroptosis inhibitor for the treatment of COVID-19
European Journal of Medical Research, 2022 The coronavirus disease 2019 (COVID-19), caused by a novel virus of the beta-coronavirus genus (SARS-CoV-2), has spread rapidly, posing a significant threat to global health. There are currently no drugs available for effective treatment. Severe cases of
Yongan Kang, Qinghai Wang
doaj +1 more source
Frontiers in Genetics, 2022 The latest research suggesting that necroptosis plays a vital role in immune response. However, the influence of necroptosis on tumor microenvironment (TME) remodeling and immunotherapy is still unclear. We analyzed the variations in the expression of 26
Qiwei Wang +3 more
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