Results 11 to 20 of about 43,311 (200)
Necroptosis in Cholangiocarcinoma [PDF]
Cells, 2020 Necroptosis is a type of regulated cell death that is increasingly being recognized as a relevant pathway in different pathological conditions. Necroptosis can occur in response to multiple stimuli, is triggered by the activation of death receptors, and ...
Luca Fabris +11 more
core +7 more sources
Cell, 2014 Regulated necrosis, termed necroptosis, is mediated by the kinase activity of RIPK1 and RIPK3. It has distinct cellular features that are different than apoptosis.
Zhou, Wen, Yuan, Junying
core +3 more sources
, 2022 We downloaded different AML data cohorts with survival data to analysis the correlation in NRGs and prognosis of AML.
Cuiping Zheng (13209342)
core +2 more sources
Journal of Biomedical Science, 2019 Stress is deeply rooted in the modern society due to limited resources and large competition to achieve the desired goal. Women are more frequently exposed to several stressors during their reproductive age that trigger generation of reactive oxygen ...
Ashutosh N. Pandey +8 more
core +4 more sources
Necroptosis in development and diseases [PDF]
Genes & Development, 2018 Necroptosis, a form of regulated necrotic cell death mediated by RIPK1 (receptor-interacting protein kinase 1) kinase activity, RIPK3, and MLKL (mixed-lineage kinase domain-like pseudokinase), can be activated under apoptosis-deficient conditions ...
Junying Yuan +3 more
core +3 more sources
RIPK3 in necroptosis and cancer
Molecules and CellsReceptor-interacting protein kinase-3 is essential for the cell death pathway called necroptosis. Necroptosis is activated by the death receptor ligands and pattern recognition receptors of the innate immune system, leading to significant consequences in
Morgan, MJ, Kim, YS
core +3 more sources
The Role of Necroptosis in Cardiovascular Disease [PDF]
Frontiers in Pharmacology, 2018 A newly discovered mechanism of cell death, programmed necrosis (necroptosis), combines features of both necrosis and apoptosis. Necroptosis is tightly modulated by a series of characteristic signaling pathways. Activating necroptosis by ligands of death
Shi Zhe-Wei, Ge Li-Sha, Li Yue-Chun
doaj +2 more sources
Cell, 2017 Necroptosis is a highly inflammatory form of programmed cell death that results from MLKL-mediated disruption of the cell membrane. In this issue of Cell, Gong et al. challenge the notion that MLKL activation is a point of no return by identifying mechanisms to counterbalance necroptosis, sustain plasma membrane integrity, and prolong cell viability.
Hongyan, Guo, William J, Kaiser
openaire +2 more sources
JAK-STAT, 2012 TNF-induced necroptosis is caused by the activation of RIPK1 and the subsequent production of reactive oxygen species in the mitochondria, although the intermittent molecules of the signaling pathway responsible for this ROS-mediated type of programmed necrosis have not yet been identified.
Georgiadis, Vassilis, Knight, Richard A.
openaire +2 more sources
Ferroptosis and Necroptosis in the Kidney [PDF]
Cell Chemical Biology, 2020 In the last decade, the role of apoptosis in the pathophysiology of acute kidney injury (AKI) and AKI to chronic kidney disease (CKD) progression has been revisited as our understanding of ferroptosis and necroptosis has emerged. A growing body of evidence, reviewed here, ascribes a central pathophysiological role for ferroptosis and necroptosis to AKI,
Alexia, Belavgeni +4 more
openaire +2 more sources