Results 11 to 20 of about 34,308 (261)

Necroptosis and Neuroinflammation in Retinal Degeneration

Frontiers in Neuroscience, 2022
Necroptosis mediates the chronic inflammatory phenotype in neurodegeneration. Receptor-interacting protein kinase (RIPK) plays a pivotal role in the induction of necroptosis in various cell types, including microglia, and it is implicated in diverse ...
Yan Tao, Yusuke Murakami, Demetrios G. Vavvas, Koh-Hei Sonoda   +3 more
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Necroptosis in Cholangiocarcinoma [PDF]

Cells, 2020
Necroptosis is a type of regulated cell death that is increasingly being recognized as a relevant pathway in different pathological conditions. Necroptosis can occur in response to multiple stimuli, is triggered by the activation of death receptors, and is regulated by receptor-interacting protein kinases 1 and 3 and mixed-lineage kinase domain-like ...
Sarcognato, S, Jong, IEM, Fabris, L, Cadamuro, M, Guido, M   +4 more
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ESCRTing Necroptosis [PDF]

Cell, 2017
Necroptosis is a highly inflammatory form of programmed cell death that results from MLKL-mediated disruption of the cell membrane. In this issue of Cell, Gong et al. challenge the notion that MLKL activation is a point of no return by identifying mechanisms to counterbalance necroptosis, sustain plasma membrane integrity, and prolong cell viability.
Hongyan, Guo, William J, Kaiser
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Necroptosis [PDF]

JAK-STAT, 2012
TNF-induced necroptosis is caused by the activation of RIPK1 and the subsequent production of reactive oxygen species in the mitochondria, although the intermittent molecules of the signaling pathway responsible for this ROS-mediated type of programmed necrosis have not yet been identified.
Georgiadis, Vassilis, Knight, Richard A.
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Targeting necroptosis in fibrosis

Molecular Biology Reports, 2023
AbstractNecroptosis, a type of programmed cell death that resembles necrosis, is now known to depend on a different molecular mechanism from apoptosis, according to several recent studies. Many efforts have reported the possible influence of necroptosis in human disorders and concluded the crucial role in the pathophysiology of various diseases ...
Hassanein, Emad H. M., Ibrahim, Islam M., Abd El-Maksoud, Mostafa S., Abd El-Aziz, Mostafa K., Abd-alhameed, Esraa K., Althagafy, Hanan S.   +5 more
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A Glimpse of necroptosis and diseases

Biomedicine & Pharmacotherapy, 2022
Programmed cell death plays an important role in maintaining homeostasis. Necroptosis is a type of programmed cell death that has been recently discovered. It is mediated by RIPK1, RIPK3, and MLKL, and is characterized by necrotic cell morphology. Interestingly, the abnormal activation of necroptosis could lead to inflammation and a variety of diseases.
Ming, Yang, Wei, Chen, Liyu, He, Di, Liu, Li, Zhao, Xi, Wang   +5 more
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Phenytoin inhibits necroptosis [PDF]

Cell Death & Disease, 2018
AbstractReceptor-interacting protein kinases 1 and 3 (RIPK1/3) have best been described for their role in mediating a regulated form of necrosis, referred to as necroptosis. During this process, RIPK3 phosphorylates mixed lineage kinase domain-like (MLKL) to cause plasma membrane rupture.
von Mässenhausen, Anne, Tonnus, Wulf, Himmerkus, Nina, Parmentier, Simon, Saleh, Danish, Rodriguez, Diego, Ousingsawat, Jiraporn, Ang, Rosalind, Weinberg, Joel, Sanz, Ana, Ortiz, Alberto, Zierleyn, Adrian, Becker, Jan, Baratte, Blandine, Desban, Nathalie, Bach, Stéphane, Schiessl, Ina, Nogusa, Shoko, Balachandran, Siddharth, Anders, Hans, Ting, Adrian, Bleich, Markus, Degterev, Alexei, Kunzelmann, Karl, Bornstein, Stefan, Green, Douglas, Hugo, Christian, Linkermann, Andreas   +27 more
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Ferroptosis and Necroptosis in the Kidney [PDF]

Cell Chemical Biology, 2020
In the last decade, the role of apoptosis in the pathophysiology of acute kidney injury (AKI) and AKI to chronic kidney disease (CKD) progression has been revisited as our understanding of ferroptosis and necroptosis has emerged. A growing body of evidence, reviewed here, ascribes a central pathophysiological role for ferroptosis and necroptosis to AKI,
Alexia, Belavgeni, Claudia, Meyer, Julian, Stumpf, Christian, Hugo, Andreas, Linkermann   +4 more
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Necroptosis in Intestinal Inflammation and Cancer: New Concepts and Therapeutic Perspectives

Biomolecules, 2020
Necroptosis is a caspases-independent programmed cell death displaying intermediate features between necrosis and apoptosis. Albeit some physiological roles during embryonic development such tissue homeostasis and innate immune response are documented ...
Anna Negroni, Eleonora Colantoni, Salvatore Cucchiara, Laura Stronati   +3 more
doaj   +1 more source

Identification of necroptosis-related features in diabetic nephropathy and analysis of their immune microenvironent and inflammatory response

Frontiers in Cell and Developmental Biology, 2023
Background: Diabetic nephropathy (DN) was considered a severe microvascular complication of diabetes, which was recognized as the second leading cause of end-stage renal diseases.
Kaibo Hu, Kaibo Hu, Ruifeng He, Ruifeng He, Minxuan Xu, Minxuan Xu, Minxuan Xu, Deju Zhang, Guangyu Han, Guangyu Han, Shengye Han, Shengye Han, Leyang Xiao, Leyang Xiao, Panpan Xia, Panpan Xia, Panpan Xia, Jitao Ling, Jitao Ling, Jitao Ling, Tingyu Wu, Tingyu Wu, Tingyu Wu, Fei Li, Fei Li, Fei Li, Yunfeng Sheng, Yunfeng Sheng, Yunfeng Sheng, Jing Zhang, Peng Yu, Peng Yu, Peng Yu   +32 more
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