Results 21 to 30 of about 47,289 (162)
, 2022 Mixed lineage kinase domain-like pseudokinase (MLKL) is the terminal and indispensable mediator of necroptosis. Necroptosis, also known as programmed cell necrosis, is a caspase-independent cell death mechanism involved in various pathologic and ...
Chefetz, Ilana +2 more
core +1 more source
HNEAP Regulates Necroptosis of Cardiomyocytes by Suppressing the m5C Methylation of Atf7 mRNA
Advanced Science, 2023 PIWI‐interacting RNAs (piRNAs) are highly expressed in various cardiovascular diseases. However, their role in cardiomyocyte death caused by ischemia/reperfusion (I/R) injury, especially necroptosis, remains elusive.
Kai Wang +15 more
doaj +1 more source
Necroptosis and neutrophil-associated disorders. [PDF]
, 2018 Necroptosis is a form of regulated necrosis and is dependent on a signaling pathway involving receptor interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like protein (MLKL).
Simon, Hans-Uwe +8 more
core +2 more sources
Cell Reports, 2016 Tumor necrosis factor (TNF) induces necroptosis, a RIPK3/MLKL-dependent form of inflammatory cell death. In response to infection by Gram-negative bacteria, multiple receptors on macrophages, including TLR4, TNF, and type I IFN receptors, are ...
Diana Legarda +11 more
doaj +1 more source
Bibliometric analysis of publications on necroptosis from 2001 to 2021
Frontiers in Cell and Developmental Biology, 2022 Background: Necroptosis plays an important role in inflammation, cancer, and neurodegenerative diseases. In recent years, the number of studies related to necroptosis has increased and research has become increasingly in-depth.
Yang Liu +12 more
doaj +1 more source
Cell Death and Disease, 2021 Necroptosis has emerged as a novel and crucial player in acute and chronic liver diseases. Necroptotic cells lead to the release of DAMPs including S100A9, followed by the development of necroinflammation.
Li Bai +5 more
doaj +1 more source
Necroptosis: Molecular Signalling and Translational Implications [PDF]
, 2014 Necroptosis is a form of programmed necrosis whose molecular players are partially shared with apoptotic cell death. Here we summarize what is known about molecular signalling of necroptosis, particularly focusing on fine tuning of FLIP and IAP proteins
Donatella Starace +9 more
core +1 more source
, 2022 Necroptosis, a type of necrotic cell death independent of caspase regulation, is mainly mediated by receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).
Shuo Zheng (458517) +5 more
core +1 more source
Interferon-γ Preferentially Promotes Necroptosis of Lung Epithelial Cells by Upregulating MLKL
Cells, 2022 Necroptosis, a form of programmed lytic cell death, has emerged as a driving factor in the pathogenesis of acute lung injury (ALI). As ALI is often associated with a cytokine storm, we determined whether pro-inflammatory cytokines modulate the ...
Qin Hao +4 more
doaj +1 more source
, 2022 Necroptosis, a type of necrotic cell death independent of caspase regulation, is mainly mediated by receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).
Shuo Zheng (458517) +5 more
core +1 more source