Results 21 to 30 of about 52,832 (305)

Necroptosis in viral infections: a twilight among progeny dissemination and host defense [PDF]

Infectious Diseases and Tropical Medicine, 2023
Decades ago, a unique cell death pathway was reported, namely ‘Necroptosis’, that exhibits both the characteristics of apoptosis, the programmed cell death mechanism, as well as the unprogrammed necrotic cell death pathway.
S. Ghosh
doaj   +1 more source

Integrated stress response restricts macrophage necroptosis

Life Science Alliance, 2022
Stress inhibits necroptosis in a PERK-dependent manner via reduced RIPK1-RIPK3-MLKL signaling, showing an integral mechanistic connection between stress responses and programmed cell death.
David E Place, Parimal Samir, RK Subbarao Malireddi, Thirumala-Devi Kanneganti   +3 more
doaj   +1 more source

Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells [PDF]

, 2012
For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner.
Barna, Gabor, Bauer, Pal I., Dunai, Zsuzsanna A., Imre, Gergely, Korcsmaros, Tamas, Mihalik, Rudolf, Petak, Istvan   +6 more
core   +8 more sources

Necroptosis [PDF]

JAK-STAT, 2012
TNF-induced necroptosis is caused by the activation of RIPK1 and the subsequent production of reactive oxygen species in the mitochondria, although the intermittent molecules of the signaling pathway responsible for this ROS-mediated type of programmed necrosis have not yet been identified.
Georgiadis, Vassilis, Knight, Richard A.
openaire   +2 more sources

Targeting necroptosis in fibrosis

Molecular Biology Reports, 2023
AbstractNecroptosis, a type of programmed cell death that resembles necrosis, is now known to depend on a different molecular mechanism from apoptosis, according to several recent studies. Many efforts have reported the possible influence of necroptosis in human disorders and concluded the crucial role in the pathophysiology of various diseases ...
Hassanein, Emad H. M., Ibrahim, Islam M., Abd El-Maksoud, Mostafa S., Abd El-Aziz, Mostafa K., Abd-alhameed, Esraa K., Althagafy, Hanan S.   +5 more
openaire   +2 more sources

A Glimpse of necroptosis and diseases

Biomedicine & Pharmacotherapy, 2022
Programmed cell death plays an important role in maintaining homeostasis. Necroptosis is a type of programmed cell death that has been recently discovered. It is mediated by RIPK1, RIPK3, and MLKL, and is characterized by necrotic cell morphology. Interestingly, the abnormal activation of necroptosis could lead to inflammation and a variety of diseases.
Ming, Yang, Wei, Chen, Liyu, He, Di, Liu, Li, Zhao, Xi, Wang   +5 more
openaire   +2 more sources

A novel necroptosis-related lncRNAs signature effectively predicts the prognosis for osteosarcoma and is associated with immunity

Frontiers in Pharmacology, 2022
Background: Necroptosis is closely related to tumorigenesis and development. Accumulating evidence has revealed that long non-coding RNAs (lncRNAs) are also central players in osteosarcoma (OS).
Binfeng Liu, Binfeng Liu, Chengyao Feng, Chengyao Feng, Zhongyue Liu, Zhongyue Liu, Chao Tu, Chao Tu, Zhihong Li, Zhihong Li   +9 more
doaj   +1 more source

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]

, 2020
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien, de Reuver, Richard, Declercq, Wim, Devos, Michael, Dierick, Evelien, Gilbert, Barbara, Lefebvre, Sylvie, Maelfait, Jonathan, Nemegeer, Josephine, Rehwinkel, Jan, Tanghe, Giel, Vandenabeele, Peter, Verheirstraeten, Maud   +12 more
core   +2 more sources

Phenytoin inhibits necroptosis [PDF]

Cell Death & Disease, 2018
AbstractReceptor-interacting protein kinases 1 and 3 (RIPK1/3) have best been described for their role in mediating a regulated form of necrosis, referred to as necroptosis. During this process, RIPK3 phosphorylates mixed lineage kinase domain-like (MLKL) to cause plasma membrane rupture.
von Mässenhausen, Anne, Tonnus, Wulf, Himmerkus, Nina, Parmentier, Simon, Saleh, Danish, Rodriguez, Diego, Ousingsawat, Jiraporn, Ang, Rosalind, Weinberg, Joel, Sanz, Ana, Ortiz, Alberto, Zierleyn, Adrian, Becker, Jan, Baratte, Blandine, Desban, Nathalie, Bach, Stéphane, Schiessl, Ina, Nogusa, Shoko, Balachandran, Siddharth, Anders, Hans, Ting, Adrian, Bleich, Markus, Degterev, Alexei, Kunzelmann, Karl, Bornstein, Stefan, Green, Douglas, Hugo, Christian, Linkermann, Andreas   +27 more
openaire   +3 more sources

Ferroptosis and Necroptosis in the Kidney [PDF]

Cell Chemical Biology, 2020
In the last decade, the role of apoptosis in the pathophysiology of acute kidney injury (AKI) and AKI to chronic kidney disease (CKD) progression has been revisited as our understanding of ferroptosis and necroptosis has emerged. A growing body of evidence, reviewed here, ascribes a central pathophysiological role for ferroptosis and necroptosis to AKI,
Alexia, Belavgeni, Claudia, Meyer, Julian, Stumpf, Christian, Hugo, Andreas, Linkermann   +4 more
openaire   +2 more sources