Results 21 to 30 of about 43,311 (200)

Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease [PDF]

, 2022
Alzheimer’s disease (AD) is a major adult-onset neurodegenerative condition with no available treatment. Compelling reports point amyloid-β (Aβ) as the main etiologic agent that triggers AD.
Court, Felipe A, Vitorica Ferrández, Francisco Javier, Gámez, Nazaret, Escandón, Marcela, Court, Felipe A., Quiroz, Gabriel, Moreno-González, Inés, Gutiérrez, Antonia, Jiménez, Sebastián, Jiménez Muñoz, Sebastián, Vegas Gómez, Laura, Vegas-Gómez, Laura, Gutiérrez-Pérez, Antonia, Vitorica, Javier, Gutiérrez Pérez, Antonia, Soto, Claudio, Salvadores, Natalia, Moreno González, Inés, Escandón, Marcelo, Vitorica Ferrández, Javier   +19 more
core   +1 more source

Necroptosis and neutrophil-associated disorders. [PDF]

, 2018
Necroptosis is a form of regulated necrosis and is dependent on a signaling pathway involving receptor interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like protein (MLKL).
Simon, Hans-Uwe, Hans-Uwe Simon, Shida Yousefi, Yousefi, Shida, Xiaoliang Wang, Wang, Xiaoliang   +5 more
core   +3 more sources

Necroptosis in the Pathophysiology of Disease [PDF]

The American Journal of Pathology, 2020
Over the past 15 years, elegant studies have demonstrated that in certain conditions, programed cell death resembles necrosis and depends on a unique molecular pathway with no overlap with apoptosis. This form of regulated necrosis is represented by necroptosis, in which the receptor-interacting protein kinase-3 and its substrate mixed-lineage kinase ...
Mitri K. Khoury, Kartik Gupta, Sarah R. Franco, Bo Liu   +3 more
openaire   +2 more sources

Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells [PDF]

, 2012
For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner.
Gabor Barna (146087), Pal I Bauer, Istvan Petak, Mihalik, Rudolf, Zsuzsanna A Dunai, Gergely Imre, Istvan Petak (5648680), Pal I. Bauer (144904), Gergely Imre (146083), Imre, Gergely, Tamas Korcsmaros, Dunai, Zsuzsanna A., Barna, Gabor, Rudolf Mihalik, Bauer, Pal I., Gabor Barna, Rudolf Mihalik (146097), Petak, Istvan, Zsuzsanna A. Dunai (144901), Korcsmaros, Tamas, Tamas Korcsmaros (146091)   +20 more
core   +2 more sources

Phenytoin inhibits necroptosis [PDF]

Cell Death & Disease, 2018
AbstractReceptor-interacting protein kinases 1 and 3 (RIPK1/3) have best been described for their role in mediating a regulated form of necrosis, referred to as necroptosis. During this process, RIPK3 phosphorylates mixed lineage kinase domain-like (MLKL) to cause plasma membrane rupture.
von Mässenhausen, Anne, Tonnus, Wulf, Himmerkus, Nina, Parmentier, Simon, Saleh, Danish, Rodriguez, Diego, Ousingsawat, Jiraporn, Ang, Rosalind, Weinberg, Joel, Sanz, Ana, Ortiz, Alberto, Zierleyn, Adrian, Becker, Jan, Baratte, Blandine, Desban, Nathalie, Bach, Stéphane, Schiessl, Ina, Nogusa, Shoko, Balachandran, Siddharth, Anders, Hans, Ting, Adrian, Bleich, Markus, Degterev, Alexei, Kunzelmann, Karl, Bornstein, Stefan, Green, Douglas, Hugo, Christian, Linkermann, Andreas   +27 more
openaire   +3 more sources

Necroptosis in Intestinal Inflammation and Cancer: New Concepts and Therapeutic Perspectives

Biomolecules, 2020
Necroptosis is a caspases-independent programmed cell death displaying intermediate features between necrosis and apoptosis. Albeit some physiological roles during embryonic development such tissue homeostasis and innate immune response are documented ...
Anna Negroni, Eleonora Colantoni, Salvatore Cucchiara, Laura Stronati   +3 more
doaj   +1 more source

RIPK1-dependent necroptosis promotes vasculogenic mimicry formation via eIF4E in triple-negative breast cancer

Cell Death and Disease, 2023
Necroptosis is a caspase-independent form of programmed cell death. Receptor interacting protein kinase 1 (RIPK1) is a key molecule in the initiation of necroptosis and the formation of the necrotic complex.
Fan Li, Huizhi Sun, Yihui Yu, Na Che, Jiyuan Han, Runfen Cheng, Nan Zhao, Yuhong Guo, Chongbiao Huang, Danfang Zhang   +9 more
doaj   +1 more source

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]

, 2015
The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Dimitrios Stampoulis, M. Francesca Cordeiro, Williams, JA, Jennifer A. E. Williams, Stampoulis, D, Li Guo, Shi, H, Guo, L, Moss, SE, Francesca Cordeiro, M, Stephen E. Moss, Hui Shi   +11 more
core   +1 more source

RIPK3: Beyond Necroptosis [PDF]

Immunity, 2019
In this issue of Immunity, Daniels et al. (2019) demonstrate that RIPK3 signaling limits Zika virus (ZIKV) infection in the central nervous system independently of its function in necroptosis by promoting itaconate production in infected neurons, thereby revealing a neuron-specific mechanism of metabolite-mediated ZIKV control.
Evans, Azia S, Coyne, Carolyn B
openaire   +2 more sources

Identification of necroptosis-related features in diabetic nephropathy and analysis of their immune microenvironent and inflammatory response

Frontiers in Cell and Developmental Biology, 2023
Background: Diabetic nephropathy (DN) was considered a severe microvascular complication of diabetes, which was recognized as the second leading cause of end-stage renal diseases.
Kaibo Hu, Kaibo Hu, Ruifeng He, Ruifeng He, Minxuan Xu, Minxuan Xu, Minxuan Xu, Deju Zhang, Guangyu Han, Guangyu Han, Shengye Han, Shengye Han, Leyang Xiao, Leyang Xiao, Panpan Xia, Panpan Xia, Panpan Xia, Jitao Ling, Jitao Ling, Jitao Ling, Tingyu Wu, Tingyu Wu, Tingyu Wu, Fei Li, Fei Li, Fei Li, Yunfeng Sheng, Yunfeng Sheng, Yunfeng Sheng, Jing Zhang, Peng Yu, Peng Yu, Peng Yu   +32 more
doaj   +1 more source