Results 101 to 110 of about 17,178,165 (354)

Zinc Finger Transcription Factor MZF1—A Specific Regulator of Cancer Invasion

Cells, 2020
Over 90% of cancer deaths are due to cancer cells metastasizing into other organs. Invasion is a prerequisite for metastasis formation. Thus, inhibition of invasion can be an efficient way to prevent disease progression in these patients.
Ditte Marie Brix, Knut Kristoffer Bundgaard Clemmensen, Tuula Kallunki   +2 more
doaj   +1 more source

Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner. [PDF]

, 2017
Glioblastoma is associated with a poor overall survival despite new treatment advances. Antiangiogenic strategies targeting VEGF based on tyrosine kinase inhibitors (TKIs) are currently undergoing extensive research for the treatment of glioma.
Amantini, C, BERNARDINI, Giovanni, CARDINALI, CLAUDIO, MORELLI, MARIA BEATRICE, Nabissi, M, SANTONI, Angela, Santoni, G., Santoni, M   +7 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Need for standardization of Influenza A virus-induced cell death in vivo to improve consistency of inter-laboratory research findings

Cell Death Discovery
The involvement of necroptosis in the control of influenza A virus (IAV) infection has been reported in multiple studies. Downstream of the nucleic acid sensor ZBP1, RIPK3 kinase activity is critically involved in the induction of necroptotic cell death ...
Teodora Oltean, Jonathan Maelfait, Xavier Saelens, Peter Vandenabeele   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Role of Mitochondrial Iron Uptake in Acetaminophen Hepatotoxicity

Livers
Overdose of acetaminophen (APAP) produces fulminant hepatic necrosis. The underlying mechanism of APAP hepatotoxicity involves mitochondrial dysfunction, including mitochondrial oxidant stress and the onset of mitochondrial permeability transition (MPT).
Jiangting Hu, Anna-Liisa Nieminen, Zhi Zhong, John J. Lemasters   +3 more
doaj   +1 more source

The effect of phagocytosis of poly(L-lactic acid) fragments on cellular morphology and viability [PDF]

, 1993
The aim of this study was to investigate the effect of phagocytosed poly(L-lactic acid) particles on the morpholgy and viability of phagocytes, mainly macrophages. Therefore, predegraded poly(L-lactic acid) (P-PLLA) and nontreated PLLA (N-PLLA) particles,
Anderson, Bakker, Beller, Blaauw, Cotran, Hassan, Holmes, Hulsteart, Karnovsky, Kotani, Kotani, Lam, Marchant, Matlaga, McInnes, Most, Papadimitriou, Pizzoferrato, Rozema, Schakenraad, Schakenraad, Schindler, Schkenraad, Schnyder, Springer, van Wachem   +25 more
core   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Recent advances in understanding inhibitor of apoptosis proteins [version 1; referees: 2 approved]

F1000Research, 2018
The inhibitor of apoptosis proteins (IAPs) are a family of proteins that were chiefly known for their ability to inhibit apoptosis by blocking caspase activation or activity.
Najoua Lalaoui, David Lawrence Vaux
doaj   +1 more source

Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production [PDF]

, 2016
Self-tolerance and immunity are actively acquired in parallel through a poorly understood ability of antigen receptors to switch between signaling death or proliferation of antigenbinding lymphocytes in different contexts.
Domaschenz, Heather, Fung, Herman, Goodnow, Christopher, Horikawa, Keisuke, Jeelall, Yogeshraj, Kallies, Axel, Law, Hsei-Di, Nutt, Stephen L, Wang, James   +8 more
core   +1 more source