Results 111 to 120 of about 2,113,177 (314)

Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor

, 2011
Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating bacterial diarrhea and intestinal parasite infections. Although berberine has recently been shown to suppress growth of several tumor cell lines, information ...
Tianhui Hu, Rupesh Chaturvedi, Yan Shi, Hamwei Cao, Fang Yan, Lihong Wang, Liping Liu, Keith Wilson, D. Brent Polk   +8 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Monoamine oxidase in neuronal cell death

, 2008
Monoamine oxidase (MAO) is an oxidative enzyme that deaminates a variety of amine substrates, including the neurotransmitter dopamine. The enzymatic reaction requires molecular oxygen and produces hydrogen peroxide as a by-product.
Fitzgerald, J
core  

Measles virus causes immunogenic cell death in human melanoma

, 2011
NoOncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models of human melanoma.
Russell, S, Selby, P., Hadac, E., Donnelly, Oliver G, Jennings, V., Errington-Mais, F., Melcher, Alan A, Hadac, Elizabeth, Bond, J, Melcher, A.A., Bond, Jacquelyn, Selby, P, Bond, J., Peach, H., Vile, Richard, Steele, L., Vile, R., Hadac, E, Donnelly, O.G., Russell, Stephen, Harrington, K.J., Harrington, K, Peach, Howard, Steele, Lynette, Melcher, AA, Errington-Mais, Fiona, Harrington, Kevin, Russell, S., Phillips, Roger M., Pandha, H.S., Selby, Peter, Errington-Mais, F, Jennings, V, Scott, K, Phillips, RM, Phillips, Roger M, Scott, K., Pandha, Hardev, Vile, R, Jennings, Victoria, Steele, L, Pandha, H, Scott, Karen, Donnelly, OG, Peach, H   +44 more
core   +1 more source

Membrane-tethering of cytochrome c accelerates regulated cell death in yeast

, 2020
Intrinsic apoptosis as a modality of regulated cell death is intimately linked to permeabilization of the outer mitochondrial membrane and subsequent release of the protein cytochrome c into the cytosol, where it can participate in caspase activation via
Büttner, Sabrina, Toth, Alexandra,, Aufschnaiter, Andreas, Büttner, Sabrina,, Dawitz, Hannah,, Ott, Martin,, Ädelroth, Pia,, Aufschnaiter, Andreas,, Toth, Alexandra, Ädelroth, Pia, Fedotovskaya, Olga,, Fedotovskaya, Olga, Ott, Martin, Dawitz, Hannah   +13 more
core   +1 more source

Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts. [PDF]

, 2012
The inhibition of death-receptor apoptosis is a conserved viral function. The murine cytomegalovirus (MCMV) gene M36 is a sequence and functional homologue of the human cytomegalovirus gene UL36, and it encodes an inhibitor of apoptosis that binds to ...
Ebermann, L., Čičin-Šain, Luka, Luka Čičin-Šain, Rosaely Casalegno-Garduño (111456), Carlos A Guzmán, Ruzsics, Zsolt, van Rooijen, Nico, Koszinowski, U., van Rooijen, N., Ulrich Koszinowski, Linda Ebermann (111451), Zsolt Ruzsics (75383), Ruzsics, Z., Nico van Rooijen, Guzman, C.A., Casalegno-Garduno, R., Ulrich Koszinowski (111457), Ruzsics Zsolt, Casalegno-Garduño, Rosaely, Nico van Rooijen (4110211), Koszinowski, Ulrich H., Zsolt Ruzsics, Carlos A. Guzmán (111454), Luka Čičin-Šain (111459), Guzmán, Carlos A., Rooijen, N. van, Guzmán Carlos A., Ebermann Linda, Linda Ebermann, Cicin-Sain, L., Čičin-Šain Luka, Guzmán, Carlos A, Casalegno-Garduño Rosaely, Koszinowski, Ulrich, Rosaely Casalegno-Garduño, Ebermann, Linda, van Rooijen Nico, Koszinowski Ulrich   +37 more
core   +1 more source

Mitochondrial Oxidative Stress and Antioxidants Balance in Fatty Liver Disease

Hepatology Communications, 2018
Fatty liver disease is one of the most prevalent forms of chronic liver disease that encompasses both alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD).
Carmen García‐Ruiz, José C. Fernández‐Checa   +1 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Epigenetic Rewiring of Protein Kinase Signalling in T-Cell Acute Lymphoblastic Leukaemia

Kinases and Phosphatases
T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive neoplastic malignancy characterised by the accumulation of multiple oncogenic and epigenetic alterations in haematopoietic T-cell precursors leading to their uncontrolled proliferation and ...
Claudina A. Pérez-Novo, Amber Driesen, Maaike Van Trimpont, Claudia Theys, Emilie Logie, Pieter Van Vlierberghe, Wim Vanden Berghe   +6 more
doaj   +1 more source