Results 51 to 60 of about 17,178,165 (354)

The molecular machinery of regulated cell death

open access: yesCell Research, 2019
Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms.
D. Tang   +4 more
semanticscholar   +1 more source

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 [PDF]

open access: yes, 2014
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as ‘accidental cell death’ (ACD).
A Ciechanover   +438 more
core   +17 more sources

Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases

open access: yesCell Death Discovery, 2021
Ferroptosis, a recently identified and iron-dependent cell death, differs from other cell death such as apoptosis, necroptosis, pyroptosis, and autophagy-dependent cell death. This form of cell death does not exhibit typical morphological and biochemical
Yi Yu   +10 more
semanticscholar   +1 more source

Legionella pneumophila strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin [PDF]

open access: yes, 2017
International audienceThe human pathogen Legionella pneumophila must evade host cell death signaling to enable replication in lung macrophages and to cause disease. After bacterial growth, however, L.
Abraham, Gilu   +10 more
core   +4 more sources

Cell death due to electroporation - A review.

open access: yesBioelectrochemistry, 2021
Exposure of cells to high voltage electric pulses increases transiently membrane permeability through membrane electroporation. Electroporation can be reversible and is used in gene transfer and enhanced drug delivery but can also lead to cell death ...
Tina Batista Napotnik   +2 more
semanticscholar   +1 more source

Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death. [PDF]

open access: yes, 2013
BackgroundVertebrate genomes undergo epigenetic reprogramming during development and disease. Emerging evidence suggests that DNA methylation plays a key role in cell fate determination in the retina.
Enke, Raymond A   +5 more
core   +5 more sources

SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway

open access: yesCell Death and Disease, 2023
SIRT1 (NAD-dependent protein deacetylase sirtuin-1), a class III histone deacetylase acting as a tumor suppressor gene, is downregulated in oral cancer cells.
Srimanta Patra   +8 more
doaj   +1 more source

Ursolic Acid Impairs Cellular Lipid Homeostasis and Lysosomal Membrane Integrity in Breast Carcinoma Cells

open access: yesCells, 2022
Cancer is one of the leading causes of death worldwide, thus the search for new cancer therapies is of utmost importance. Ursolic acid is a naturally occurring pentacyclic triterpene with a wide range of pharmacological activities including anti ...
Ditte L. Fogde   +9 more
doaj   +1 more source

RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer [PDF]

open access: yes, 2018
Purpose: Alteration in cell death is a hallmark of cancer. A functional role regulating survival, apoptosis, and necroptosis has been attributed to RIP1/3 complexes.Experimental Design: We have investigated the role of RIP1 and the effects of MC2494 in ...
A. Baldi   +23 more
core   +2 more sources

Molecular mechanisms of cell death in neurological diseases

open access: yesCell Death and Differentiation, 2021
Tightly orchestrated programmed cell death (PCD) signalling events occur during normal neuronal development in a spatially and temporally restricted manner to establish the neural architecture and shaping the CNS. Abnormalities in PCD signalling cascades,
Diane Moujalled   +2 more
semanticscholar   +1 more source

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