Cells, 2022 The recent discovery demonstrating that the leakage of cathepsin B from mitotic lysosomes assists mitotic chromosome segregation indicates that lysosomal membrane integrity can be spatiotemporally regulated.
Jonathan Stahl-Meyer +4 more
doaj +1 more source
p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death [PDF]
, 2005 In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to the cell cycle during neuronal death are still unclear.
Sambo, Anne-Véronique +15 more
core +1 more source
Ferroptosis: friend or foe in cancer immunotherapy?
OncoImmunology, 2023 Ferroptosis has gained interest due to it immunogenicity and the higher sensitivity of cancer cells to it. However, it was recently shown that ferroptosis in tumor-associated neutrophils leads to immunosuppression and negatively impacts therapy. Here, we
Robin Demuynck +3 more
doaj +1 more source
Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death [PDF]
, 2006 Histolysis refers to a widespread disintegration of tissues that is morphologically distinct from apoptosis and often associated with the stimulation of autophagy. Here, we establish that a component of the apoptosome, and pivotal regulator of apoptosis,
Xiaodong Wang +27 more
core +1 more source
Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines
Cell Death and Disease, 2021 Sorafenib, a protein kinase inhibitor approved for the treatment of hepatocellular carcinoma and advanced renal cell carcinoma, has been repeatedly reported to induce ferroptosis by possibly involving inhibition of the cystine/glutamate antiporter, known
Jiashuo Zheng +5 more
doaj +1 more source
Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death [PDF]
, 2003 Caspase-directed apoptosis usually fragments cells, releasing nonfunctional, prothrombogenic, membrane-bound apoptotic bodies marked for rapid engulfment by macrophages.
Jones, David B. +12 more
core +1 more source
Regulation of cell death in cancer - possible implications for immunotherapy [PDF]
, 2013 Since most anticancer therapies including immunotherapy trigger programmed cell death in cancer cells, defective cell death programs can lead to treatment resistance and tumor immune escape.
Simone Fulda +2 more
core +1 more source
Programmed cell death in type II neuroblast lineages is required for central complex development in the Drosophila brain [PDF]
, 2012 Background: The number of neurons generated by neural stem cells is dependent upon the regulation of cell proliferation and by programmed cell death.
Heinrich Reichert +7 more
core +1 more source
Strategies for vascularization in kidney organoids [PDF]
Organoid, 2022 The establishment of protocols for differentiating kidney organoids from human pluripotent stem cells (hPSCs) has potential for the application of kidney organoids in regenerative medicine. However, the primary obstacle to the regenerative application of
Seo-Yeon Park, Yong Kyun Kim
doaj +1 more source
The mutualistic fungus Piriformospora indica colonizes Arabidopsis roots by inducing an endoplasmic reticulum stress-triggered caspase-dependent cell death [PDF]
, 2012 In Arabidopsis thaliana roots, the mutualistic fungus Piriformospora indica initially colonizes living cells, which die as the colonization proceeds. We aimed to clarify the molecular basis of this colonization-associated cell death.
Zechmann, B. +4 more
core +1 more source