Results 11 to 20 of about 17,178,165 (354)
Antioxidants Threaten Multikinase Inhibitor Efficacy against Liver Cancer by Blocking Mitochondrial Reactive Oxygen Species
Antioxidants, 2021 Sorafenib and regorafenib, multikinase inhibitors (MKIs) used as standard chemotherapeutic agents for hepatocellular carcinoma (HCC), generate reactive oxygen species (ROS) during cancer treatment.Blanca Cucarull, Anna Tutusaus, Tania Hernáez-Alsina, Pablo García de Frutos, María Reig, Anna Colell, Montserrat Marí, Albert Morales +7 moredoaj +1 more sourceNeuronal Cell Death [PDF]
Neuron, 1998 We thank J.-F. Brunet, P. G. H. Clarke, O. deLapeyriere, P. Golstein, J.-C. Martinou, C. Mulle, and R. W. Oppenheim for thoughtful comments on the manuscript and C. Waldmann for artwork. In a short review such as this, it is not possible to establish precedence for all ideas or mechanisms, many of which originate from (or are still confined to) studies Pettmann, Brigitte, Henderson, Christopher E +1 moreopenaire +2 more sourcesCopper metabolism in cell death and autophagy
Autophagy, 2023 Copper is an essential trace element in biological systems, maintaining the activity of enzymes and the function of transcription factors. However, at high concentrations, copper ions show increased toxicity by inducing regulated cell death, such as ...Qian Xue, Rui Kang, D. Klionsky, D. Tang, Jinbao Liu, Xin Chen +5 moresemanticscholar +1 more sourceApoptotic cell death in disease—Current understanding of the NCCD 2023
Cell Death and Differentiation, 2023 Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this ...I. Vitale, F. Pietrocola, Emma Guilbaud, Stuart A Aaronson, J. Abrams, D. Adam, M. Agostini, P. Agostinis, E. Alnemri, L. Altucci, I. Amelio, D. Andrews, R. Aqeilan, E. Arama, E. Baehrecke, Siddharth Balachandran, D. Bano, N. Barlev, J. Bartek, N. Bazan, C. Becker, F. Bernassola, M. Bertrand, M. Bianchi, M. V. Blagosklonny, J. Blander, G. Blandino, K. Blomgren, C. Borner, C. Bortner, P. Bove, P. Boya, C. Brenner, P. Brož, T. Brunner, R. Damgaard, G. Calin, M. Campanella, E. Candi, M. Carbone, D. Carmona‐Gutierrez, F. Cecconi, F. K. Chan, Guoqiang Chen, Quan Chen, Youhai H. Chen, E. Cheng, J. Chipuk, J. Cidlowski, A. Ciechanover, G. Ciliberto, M. Conrad, J. Cubillos-Ruiz, P. Czabotar, V. D’Angiolella, M. Daugaard, T. Dawson, V. Dawson, R. De Maria, B. de Strooper, K. Debatin, R. Deberardinis, A. Degterev, G. Del Sal, M. Deshmukh, F. Di Virgilio, M. Diederich, Scott J. Dixon, B. Dynlacht, W. El-Deiry, J. Elrod, K. Engeland, G. Fimia, C. Galassi, C. Ganini, A. García-Sáez, Abhishek D Garg, C. Garrido, E. Gavathiotis, M. Gerlic, Sourav Ghosh, D. Green, L. Greene, H. Gronemeyer, G. Häcker, G. Hajnóczky, J. Hardwick, Y. Haupt, Sudan He, D. Heery, M. Hengartner, C. Hetz, David A Hildeman, H. Ichijo, Satoshi Inoue, M. Jäättelä, Ana Janic, B. Joseph, Philipp J Jost, T. Kanneganti, M. Karin, H. Kashkar, T. Kaufmann, Gemma L. Kelly, O. Kepp, A. Kimchi, R. Kitsis, D. Klionsky, R. Kluck, D. Krysko, D. Kulms, Sharad Kumar, S. Lavandero, I. Lavrik, J. Lemasters, Gianmaria Liccardi, A. Linkermann, S. Lipton, R. Lockshin, C. López-Otín, T. Luedde, M. MacFarlane, F. Madeo, W. Malorni, G. Manic, R. Mantovani, S. Marchi, J. Marine, S. Martin, J. Martinou, P. Mastroberardino, J. Medema, P. Mehlen, P. Meier, G. Melino, S. Melino, Edward A. Miao, U. Moll, C. Muñoz-Pinedo, D. Murphy, M. Niklison-Chirou, F. Novelli, G. Núñez, A. Oberst, D. Ofengeim, J. Opferman, M. Oren, M. Pagano, T. Panaretakis, M. Pasparakis, J. Penninger, F. Pentimalli, David M. Pereira, S. Pervaiz, M. Peter, P. Pinton, Giovanni Porta, J. Prehn, H. Puthalakath, G. Rabinovich, K. Rajalingam, K. Ravichandran, M. Rehm, J. Ricci, R. Rizzuto, N. Robinson, C. Rodrigues, B. Rotblat, C. Rothlin, D. Rubinsztein, T. Rudel, A. Rufini, K. Ryan, K. Sarosiek, A. Sawa, E. Sayan, K. Schroder, L. Scorrano, F. Sesti, F. Shao, Yufang Shi, G. Sica, J. Silke, H. Simon, A. Sistigu, A. Stephanou, B. Stockwell, Flavie Strapazzon, A. Strasser, Liming Sun, E. Sun, Qiang Sun, G. Szabadkai, S. Tait, D. Tang, Nektarios Tavernarakis, C. Troy, B. Turk, N. Urbano, P. Vandenabeele, T. Vanden Berghe, M. V. Vander Heiden, J. Vanderluit, A. Verkhratsky, A. Villunger, Silvia von Karstedt, A. Voss, K. Vousden, D. Vučić, Daniela Vuri, E. Wagner, H. Walczak, D. Wallach, Ruoning Wang, Ying Wang, Achim Weber, Will Wood, T. Yamazaki, Huang-Tian Yang, Z. Zakeri, J. Zawacka-Pankau, Lin Zhang, Haibing Zhang, B. Zhivotovsky, Wenzhao Zhou, M. Piacentini, G. Kroemer, L. Galluzzi +227 moresemanticscholar +1 more sourceAutophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation [PDF]
, 2020 Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses downstream of TNFR1 and other receptors, and has been implicated in the pathogenesis of inflammatory and degenerative diseases.Bertrand, Mathieu, Corona, Teresa, Delanghe, Tom, Kondylis, Vangelis, Krüger, Marcus, Kumari, Snehlata, Laurien, Lucie, Nagata, Masahiro, Pasparakis, Manolis, Schwarzer, Robin, Schünke, Hannah, Wiederstein, Janica L. +11 morecore +1 more sourceCell Death Signaling [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 In multicellular organisms, cell death is a critical and active process that maintains tissue homeostasis and eliminates potentially harmful cells. There are three major types of morphologically distinct cell death: apoptosis (type I cell death), autophagic cell death (type II), and necrosis (type III).Douglas R, Green, Fabien, Llambiopenaire +2 more sourcesIonizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death
Cell Death and Disease, 2020 Radiotherapy is commonly used as a cytotoxic treatment of a wide variety of tumors. Interestingly, few case reports underlined its potential to induce immune-mediated abscopal effects, resulting in regression of metastases, distant from the irradiated ...Sandy Adjemian, Teodora Oltean, Sofie Martens, Bartosz Wiernicki, Vera Goossens, Tom Vanden Berghe, Benjamin Cappe, Maria Ladik, Franck B. Riquet, Liesbeth Heyndrickx, Jolien Bridelance, Marnik Vuylsteke, Katrien Vandecasteele, Peter Vandenabeele +13 moredoaj +1 more sourceFerroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.
Cell, 2017 Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of ...B. Stockwell, J. Angeli, H. Bayır, A. Bush, M. Conrad, S. Dixon, S. Fulda, S. Gascón, Stavroula K. Hatzios, V. Kagan, Kay Noel, Xuejun Jiang, A. Linkermann, M. Murphy, M. Overholtzer, Atsushi Oyagi, G. Pagnussat, Jason Park, Qitao Ran, C. Rosenfeld, K. Salnikow, Daolin Tang, Daolin Tang, F. Torti, S. Torti, S. Toyokuni, K. Woerpel, Donna D. Zhang +27 moresemanticscholar +1 more sourceDiversity and complexity of cell death: a historical review
Experimental and Molecular Medicine, 2023 Death is the inevitable fate of all living organisms, whether at the individual or cellular level. For a long time, cell death was believed to be an undesirable but unavoidable final outcome of nonfunctioning cells, as inflammation was inevitably ...Wonyoung Park, Shibo Wei, Bo-Sung Kim, Bosung Kim, Sung-Jin Bae, Y. Chae, D. Ryu, Ki-Tae Ha +7 moresemanticscholar +1 more source
