Results 21 to 30 of about 125,259 (249)
, 2017 Formation of the death-inducing signaling complex (DISC) initiates extrinsic apoptosis. Caspase-8 and its regulator cFLIP control death signaling by binding to death-receptor-bound FADD.
M Ploesser (7788878) +9 more
core +6 more sources
Molecules, 2018 A series of novel coumarin/2-cyanoacryloyl hybrids were prepared and evaluated for their in vitro anticancer activity. Among them, two analogs 5p and 5q showed promising antiproliferative activity against a panel of cancer cell lines, including A549 ...
Yu-Ying Zhang +5 more
doaj +1 more source
Pyroptosis: shedding light on the mechanisms and links with cancers
Frontiers in Immunology, 2023 Pyroptosis, a novel form of programmed cell death (PCD) discovered after apoptosis and necrosis, is characterized by cell swelling, cytomembrane perforation and lysis, chromatin DNA fragmentation, and the release of intracellular proinflammatory contents,
Hong-mei You +5 more
doaj +1 more source
Journal of Neuroscience Research, 2002 AbstractThe basic mechanisms that underlie neurodegenerative diseases are unknown. Loss of function of specific regions of the brain is due to incapacitation of cells that constitute those regions. Cells can simply stop functioning normally (neurons may cease to transmit signals), or they may die.
Carol M, Troy, Guy S, Salvesen
openaire +2 more sources
Synthesis of Chalcones with Anticancer Activities
Molecules, 2012 Several chalcones were synthesized and their<em> in vitro </em>cytotoxicity against various human cell lines, including human breast adenocarcinoma cell line MCF-7, human lung adenocarcinoma cell line A549, human prostate cancer cell line PC3,
Syam Mohan +3 more
doaj +1 more source
, 2022 Western blot of pro- and cleaved caspase-3 [ratio to ß-actin]. Shown are representative blots separated by location of lung tissue sampling (contusion site, ipsilateral control, and contralateral control). Lung tissue samples were homogenized, separated,
Martin Sassen (14232410) +7 more
core +1 more source
Codeine-induced sperm DNA damage is mediated predominantly by oxidative stress rather than apoptosis
Redox Report, 2020 Background: Opioids have been implicated to induce infertility. Although codeine remains the most used opioid for recreational purpose, no study has documented its effect on sperm quality.
Ayodeji Folorunso Ajayi +1 more
doaj +1 more source
Pharmaceutical Biology, 2022 Context Although Dolichandrone serrulata (Wall. ex DC.) Seem (Bignoniaceae) flower (DSF) improves hyperglycaemia, testicular damage and sperm quality in type 2 diabetes mellitus (T2DM) animals, its effects on the seminal vesicles, secreting seminal ...
Tarinee Sawatpanich +4 more
doaj +1 more source
Caspases and their substrates [PDF]
Cell Death & Differentiation, 2017 Protease biology is intimately linked to the functional consequences of substrate cleavage events. Human caspases are a family of 12 fate-determining cysteine proteases that are best known for driving cell death, either apoptosis or pyroptosis. More recently, caspases have been shown to be involved in other cellular remodeling events as well including ...
Olivier Julien, James A Wells
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Frontiers in Immunology, 2023 Granzymes A and K are two highly homologous serine proteases expressed by mammalian cytotoxic T cells (CTL) and natural killer cells (NK). Granzyme A is the most abundant of the different granzymes (gzms) expressed by these two cell types.
Erdem Aybay +9 more
doaj +1 more source