Results 21 to 30 of about 628,785 (360)
Molecules, 2020 The global incidence of breast cancer has increased. However, there are many impediments to the development of safe and effective anticancer drugs. The aim of the present study was to evaluate the effect of aviculin isolated from Lespedeza cuneata (Dum ...
Dahae Lee +7 more
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Journal of Neuroscience Research, 2002 AbstractThe basic mechanisms that underlie neurodegenerative diseases are unknown. Loss of function of specific regions of the brain is due to incapacitation of cells that constitute those regions. Cells can simply stop functioning normally (neurons may cease to transmit signals), or they may die.
Carol M, Troy, Guy S, Salvesen
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Pyroptosis was suppressed in ZIKV-infected macrophages with pro-caspase-1 knockdown. [PDF]
, 2022 (A) Knockdown of pro-caspase-1 in THP-1 cells. Cell lysates were prepared from lentiviral vector-transduced THP-1 cell lines, expressing shRNA1, 2, or 3 targeting mRNA of pro-caspase-1, for western blot analyses with pro-caspase-1 antibody to examine the
Yufeng Yu (10308089) +5 more
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Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1 [PDF]
, 2011 IL-1b and IL-18 are proinflammatory cytokines that contribute to renal immune complex disease, but whether IL-1b and IL-18 are mediators of intrinsic glomerular inflammation is unknown.
Volker Vielhauer +47 more
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Caspases and their substrates [PDF]
Cell Death & Differentiation, 2017 Protease biology is intimately linked to the functional consequences of substrate cleavage events. Human caspases are a family of 12 fate-determining cysteine proteases that are best known for driving cell death, either apoptosis or pyroptosis. More recently, caspases have been shown to be involved in other cellular remodeling events as well including ...
Olivier Julien, James A Wells
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Cell Death & Differentiation, 2000 Caspases, a group of cysteine proteases, constitute the effector arm of the cell death machinery. There are seven caspases known in Drosophila, three of which contain long amino-terminal prodomains. Although, compared to mammalian caspases, much less is known about the biology of Drosophila caspases, many studies have shown that caspases are essential ...
S, Kumar, J, Doumanis
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The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer
Cell Death Discovery, 2020 Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic drugs. In recent years, studies have proved that pyroptosis can also shrink tumors and inhibit cells proliferation.
Mingxia Jiang +3 more
semanticscholar +1 more source
Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death [PDF]
, 2003 Caspase-directed apoptosis usually fragments cells, releasing nonfunctional, prothrombogenic, membrane-bound apoptotic bodies marked for rapid engulfment by macrophages.
Jones, David B. +9 more
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Oncogene, 2003 Caspases are a family of cysteine proteases that play important roles in regulating apoptosis. A decade of research has generated a wealth of information on the signal transduction pathways mediated by caspases, the distinct functions of individual caspases and the mechanisms by which caspases mediate apoptosis and a variety of physiological and ...
Degterev, Alexei +2 more
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Caspase mediated cytotoxicity of a yellow pigment produced by Exiguobacterium alkaliphilum on human cancer cell lines [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2020 Context: Investigation of microbial diversity for the identification of novel bioactive compounds or therapeutics is a more potential and incessant ongoing process for drug development research.
Bharath Gajaraj, Varalakshmi Nadumane
doaj