Results 11 to 20 of about 422,774 (309)

Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]

, 2013
We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Subedi, Kalpana, Jennifer C. Condon, Chandrashekara Kyathanahalli, Kalpana Subedi, Lydon, John P., Arvind Suresh, Kyathanahalli, Chandrashekara, Condon, Jennifer C., Jeyasuria, Pancharatnam, Pancharatnam Jeyasuria, Rashekara Kyathanahalli, Jennifer C Condon, Suresh, Arvind   +12 more
core   +1 more source

Defining Characteristics of Types I and II Apoptotic Cells in Response to TRAIL

Neoplasia: An International Journal for Oncology Research, 2002
Type I cells have been defined to be independent of mitochondria for the induction of Fas death receptormediated apoptosis, whereas Type II cells are mitochondria-dependent.
Nesrin Özören, Wafik S. El-Deiry
doaj   +1 more source

The Lipopolysaccharide-Sensing Caspase(s)-4/11 Are Activated in Cirrhosis and Are Causally Associated With Progression to Multi-Organ Injury

Frontiers in Cell and Developmental Biology, 2021
Background and AimsThe development of multi-organ injury in cirrhosis is associated with increased intestinal permeability, translocation of gut-derived bacterial products [e.g., lipopolysaccharide (LPS)] into the circulation, and increased non-apoptotic
Ugo Soffientini, Ugo Soffientini, Nigel Beaton, Sukriti Baweja, Emmanuel Weiss, Emmanuel Weiss, Chhagan Bihari, Abeba Habtesion, Vishal Patel, Vishal Patel, Vishal Patel, Valerie Paradis, Archana Sharma, Tu Vinh Luong, Andrew Hall, Aida Nadar, Shiv Sarin, Shilpa Chokshi, Roger Williams, Benedicte Py, Richard Moreau, Richard Moreau, Rajiv Jalan, Gautam Mehta, Gautam Mehta   +24 more
doaj   +1 more source

Caspases on the brain [PDF]

Journal of Neuroscience Research, 2002
AbstractThe basic mechanisms that underlie neurodegenerative diseases are unknown. Loss of function of specific regions of the brain is due to incapacitation of cells that constitute those regions. Cells can simply stop functioning normally (neurons may cease to transmit signals), or they may die.
Carol M, Troy, Guy S, Salvesen
openaire   +2 more sources

Aviculin Isolated from Lespedeza cuneata Induce Apoptosis in Breast Cancer Cells through Mitochondria-Mediated Caspase Activation Pathway

Molecules, 2020
The global incidence of breast cancer has increased. However, there are many impediments to the development of safe and effective anticancer drugs. The aim of the present study was to evaluate the effect of aviculin isolated from Lespedeza cuneata (Dum ...
Dahae Lee, Yong Hoon Lee, Kwang Ho Lee, Bum Soo Lee, Akida Alishir, Yoon-Joo Ko, Ki Sung Kang, Ki Hyun Kim   +7 more
doaj   +1 more source

Caspases and their substrates [PDF]

Cell Death & Differentiation, 2017
Protease biology is intimately linked to the functional consequences of substrate cleavage events. Human caspases are a family of 12 fate-determining cysteine proteases that are best known for driving cell death, either apoptosis or pyroptosis. More recently, caspases have been shown to be involved in other cellular remodeling events as well including ...
Olivier Julien, James A Wells
openaire   +2 more sources

The fly caspases [PDF]

Cell Death & Differentiation, 2000
Caspases, a group of cysteine proteases, constitute the effector arm of the cell death machinery. There are seven caspases known in Drosophila, three of which contain long amino-terminal prodomains. Although, compared to mammalian caspases, much less is known about the biology of Drosophila caspases, many studies have shown that caspases are essential ...
S, Kumar, J, Doumanis
openaire   +2 more sources

Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1 [PDF]

, 2011
IL-1b and IL-18 are proinflammatory cytokines that contribute to renal immune complex disease, but whether IL-1b and IL-18 are mediators of intrinsic glomerular inflammation is unknown.
Volker Vielhauer, Clemens D Cohen, Vielhauer, V, Lichtnekert Julia, Dan Muruve, Shrikant R. Mulay, Muruve, D, Ramanjaneyulu Allam, Maja T. Lindenmeyer, Lichtnekert, Julia, Hans-Joachim Anders, Lindenmeyer, M T, Cohen Clemens D., Kulkarni, Onkar P., Vielhauer, Volker, Muruve Dan, Kulkarni Onkar P., Maja T Lindenmeyer, Cohen, Clemens D., Ryu, Mi, Rupanagudi Khader Valli, Ryu Mi, Khader Valli Rupanagudi, Mulay Shrikant R., Ryu, M, Lindenmeyer, Maja T., Anders Hans-Joachim, Clemens D. Cohen, Cohen, C D, Onkar P Kulkarni, Shrikant R Mulay, Allam, R, Allam Ramanjaneyulu, Vielhauer Volker, Muruve, Dan, Rupanagudi, Khader Valli, Anders, Hans-Joachim, Mi Ryu, Lichtnekert, J, Mulay, Shrikant R., Allam, Ramanjaneyulu, Julia Lichtnekert, Lindenmeyer Maja T., Rupanagudi, K V, Mulay, S R, Kulkarni, O P, Anders, H J, Onkar P. Kulkarni   +47 more
core   +1 more source

Caspase-2S relative mRNA expression levels in neurological disease.

, 2022
(A) Caspase-2S mRNA expression levels trend lower in AD but not MCI compared to CN controls. Caspase-2S mRNA do not differ in LBD (B) or HD (C) compared to controls.
Ronald C. Petersen (9562700), Chris Hlynialuk (12511813), Benjamin Smith (216177), Kailee Leinonen-Wright (12511816), Karen Ashe (7055705), Lisa Kemper (13840174)   +5 more
core   +1 more source

A decade of caspases [PDF]

Oncogene, 2003
Caspases are a family of cysteine proteases that play important roles in regulating apoptosis. A decade of research has generated a wealth of information on the signal transduction pathways mediated by caspases, the distinct functions of individual caspases and the mechanisms by which caspases mediate apoptosis and a variety of physiological and ...
Degterev, Alexei, Boyce, Michael, Yuan, Junying   +2 more
openaire   +2 more sources