Results 11 to 20 of about 125,259 (249)
Caspase-9 cleavage: do you need it
, 2007 Caspase-9 which is activated by association with the Apaf-1 apoptosome complex cleaves and activates the downstream effector caspases-3 and -7, thereby executing the caspase-cascade and cell death programme.
Davina Twiddy (7582331) +1 more
core +6 more sources
Hydatid Cyst Killing Mechanism of Ziziphora tenuior by Inducing Apoptosis via Mitochondrial Intrinsic Pathway [PDF]
Research Journal of Pharmacognosy, 2020 Background and objectives: Ziziphora tenuior is considered as an appropriate protoscolicidal agent yet the mechanism of such effect is not known so far. The aim of this study was to evaluate the apoptotic effect of Z.
Mojtaba Shahnazi +7 more
doaj +1 more source
Biomedicines, 2022 Inflammation plays a vital role in regulating fibrotic processes. Beside their classical role in extracellular matrix synthesis and remodeling, fibroblasts act as immune sentinel cells participating in regulating immune responses.
Thanh-Diep Ly +8 more
doaj +1 more source
Caspase-2: the orphan caspase [PDF]
Cell Death & Differentiation, 2011 Despite an abundance of literature on the role of caspase-2 in apoptosis, there exists much controversy about this protease making it difficult to place caspase-2 correctly in the apoptotic cascade, and hence its role in apoptosis remains unclear. The identification of the PIDDosome as a signaling platform for caspase-2 activation prompted intense ...
L, Bouchier-Hayes, D R, Green
openaire +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 We synthesised a new series of sulphonamide-bearing quinazolinone derivatives 5-18 and evaluated their in vitro cytotoxicity in various cancer cell lines (A549, HepG-2, LoVo and MCF-7) and in normal human cells (HUVEC).
Ali S. Alqahtani +5 more
doaj +1 more source
FEBS Open Bio, 2023 Proper regulation of apoptotic cell death is crucial for normal development and homeostasis in multicellular organisms and is achieved by the balance between pro‐apoptotic processes, such as caspase activation, and pro‐survival signaling, such as ...
Hisashi Moriizumi +4 more
doaj +1 more source
Application of Regulatory Cell Death in Cancer: Based on Targeted Therapy and Immunotherapy
Frontiers in Immunology, 2022 The development of cancer treatment methods is constantly changing. For common cancers, our treatment methods are still based on conventional treatment methods, such as chemotherapy, radiotherapy, and targeted drug therapy. Nevertheless, the emergence of
Xiaochen Qi +4 more
doaj +1 more source
Antiparasitic activity of Astragalus brachycalyx subsp. brachycalyx extract against hydatid cyst protoscoleces and its effect on induction of apoptosis: an in vitro and ex vivo study [PDF]
Journal of HerbMed Pharmacology, 2022 Introduction: This study aims to evaluate in vitro and ex vivo antiparasitic activity of Astragalus brachycalyx subsp. brachycalyx. root chloroformic extract against hydatid cyst protoscoleces and its effect on induction of apoptosis.
Javad Ghasemian Yadegari +3 more
doaj +1 more source
Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]
, 2014 The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity are typical features of neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. An unexpected role of caspase-
Rodhe, J +11 more
core +1 more source
Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]
, 2013 We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Subedi, Kalpana +12 more
core +2 more sources