Results 11 to 20 of about 578,436 (295)

Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]

, 2013
We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Condon, Jennifer C., Jeyasuria, Pancharatnam, Kyathanahalli, Chandrashekara, Lydon, John P., Subedi, Kalpana, Suresh, Arvind   +5 more
core   +27 more sources

Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death [PDF]

, 2016
Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β.
Alix, E, Birrell, M, Holden, D, Jennings, E, Matthews, S, Shao, F, Shenoy, A, Thurston, T   +7 more
core   +1 more source

A non-apoptotic role for caspase-9 in muscle differentiation [PDF]

, 2008
Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation.
Fearnhead, Howard O, Howley, Breege A, McMahon, Jill M, Mohr, Andrea, Murray, Thomas VA, Ritter, Thomas, Stanley, Alanna, Zwacka, Ralf   +7 more
core   +1 more source

Defining Characteristics of Types I and II Apoptotic Cells in Response to TRAIL

Neoplasia: An International Journal for Oncology Research, 2002
Type I cells have been defined to be independent of mitochondria for the induction of Fas death receptormediated apoptosis, whereas Type II cells are mitochondria-dependent.
Nesrin Özören, Wafik S. El-Deiry
doaj   +1 more source

The Lipopolysaccharide-Sensing Caspase(s)-4/11 Are Activated in Cirrhosis and Are Causally Associated With Progression to Multi-Organ Injury

Frontiers in Cell and Developmental Biology, 2021
Background and AimsThe development of multi-organ injury in cirrhosis is associated with increased intestinal permeability, translocation of gut-derived bacterial products [e.g., lipopolysaccharide (LPS)] into the circulation, and increased non-apoptotic
Ugo Soffientini, Ugo Soffientini, Nigel Beaton, Sukriti Baweja, Emmanuel Weiss, Emmanuel Weiss, Chhagan Bihari, Abeba Habtesion, Vishal Patel, Vishal Patel, Vishal Patel, Valerie Paradis, Archana Sharma, Tu Vinh Luong, Andrew Hall, Aida Nadar, Shiv Sarin, Shilpa Chokshi, Roger Williams, Benedicte Py, Richard Moreau, Richard Moreau, Rajiv Jalan, Gautam Mehta, Gautam Mehta   +24 more
doaj   +1 more source

A mutation in caspase-9 decreases the expression of BAFFR and ICOS in patients with immunodeficiency and lymphoproliferation [PDF]

, 2015
Lymphocyte apoptosis is mainly induced by either death receptor-dependent activation of caspase-8 or mitochondria-dependent activation of caspase-9. Mutations in caspase-8 lead to autoimmunity/lymphoproliferation and immunodeficiency. This work describes
Boggio, E, Cappellano, G, Chiocchetti, A., Clemente, N, Dianzani, C, Dianzani, I, Dianzani, U, Gigliotti, Cl, Notarangelo, Ld, Orilieri, E, Pignata, C, Quinti, Isabella, Ramenghi, U, Santoro, C, Toth, E, Valletti, Pa   +15 more
core   +2 more sources

Impact of L-carnitine and selenium treatment on testicular apoptosis in rats exposed to 2.45 GHz microwave energy [PDF]

, 2015
Objective: It has been suggested that electromagnetic radiation (EMR) by wireless devices (2.45 GHz) induces testicular apoptosis. We investigated if supplemental selenium (Se) and L-carnitine may reduce this adverse effect.
Comlekci, S., Gumral, N., Karahan, N., Ozguner, M.F., Saygin, M., Çalişkan, Sadettin   +5 more
core   +1 more source

Aviculin Isolated from Lespedeza cuneata Induce Apoptosis in Breast Cancer Cells through Mitochondria-Mediated Caspase Activation Pathway

Molecules, 2020
The global incidence of breast cancer has increased. However, there are many impediments to the development of safe and effective anticancer drugs. The aim of the present study was to evaluate the effect of aviculin isolated from Lespedeza cuneata (Dum ...
Dahae Lee, Yong Hoon Lee, Kwang Ho Lee, Bum Soo Lee, Akida Alishir, Yoon-Joo Ko, Ki Sung Kang, Ki Hyun Kim   +7 more
doaj   +1 more source

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]

, 2014
Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence.
A Castano, AM Verhagen, B Joseph, B Joseph, BP Eckelman, C Du, D Conte, DW Nicholson, E Varfolomeev, H Durkop, H Huang, JE Vince, JL Venero, K Rajalingam, K Saijo, K Saijo, M D'Amelio, M Gyrd-Hansen, M Luo, MA Burguillos, ML Block, N Muller-Sienerth, OH Voss, PL McGeer, S Kamada, SP Burke, ST Beug, T Tenev, V Bocchini, X Cui, Z Han   +30 more
core   +3 more sources

Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. [PDF]

, 2009
The aim of this study was to determine whether heat-shock pretreatment exerted a protective effect against sorbitol-induced apoptotic cell death in K562, U937 and HeLa cell lines and whether such protection was associated with a decreased cytochrome c
Aventaggiato, Michele, De Martino, Luisa, Di Stefano, Carla, Fiorito, Filomena, Indelicato, Manuela, Marfe, Gabriella, Pucci, Bruna, Russo, Matteo A., Tafani, Marco   +8 more
core   +1 more source