Current Strategies for Real-Time Enzyme Activation [PDF]
Biomolecules, 2022 Enzyme activation is a powerful means of achieving biotransformation function, aiming to intensify the reaction processes with a higher yield of product in a short time, and can be exploited for diverse applications.
Fang Wang, Yuchen Liu, Chang Du
exaly +3 more sources
Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems. [PDF]
Nat Commun, 2020 Protein-responsive soft materials capable of the controlled release of drugs and proteins are promising for use in next-generation diagnosis methods and therapies.
Shigemitsu H +7 more
europepmc +2 more sources
Enzyme activities in activated sludge flocs [PDF]
Applied Microbiology and Biotechnology, 2007 This study quantified the activities of enzymes in extracellular polymeric substances (EPS) and in pellets. Seven commonly adopted extraction schemes were utilized to extract from aerobic flocs the contained EPS, which were further categorized into loosely bound (LB) and tightly bound (TB) fractions.
Yu, Guang-Hui +3 more
openaire +2 more sources
The Role of Cytokines in Activation of Coagulation and Fibrinolysis in Dengue Shock Syndrome [PDF]
, 2002 In a prospective clinical study of 50 patients with Dengue Shock Syndrome (DSS), we investigated the association of tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-1 receptor antagonist (IL-1Ra), and IL-6 with activation markers of coagulation
Dolmans, Wil M.V. +31 more
core +1 more source
Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2and cell proliferationviaGαq-mediated mechanism [PDF]
, 2014 Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Cai, X +9 more
core +1 more source
Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]
, 2010 Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Schmid, Ralf +9 more
core +1 more source
Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 [PDF]
, 2009 Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart.
Smith, Godfrey +12 more
core +1 more source
, 2014 Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type enzyme and the nine most frequently ...
Lee, Christian +4 more
core +1 more source
Enzyme activity and flexibility at very low hydration
, 2005 Recent measurements have demonstrated enzyme activity at hydrations as low as 3%. This raises the question of whether hydration-induced enzyme flexibility is important for activity. Here, to address this, picosecond dynamic neutron scattering experiments
Kurkal, V. +9 more
core +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley +1 more source