Results 31 to 40 of about 3,488,746 (297)
Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19
Journal of Innate Immunity, 2022 Mannose-binding lectin-associated serine protease 2 (MASP-2) is the main activator of the lectin complement pathway and has been suggested to be involved in the pathophysiology of coronavirus disease 2019 (COVID-19).
Maximilian Peter Götz +8 more
doaj +1 more source
Unraveling the activation mechanism of the potato tuber ADP-glucose pyrophosphorylase. [PDF]
PLoS ONE, 2013 ADP-glucose pyrophosphorylase regulates the synthesis of glycogen in bacteria and of starch in plants. The enzyme from plants is mainly activated by 3-phosphoglycerate and is a heterotetramer comprising two small and two large subunits.
Carlos M Figueroa +6 more
doaj +1 more source
An Extended Polyanion Activation Surface in Insulin Degrading Enzyme.
PLoS ONE, 2015 Insulin degrading enzyme (IDE) is believed to be the major enzyme that metabolizes insulin and has been implicated in the degradation of a number of other bioactive peptides, including amyloid beta peptide (Aβ), glucagon, amylin, and atrial natriuretic ...
Eun Suk Song +9 more
doaj +1 more source
Graphical representation of YqfB/D8_RL enzyme-mediated activation of an anticancer prodrug.
, 2023 Graphical representation of YqfB/D8_RL enzyme-mediated activation of an anticancer prodrug.
Gediminas Plakys (17508986) +6 more
core +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng +3 more
wiley +1 more source
Covalently bound substrate at the regulatory site triggers allosteric enzyme activation [PDF]
, 2008 The mechanism by which the enzyme pyruvate decarboxylase from yeast is activated allosterically has been elucidated. A total of seven three-dimensional structures of the enzyme, of enzyme variants or of enzyme complexes form two yeast species (three of ...
Steffen Kutter +11 more
core
Activation Energy of Enzyme and Non-Enzyme Catalyzed Reactions
, 2023 The goal of this research was to compare the activation energy and rate constants of an enzyme catalyzed and a non-enzyme catalyzed hydrolysis reaction at different temperatures.
Moseley, Marie +3 more
core
Size‐Dependent Ultrasound Activation of Thrombin Catalytic Activity by Mechano‐Nanoswitches
Advanced ScienceIntegrating nanostructures with mechanochemistry significantly boosts drug loading capabilities and sonomechanical drug activation, outperforming traditional polymer systems.
Menghan Xiao +9 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Enzyme-Instructed Activation of Pro-protein Therapeutics In Vivo
, 2019 The selective and temporal control of protein activity in living cells provides a powerful tool to manipulate cellular function and to develop pro-protein therapeutics (PPT) for targeted therapy.
Qiao Tang (281623) +7 more
core +1 more source