Results 31 to 40 of about 3,285,804 (293)
Enzyme activity and flexibility at very low hydration [PDF]
, 2005 Recent measurements have demonstrated enzyme activity at hydrations as low as 3%. This raises the question of whether hydration-induced enzyme flexibility is important for activity. Here, to address this, picosecond dynamic neutron scattering experiments
Kurkal, V. +9 more
core +1 more source
The structural basis of the multi-step allosteric activation of Aurora B kinase
eLife, 2023 Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is not ...
Dario Segura-Peña +8 more
doaj +1 more source
Quantitative and evolutionary global analysis of enzyme reaction mechanisms [PDF]
, 2015 The most widely used classification system describing enzyme-catalysed reactions is the Enzyme Commission (EC) number. Understanding enzyme function is important for both fundamental scientific and pharmaceutical reasons.
Nath, Neetika
core +2 more sources
mBio, 2019 Carboxyl (C)-terminal processing proteases (CTPs) participate in protective and regulatory proteolysis in bacteria. The PDZ domain is central to the activity of CTPs but plays inherently different regulatory roles.
Chuang-Kai Chueh +5 more
doaj +1 more source
Enzyme activities in activated sludge flocs [PDF]
Applied Microbiology and Biotechnology, 2007 This study quantified the activities of enzymes in extracellular polymeric substances (EPS) and in pellets. Seven commonly adopted extraction schemes were utilized to extract from aerobic flocs the contained EPS, which were further categorized into loosely bound (LB) and tightly bound (TB) fractions.
Yu, Guang-Hui +3 more
openaire +2 more sources
Enzyme-mediated hydrolytic activation of prodrugs
Acta Pharmaceutica Sinica B, 2011 Prodrug design is an important part of drug discovery. Prodrugs can offer many advantages over parent drugs such as increased solubility, enhanced stability, improved bioavailability, reduced side effects, and better selectivity.
Yan-hui Yang +4 more
doaj +1 more source
In vivo activation of methyl-coenzyme M reductase by carbon monoxide
Frontiers in Microbiology, 2013 Methyl-coenzyme M reductase (MCR) from methanogenic archaea catalyzes the rate-limiting and final step in methane biosynthesis. Using coenzyme B (CoBSH) as the two-electron donor, MCR reduces methyl-coenzyme M (CH3-SCoM) to methane and the mixed ...
Yuzhen eZhou +2 more
doaj +1 more source
Cold-Water Immersion Promotes Antioxidant Enzyme Activation in Elite Taekwondo Athletes
Applied Sciences, 2021 The aim of this study was to investigate the effect of cold-water immersion (CWI) on lipid peroxides and antioxidant enzymes in adult Taekwondo athletes after a match. A cross-sectional study was performed.
Eun-Hee Park +2 more
doaj +1 more source
Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2and cell proliferationviaGαq-mediated mechanism [PDF]
, 2014 Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Cai, X +9 more
core +1 more source
Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia
Química Nova, 2006 Strategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with ...
Lorena Blau +2 more
doaj +1 more source