Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 [PDF]
, 2009 Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart.
Smith, Godfrey +12 more
core +1 more source
Activation Energy of Enzyme and Non-Enzyme Catalyzed Reactions [PDF]
, 2023 The goal of this research was to compare the activation energy and rate constants of an enzyme catalyzed and a non-enzyme catalyzed hydrolysis reaction at different temperatures.
Moseley, Marie +3 more
core
Enzyme activity below the dynamical transition at 220 K [PDF]
, 1998 Enzyme activity requires the activation of anharmonic motions, such as jumps between potential energy wells. However, in general, the forms and time scales of the functionally important anharmonic dynamics coupled to motion along the reaction coordinate ...
Smith, Jeremy C. +6 more
core +1 more source
Unraveling the activation mechanism of the potato tuber ADP-glucose pyrophosphorylase. [PDF]
PLoS ONE, 2013 ADP-glucose pyrophosphorylase regulates the synthesis of glycogen in bacteria and of starch in plants. The enzyme from plants is mainly activated by 3-phosphoglycerate and is a heterotetramer comprising two small and two large subunits.
Carlos M Figueroa +6 more
doaj +1 more source
Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19
Journal of Innate Immunity, 2022 Mannose-binding lectin-associated serine protease 2 (MASP-2) is the main activator of the lectin complement pathway and has been suggested to be involved in the pathophysiology of coronavirus disease 2019 (COVID-19).
Maximilian Peter Götz +8 more
doaj +1 more source
An Extended Polyanion Activation Surface in Insulin Degrading Enzyme.
PLoS ONE, 2015 Insulin degrading enzyme (IDE) is believed to be the major enzyme that metabolizes insulin and has been implicated in the degradation of a number of other bioactive peptides, including amyloid beta peptide (Aβ), glucagon, amylin, and atrial natriuretic ...
Eun Suk Song +9 more
doaj +1 more source
A comparative study of enzyme immobilization strategies for multi-walled carbon nanotube glucose biosensors [PDF]
, 2011 This work addresses the comparison of different strategies for improving biosensor performance using nanomaterials. Glucose biosensors based on commonly applied enzyme immobilization approaches, including sol-gel encapsulation approaches and ...
Claussen, Jonathan C. +17 more
core +2 more sources
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Covalently bound substrate at the regulatory site triggers allosteric enzyme activation [PDF]
, 2008 The mechanism by which the enzyme pyruvate decarboxylase from yeast is activated allosterically has been elucidated. A total of seven three-dimensional structures of the enzyme, of enzyme variants or of enzyme complexes form two yeast species (three of ...
Steffen Kutter +11 more
core +1 more source
Nitric oxide-induced activation of the AMP-activated protein kinase alpha2 subunit attenuates IKappaB kinase activity and inflammatory responses in endothelial cells [PDF]
, 2011 Background: In endothelial cells, activation of the AMP-activated protein kinase (AMPK) has been linked with anti-inflammatory actions but the events downstream of kinase activation are not well understood.
Timo Frömel +11 more
core +1 more source