Results 11 to 20 of about 3,488,746 (297)
Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia [PDF]
Química Nova, 2006 Strategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with ...
Lorena Blau +2 more
doaj +2 more sources
Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems. [PDF]
Nat Commun, 2020 Protein-responsive soft materials capable of the controlled release of drugs and proteins are promising for use in next-generation diagnosis methods and therapies.
Shigemitsu H +7 more
europepmc +4 more sources
A perspective on the discovery of enzyme activators
SLAS Discovery, 2022 Enzyme activation remains a largely under-represented and poorly exploited area of drug discovery despite some key literature examples of the successful application of enzyme activators by various mechanisms and their importance in a wide range of ...
Antonia Turberville +4 more
doaj +1 more source
Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation
Frontiers in Immunology, 2019 5-lipoxygenase (5-LOX) is a non-heme iron-containing dioxygenase expressed in immune cells that catalyzes the two initial steps in the biosynthesis of leukotrienes.
Beatrice Dufrusine +13 more
doaj +1 more source
Role of SUMO-1 modification in transcriptional activation [PDF]
, 2012 In unstimulated cells, the transcription factor NF-κB is held in the cytoplasm in an inactive state by IκB inhibitor proteins. Activation of NF--KB is mediated by signal induced degradation of IκBα via the ubiquitin proteasome-dependent pathway ...
Pinto Desterro, Maria Joana
core +2 more sources
Scientific Reports, 2023 The assembly state of enzymes is gaining interest as a mechanism for regulating the function of enzymes in living cells. One of the current topics in enzymology is the relationship between enzyme activity and the assembly state due to liquid–liquid phase
Tomoto Ura +7 more
doaj +1 more source
How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase? [PDF]
, 2014 Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type enzyme and the nine most frequently ...
Lee, Christian +4 more
core +1 more source
Activation of oxidoreductases by the formation of enzyme assembly
Scientific Reports, 2023 Biological properties of protein molecules depend on their interaction with other molecules, and enzymes are no exception. Enzyme activities are controlled by their interaction with other molecules in living cells.
Tomoto Ura +6 more
doaj +1 more source
Scanning Electron Microscopic Study of the Tongue Papillae Formation
Central Asian Journal of Medical Sciences, 2017 Objectives: To clarify the morphology of the tongue papillae formation and the metabolic characteristics along the papillae distribution in rats. Methods: The experiment was designed as a cross-sectional study and included; a scanning electron and light ...
Shine-Od Dalkhsuren +2 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2021 AMP-activated protein kinase (AMPK) is a key energy sensor regulating the cell metabolism in response to energy supply and demand. The evolutionary adaptation of AMPK to different tissues is accomplished through the expression of distinct isoforms that ...
Elnaz Aledavood +3 more
doaj +1 more source