Results 21 to 30 of about 1,615,580 (309)

PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology [PDF]

, 2018
The fibrinolysis proteinase tissue-type plasminogen activator (tPA, also known as PLAT) triggers cell signaling and regulates cell physiology. In PC12 cells, Schwann cells and macrophages, the N-methyl-D-aspartate receptor (NMDA-R) mediates tPA signaling.
Azmoon, Pardis, Banki, Michael A, Campana, Wendy M, Gilder, Andrew S, Gonias, Steven L, Mantuano, Elisabetta   +5 more
core   +2 more sources

The structural basis of the multi-step allosteric activation of Aurora B kinase

eLife, 2023
Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is not ...
Dario Segura-Peña, Oda Hovet, Hemanga Gogoi, Jennine Dawicki-McKenna, Stine Malene Hansen Wøien, Manuel Carrer, Ben E Black, Michele Cascella, Nikolina Sekulic   +8 more
doaj   +1 more source

Information transfer in signaling pathways : a study using coupled simulated and experimental data [PDF]

, 2008
Background: The topology of signaling cascades has been studied in quite some detail. However, how information is processed exactly is still relatively unknown.
Pahle, Jürgen, Green, Anne K., Dixon, C. Jane, Kummer, U. (Ursula)   +3 more
core   +5 more sources

Structural basis of the selective activation of enzyme isoforms: Allosteric response to activators of β1- and β2-containing AMPK complexes

Computational and Structural Biotechnology Journal, 2021
AMP-activated protein kinase (AMPK) is a key energy sensor regulating the cell metabolism in response to energy supply and demand. The evolutionary adaptation of AMPK to different tissues is accomplished through the expression of distinct isoforms that ...
Elnaz Aledavood, Alessia Forte, Carolina Estarellas, F. Javier Luque   +3 more
doaj   +1 more source

Approximations and their consequences for dynamic modelling of signal transduction pathways [PDF]

, 2007
Signal transduction is the process by which the cell converts one kind of signal or stimulus into another. This involves a sequence of biochemical reactions, carried out by proteins.
Asthagiri, Atkins, Blüthgen, Briggs, Brightmann, Chen, Cho, Cornish-Bowden, Crampin, De Jong, Downward, Eissing, Eric Bullinger, Fell, Ferrell, Ferrell, Ferrell, Fowler, Goldbeter, Goldbeter, Hatakeyama, Heinrich, Heinrich, Huang, Johann Rohwer, Kholodenko, Kholodenko, Laurent, Lewis, Llórens, Markevich, Mathews, Michaelis, Novak, Olaf Wolkenhauer, Rubinow, Schilling, Schnell, Schoeberl, Segel, Swameye, Thomas Millat, Timmer, Tyson, Tzafriri, Winfree, Wolkenhauer, Wolkenhauer, Wolkenhauer, Yeung   +49 more
core   +1 more source

enzyme activator [PDF]

, 2019
Citation: 'enzyme activator' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.E02153 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +2 more sources

Structural Basis for the Differential Regulatory Roles of the PDZ Domain in C-Terminal Processing Proteases

mBio, 2019
Carboxyl (C)-terminal processing proteases (CTPs) participate in protective and regulatory proteolysis in bacteria. The PDZ domain is central to the activity of CTPs but plays inherently different regulatory roles.
Chuang-Kai Chueh, Nilanjan Som, Lu-Chu Ke, Meng-Ru Ho, Manjula Reddy, Chung-I Chang   +5 more
doaj   +1 more source

Adipokinetic hormone enhances laminarin and bacterial lipopolysaccharide-induced activation of the prophenoloxidase cascade in the African migratory locust, Locusta migratoria [PDF]

, 2002
Lom-AKH-I enhances the activation in vivo of prophenoloxidase in the haemolymph of the African migratory locust, Locusta migratoria, in response to challenge with laminarin.
Brehelin, Coodin, Dettloff, Dunphy, Duvic, Gillespie, Goldsworthy, Goldsworthy, Goldsworthy, Graham Goldsworthy, Gunnarsson, Gunnarsson, Halwani, Halwani, Hoffmann, Kato, Kato, Kitchens, Kwaku Opoku-Ware, Lisa Mullen, Mandato, Ratcliffe, Wiesner, Zor   +23 more
core   +1 more source

Expression and modulation of an NADPH oxidase in mammalian astrocytes [PDF]

, 2005
Amyloid β peptides generate oxidative stress in hippocampal astrocytes through a mechanism sensitive to inhibitors of the NADPH oxidase [diphenylene iodonium (DPI) and apocynin].
Abramov, A.Y., Canevari, L., Duchen, M.R., Hothersall, J., Jacobson, J., Wientjes, F.   +5 more
core   +1 more source

Enzyme-mediated hydrolytic activation of prodrugs

Acta Pharmaceutica Sinica B, 2011
Prodrug design is an important part of drug discovery. Prodrugs can offer many advantages over parent drugs such as increased solubility, enhanced stability, improved bioavailability, reduced side effects, and better selectivity.
Yan-hui Yang, Herve Aloysius, Daigo Inoyama, Yu Chen, Long-qin Hu   +4 more
doaj   +1 more source