Results 21 to 30 of about 1,097,067 (307)

The Role of Cytokines in Activation of Coagulation and Fibrinolysis in Dengue Shock Syndrome [PDF]

, 2002
In a prospective clinical study of 50 patients with Dengue Shock Syndrome (DSS), we investigated the association of tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-1 receptor antagonist (IL-1Ra), and IL-6 with activation markers of coagulation
Dolmans, Wil M.V., van der Meer, Jos W. M., Wil Dolmans, Setiati, T.E., Dolmans, W.M.V., C. Hack, Jos van der Meer, Hugo ten Cate, Hack, C. Erik, Hack, C.E., Djokomoeljanto, R.J., Cate, H. ten, Djokomoeljanto, Robert J., Cate, Hugo ten, Suharti, C., Catharina Suharti, Djokomoeljanto, Robert J., Gorp, E. van, Meer, J.W.M. van der, Dolmans, Wil M. V., Setiati, Tatty E., Meer, Jos W.M. van der, Eric van Gorp, Napel, C.H.H. ten, Gorp , Eric C.M. van, ten, Cate Hugo, Suharti, Catharina, Setiati , Tatty E., Robert Djokomoeljanto, Gorp, E.C.M. van, van Gorp, Eric C. M., Tatty Setiati   +31 more
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Structural basis of the selective activation of enzyme isoforms: Allosteric response to activators of β1- and β2-containing AMPK complexes

Computational and Structural Biotechnology Journal, 2021
AMP-activated protein kinase (AMPK) is a key energy sensor regulating the cell metabolism in response to energy supply and demand. The evolutionary adaptation of AMPK to different tissues is accomplished through the expression of distinct isoforms that ...
Elnaz Aledavood, Alessia Forte, Carolina Estarellas, F. Javier Luque   +3 more
doaj   +1 more source

The structural basis of the multi-step allosteric activation of Aurora B kinase

eLife, 2023
Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is not ...
Dario Segura-Peña, Oda Hovet, Hemanga Gogoi, Jennine Dawicki-McKenna, Stine Malene Hansen Wøien, Manuel Carrer, Ben E Black, Michele Cascella, Nikolina Sekulic   +8 more
doaj   +1 more source

Enzyme-Instructed Activation of Pro-protein Therapeutics In Vivo [PDF]

, 2019
The selective and temporal control of protein activity in living cells provides a powerful tool to manipulate cellular function and to develop pro-protein therapeutics (PPT) for targeted therapy.
Qiao Tang (281623), Ming Wang (172316), Lanqun Mao (1430338), Weiqi Cai (7513556), Ying Jiang (5910), Jin Chang (1372593), Chunjing Liang (7513559), Xianghan Chen (7513562)   +7 more
core   +1 more source

Structural Basis for the Differential Regulatory Roles of the PDZ Domain in C-Terminal Processing Proteases

mBio, 2019
Carboxyl (C)-terminal processing proteases (CTPs) participate in protective and regulatory proteolysis in bacteria. The PDZ domain is central to the activity of CTPs but plays inherently different regulatory roles.
Chuang-Kai Chueh, Nilanjan Som, Lu-Chu Ke, Meng-Ru Ho, Manjula Reddy, Chung-I Chang   +5 more
doaj   +1 more source

Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2and cell proliferationviaGαq-mediated mechanism [PDF]

, 2014
Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Cai, X, Jiang, Y, Karteris, E, Bai, B, Chen, J, Karteris, Emmanouil, Bai, Bo, Jiang, Yunlu, Cai, Xin, Chen, Jing   +9 more
core   +1 more source

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Schmid, Ralf, Schwaeble, Wilhelm J., Wilhelm J. Schwaeble, Anthony H. Keeble, Russell Wallis, Mitchell, Daniel A., Keeble, Anthony H., Wallis, Russell, Ralf Schmid, Daniel A. Mitchell   +9 more
core   +1 more source

Enzyme-mediated hydrolytic activation of prodrugs

Acta Pharmaceutica Sinica B, 2011
Prodrug design is an important part of drug discovery. Prodrugs can offer many advantages over parent drugs such as increased solubility, enhanced stability, improved bioavailability, reduced side effects, and better selectivity.
Yan-hui Yang, Herve Aloysius, Daigo Inoyama, Yu Chen, Long-qin Hu   +4 more
doaj   +1 more source

In vivo activation of methyl-coenzyme M reductase by carbon monoxide

Frontiers in Microbiology, 2013
Methyl-coenzyme M reductase (MCR) from methanogenic archaea catalyzes the rate-limiting and final step in methane biosynthesis. Using coenzyme B (CoBSH) as the two-electron donor, MCR reduces methyl-coenzyme M (CH3-SCoM) to methane and the mixed ...
Yuzhen eZhou, Alexandria E. Dorchak, Stephen Wiley Ragsdale   +2 more
doaj   +1 more source

Cold-Water Immersion Promotes Antioxidant Enzyme Activation in Elite Taekwondo Athletes

Applied Sciences, 2021
The aim of this study was to investigate the effect of cold-water immersion (CWI) on lipid peroxides and antioxidant enzymes in adult Taekwondo athletes after a match. A cross-sectional study was performed.
Eun-Hee Park, Seung-Wook Choi, Yoon-Kwon Yang   +2 more
doaj   +1 more source