Results 21 to 30 of about 3,285,804 (293)

A Novel Method of a High Pressure Processing Pre-Treatment on the Juice Yield and Quality of Persimmon

Foods, 2021
This study investigates the effects of a high pressure processing pre-treatment (pre-HPP) on the juice yield of persimmon (Diospyros kaki L.) pulp and the pre-HPP plus HPP or thermal processing (TP) on microorganism inactivation and quality changes of ...
Jiayue Xu, Yilun Wang, Xinyue Zhang, Zhen Zhao, Yao Yang, Xin Yang, Yongtao Wang, Xiaojun Liao, Liang Zhao   +8 more
doaj   +1 more source

Conditionally Activated (“Caged”) Oligonucleotides

Molecules, 2021
Conditionally activated (“caged”) oligonucleotides provide useful spatiotemporal control for studying dynamic biological processes, e.g., regulating in vivo gene expression or probing specific oligonucleotide targets.
Linlin Yang, Ivan J. Dmochowski
doaj   +1 more source

A perspective on the discovery of enzyme activators

SLAS Discovery, 2022
Enzyme activation remains a largely under-represented and poorly exploited area of drug discovery despite some key literature examples of the successful application of enzyme activators by various mechanisms and their importance in a wide range of ...
Antonia Turberville, Hannah Semple, Gareth Davies, Delyan Ivanov, Geoffrey A. Holdgate   +4 more
doaj   +1 more source

Role of SUMO-1 modification in transcriptional activation [PDF]

, 2012
In unstimulated cells, the transcription factor NF-κB is held in the cytoplasm in an inactive state by IκB inhibitor proteins. Activation of NF--KB is mediated by signal induced degradation of IκBα via the ubiquitin proteasome-dependent pathway ...
Pinto Desterro, Maria Joana
core   +2 more sources

Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation

Frontiers in Immunology, 2019
5-lipoxygenase (5-LOX) is a non-heme iron-containing dioxygenase expressed in immune cells that catalyzes the two initial steps in the biosynthesis of leukotrienes.
Beatrice Dufrusine, Andrea Di Francesco, Sergio Oddi, Sergio Oddi, Lucia Scipioni, Clotilde Beatrice Angelucci, Claudio D'Addario, Mauro Serafini, Ann-Kathrin Häfner, Dieter Steinhilber, Mauro Maccarrone, Mauro Maccarrone, Enrico Dainese, Enrico Dainese   +13 more
doaj   +1 more source

Activation of L-lactate oxidase by the formation of enzyme assemblies through liquid–liquid phase separation

Scientific Reports, 2023
The assembly state of enzymes is gaining interest as a mechanism for regulating the function of enzymes in living cells. One of the current topics in enzymology is the relationship between enzyme activity and the assembly state due to liquid–liquid phase
Tomoto Ura, Ako Kagawa, Nanako Sakakibara, Hiromasa Yagi, Naoya Tochio, Takanori Kigawa, Kentaro Shiraki, Tsutomu Mikawa   +7 more
doaj   +1 more source

The Role of Cytokines in Activation of Coagulation and Fibrinolysis in Dengue Shock Syndrome [PDF]

, 2002
In a prospective clinical study of 50 patients with Dengue Shock Syndrome (DSS), we investigated the association of tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-1 receptor antagonist (IL-1Ra), and IL-6 with activation markers of coagulation
Dolmans, Wil M.V., van der Meer, Jos W. M., Wil Dolmans, Setiati, T.E., Dolmans, W.M.V., C. Hack, Jos van der Meer, Hugo ten Cate, Hack, C. Erik, Hack, C.E., Djokomoeljanto, R.J., Cate, H. ten, Djokomoeljanto, Robert J., Cate, Hugo ten, Suharti, C., Catharina Suharti, Djokomoeljanto, Robert J., Gorp, E. van, Meer, J.W.M. van der, Dolmans, Wil M. V., Setiati, Tatty E., Meer, Jos W.M. van der, Eric van Gorp, Napel, C.H.H. ten, Gorp , Eric C.M. van, ten, Cate Hugo, Suharti, Catharina, Setiati , Tatty E., Robert Djokomoeljanto, Gorp, E.C.M. van, van Gorp, Eric C. M., Tatty Setiati   +31 more
core   +2 more sources

How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase? [PDF]

, 2014
Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type enzyme and the nine most frequently ...
Lee, Christian, Donev, Rossen, Christov, Christo, Black, Gary, Karabencheva-Christova, Tatyana   +4 more
core   +1 more source

Activation of oxidoreductases by the formation of enzyme assembly

Scientific Reports, 2023
Biological properties of protein molecules depend on their interaction with other molecules, and enzymes are no exception. Enzyme activities are controlled by their interaction with other molecules in living cells.
Tomoto Ura, Nanako Sakakibara, Yu Hirano, Taro Tamada, Yoichi Takakusagi, Kentaro Shiraki, Tsutomu Mikawa   +6 more
doaj   +1 more source

Scanning Electron Microscopic Study of the Tongue Papillae Formation

Central Asian Journal of Medical Sciences, 2017
Objectives: To clarify the morphology of the tongue papillae formation and the metabolic characteristics along the papillae distribution in rats. Methods: The experiment was designed as a cross-sectional study and included; a scanning electron and light ...
Shine-Od Dalkhsuren, Dolgorsuren Aldartsogt, Kikuji Yamashita   +2 more
doaj   +1 more source