Results 51 to 60 of about 628,785 (360)

Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells [PDF]

, 2012
For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner.
Gabor Barna (146087), Pal I Bauer, Istvan Petak, Mihalik, Rudolf, Zsuzsanna A Dunai, Gergely Imre, Istvan Petak (5648680), Pal I. Bauer (144904), Gergely Imre (146083), Imre, Gergely, Tamas Korcsmaros, Dunai, Zsuzsanna A., Barna, Gabor, Rudolf Mihalik, Bauer, Pal I., Gabor Barna, Rudolf Mihalik (146097), Petak, Istvan, Zsuzsanna A. Dunai (144901), Korcsmaros, Tamas, Tamas Korcsmaros (146091)   +20 more
core   +1 more source

Porcine Enteric Coronavirus PEDV Induces the ROS-ATM and Caspase7-CAD-γH2AX Signaling Pathways to Foster Its Replication

Viruses, 2022
DNA damage response (DDR) is an evolutionarily conserved mechanism by which eukaryotic cells sense DNA lesions caused by intrinsic and extrinsic stimuli, including virus infection.
Xin Ming, Huan Chen, Ying Yang, Pu Zhao, Liumei Sun, Caisheng Zhang, Hyun-Jin Shin, Jeong-Soo Lee, Yong-Sam Jung, Yingjuan Qian   +9 more
doaj   +1 more source

Caspase-8 is not activated by caspase-3. [PDF]

, 2017
(A) Microscopic images of cells expressing FRET-Bid in the absence or presence of Ac-DEVD-CHO (caspase-3 inhibitor, 20 μM) in Huh-7 and HepG2 cells.
Liping Wu (578606), Tongsheng Chen (394172), Gaina Xi (3330204), Yilin Pang (3330201), Guiqi Qin (3737875), Xiaoping Wang (110673), Shengnan Wu (2299912)   +6 more
core   +1 more source

Inflammasomes and idiopathic inflammatory myopathies

Frontiers in Immunology
Idiopathic inflammatory myopathies (IIM) are a group of systemic autoimmune diseases characterized by muscle weakness and elevated serum creatine kinase levels.
Rui Sun, Jiyan Chu, Jiyan Chu, Ping Li
doaj   +1 more source

The marine toxin, Yessotoxin, induces apoptosis and increases mitochondrial activity

Frontiers in Marine Science, 2014
: Yessotoxin (YTX) group are phycotoxins produced by different species of dinoflagellates. YTX activates the Phosphodiesterases (PDEs). This group of toxins can be consumed by humans, however no intoxication events are reported.
Andrea Fernandez-Araujo, M. Mercedes Rodríguez Vieytes, Ana María Botana   +2 more
doaj   +1 more source

Angiotensin II Receptor Blocker Irbesartan Enhanced SIRT1 longevity Signaling Replaces the Mitochondrial Biogenetic Survival Pathway to Attenuate Hypertension-Induced Heart Apoptosis

Journal of Cardiovascular Development and Disease, 2022
Background: The present study investigated whether angiotensin II type 1 receptor blocker irbesartan (ARB) and partial agonist of PPAR-γ prevents heart apoptosis by suppressing cardiac Fas/FasL-mediated to mitochondria-mediated apoptosis in the hearts of
Pei-Ying Pai, James K. S. Wong, Zhen-Yang Cui, Yi-Yuan Lin, Shin-Da Lee   +4 more
doaj   +1 more source

An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis

Science, 2020
Liver disease defect identified The energy sensor adenosine monophosphate–activated protein kinase (AMPK) is implicated in liver damage in nonalcoholic steatohepatitis (NASH), a leading cause of liver-associated death in humans. Zhao et al.
Peng Zhao, Xiaoli Sun, Cynthia Chaggan, Z. Liao, Kai in Wong, Feng He, Seema Singh, R. Loomba, M. Karin, J. Witztum, A. Saltiel   +10 more
semanticscholar   +1 more source

Caspase‐8: A key protein of cross‐talk signal way in “PANoptosis” in cancer

International Journal of Cancer, 2021
Cysteinyl aspartate specific proteinase (Caspase)‐8 has long been considered a promoter of apoptosis and part of the mechanism by which cytotoxic drugs kill cancer cells.
Mingxia Jiang, L. Qi, Lisha Li, Yiming Wu, D. Song, Yanjing Li   +5 more
semanticscholar   +1 more source

Caspase-8 and Caspase-9 Functioned Differently at Different Stages of the Cyclic Stretch-Induced Apoptosis in Human Periodontal Ligament Cells [PDF]

, 2016
BackgroundHuman periodontal ligament (PDL) cells underwent apoptosis after mechanical stretch loading. However, the exact signalling pathway remains unknown.
Chun Xu (286394), Fuqiang Zhang (404974), Dan Zhao (285025), Jiabao Zhuang (3394868), Yaqin Wu (275577)   +4 more
core   +1 more source

Propyl gallate induces human pulmonary fibroblast cell death through the regulation of Bax and caspase-3

Annals of Medicine
Propyl gallate (PG) has been found to exert an inhibitory effect on the growth of different cell types, including lung cancer cells. However, little is known about the cytotoxicological effects of PG specifically on normal primary lung cells. The current
Woo Hyun Park
doaj   +1 more source