Results 51 to 60 of about 125,259 (249)

Caspase-3/-6/-8 are required for Gsdme-dependent pyroptosis.

, 2022
a Images and cell viability of WT, Nlrp3-/-, Caspase-1-/- and Gsdmd-/- BMDMs left untreated or stimulated with ATP and silica. Arrowheads indicate pyroptotic cells. The scale bar represents 100 μm.
Yujie Zou (408340), Yaqiong Tian (6309854), Peiliang Shi (2617767), Lulu Kang (684986), Ji Zhang (70438), Visarut Codey Buranasudja (14209915), Jinghong Dai (13848544), Jingwen Pei (5626415), Xiang Gao (4077), Hourong Cai (6309875), Zhaoyu Lin (170763), Yufang Wang (105742), Jingyu Chen (3571688)   +12 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pseudoginsengenin DQ Exhibits Therapeutic Effects in Cisplatin-Induced Acute Kidney Injury via Sirt1/NF-κB and Caspase Signaling Pathway without Compromising Its Antitumor Activity in Mice

Molecules, 2018
In this study, the protective effects of pseudoginsengenin DQ (PDQ) on cisplatin (CDDP)-induced nephrotoxicity were assessed, with a primary investigation into the mechanisms involved.
Zeng Qi, Zhuo Li, Wei Li, Yunhe Liu, Cuizhu Wang, Hongqiang Lin, Jinping Liu, Pingya Li   +7 more
doaj   +1 more source

ANTP-SMACN7 fusion peptide alone induced high linear energy transfer irradiation radiosensitization in non-small cell lung cancer cell lines

Cancer Biology & Medicine, 2022
Objective: The aim of the present study was to investigate the mechanisms responsible for the radiation-sensitizing effect of antennapedia proteins, ANTP-SMACN7, on lung cancer cells treated with accelerated carbon and Fe particle irradiation.
Yi Xie, Bing Wang, Liqing Du, Yan Wang, Chang Xu, Hong Zhang, Kaixue Wen, Qiang Liu, Takanori Katsube   +8 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Hydrogen peroxide has adverse effects on human sperm quality parameters, induces apoptosis, and reduces survival

Journal of Human Reproductive Sciences, 2021
Background: One of the causes of male fertility disorders is the exposure of oxidative stress on the human sperm. Understanding the mechanism of disturbance is important to develop a better treatment for infertile or subfertile patients. Aims: The aim of
Dwi Ari Pujianto, Mona Oktarina, Ida Ayu Sharma Sharaswati, Yulhasri   +3 more
doaj   +1 more source

Caspase-Dependent and Caspase-Independent Pathways Are Involved in Cadmium-Induced Apoptosis in Primary Rat Proximal Tubular Cell Culture. [PDF]

, 2016
We designed this study to investigate whether cadmium induces caspase-independent apoptosis and to investigate the relationship between the caspase-dependent and caspase-independent apoptotic pathways.
Xuezhong Liu, Jiaqiao Zhu, Mengfei Long, Hui Zou, Yan Yuan (20767), Yan Yuan, Tongwang Luo (3353570), Jiaqiao Zhu (753911), Gang Liu (81776), Jianhong Gu (753909), Gang Liu, Yi Wang (32470), Zongping Liu, Ruilong Song (827410), Yi Wang, Xuezhong Liu (753908), Zongping Liu (827411), Jianchun Bian (753910), Jianhong Gu, Ruilong Song, Mengfei Long (3353567), Tongwang Luo, Jianchun Bian, Hui Zou (666389)   +23 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Anchoring of FRET Sensors—A Requirement for Spatiotemporal Resolution

Sensors, 2016
FRET biosensors have become a routine tool for investigating mechanisms and components of cell signaling. Strategies for improving them for particular applications are continuously sought.
Elena V. Ivanova, Ricardo A. Figueroa, Tom Gatsinzi, Einar Hallberg, Kerstin Iverfeldt   +4 more
doaj   +1 more source