Results 71 to 80 of about 628,785 (360)

Caspase-Mediated Cleavage of Human Cortactin during Influenza A Virus Infection Occurs in Its Actin-Binding Domains and Is Associated with Released Virus Titres

Viruses, 2020
Influenza A virus (IAV) exploits host factors to multiply and cause disease. An in-depth knowledge of this interaction of IAV with the host will aid the development of anti-IAV intervention strategies.
Da-Yuan Chen, Matloob Husain
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Caspase inhibitors affect the kinetics and dimensions of tracheary elements in xylogenic Zinnia (Zinnia elegans) cell cultures [PDF]

, 2010
Background The xylem vascular system is composed of fused dead, hollow cells called tracheary elements (TEs) that originate through trans-differentiation of root and shoot cambium cells. TEs undergo autolysis as they differentiate and mature.
Elena T Iakimova, Ernst J Woltering, Qian Tian, Twumasi, P., Schel Jan HN, Emons, A.M.C., Wim van Ieperen, Olaf van Kooten, van Ieperen Wim, van Kooten, O., van Ieperen, W., Iakimova, E.T., van Kooten Olaf, Qian, T., Emons Anne, Schel, J.H.N., Peter Twumasi, Tian Qian, Iakimova Elena T, Woltering, E.J., Anne Emons, Kooten, O., van, Ieperen, W., van, Anne MieC Emons, Twumasi Peter, Woltering Ernst J, Jan HN Schel   +26 more
core   +1 more source

Caspase-1 inhibition by YVAD generates tregs pivoting IL-17 to IL-22 response in β-glucan induced airway inflammation [PDF]

, 2022
During Aspergillus fumigatus mediated lung inflammation, NLRP3 inflammasome is rapidly activated that aggravates IL-1β production contributing to lung inflammation.
Parameswar Dalai (12159242), Divyesh Patel (5476793), Shivani Yadav (12159236), Dipeeka Mandaliya (12159233), Hima Vora (12159245), Omkar Naik (12159239), Dhruvi Shah (4951405), Naveen Challagundla (12159230), Reena Agrawal-Rajput (4951399)   +8 more
core   +1 more source

Caspase-1 initiates apoptosis in the absence of gasdermin D

Nature Communications, 2019
Caspase-1 activated in inflammasomes triggers a programmed necrosis called pyroptosis, which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells are still susceptible to caspase-1-mediated cell death.
K. Tsuchiya, S. Nakajima, S. Hosojima, Dinh Thi Nguyen, T. Hattori, Thuong Manh Le, O. Hori, M. Mahib, Y. Yamaguchi, M. Miura, T. Kinoshita, Hiroko Kushiyama, Mayumi Sakurai, T. Shiroishi, T. Suda   +14 more
semanticscholar   +1 more source

Guanylate-Binding Proteins (GBPs) convert cytosolic bacteria into caspase-4 signaling platforms

Nature Immunology, 2020
Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in the membranes of cytosol-invading bacteria activates caspases remains unknown. Here we
M. Wandel, B. Kim, Eui-Soon Park, Keith B Boyle, Komal M. Nayak, Brice Lagrange, Adrian Herod, T. Henry, M. Zilbauer, J. Rohde, J. MacMicking, F. Randow   +11 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Caspase-9 cleavage: do you need it [PDF]

, 2007
Caspase-9 which is activated by association with the Apaf-1 apoptosome complex cleaves and activates the downstream effector caspases-3 and -7, thereby executing the caspase-cascade and cell death programme.
Davina Twiddy (7582331), Kelvin Cain (1784650)   +1 more
core  

CAPE Analogs Induce Growth Arrest and Apoptosis in Breast Cancer Cells

Molecules, 2015
Breast cancer is the second leading cause of death amongst women worldwide. As a result, many have turned their attention to new alternative approaches to treat this disease.
Annie-Pier Beauregard, Jason Harquail, Grégoire Lassalle-Claux, Mehdi Belbraouet, Jacques Jean-Francois, Mohamed Touaibia, Gilles A. Robichaud   +6 more
doaj   +1 more source

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Here we demonstrate that Yersinia YopJ-induced murine macrophage death involves caspase-8–induced cleavage of both gasdermin D (GSDMD) and gasdermin E (GSDME).
Joseph Sarhan, Beiyun C. Liu, Hayley I. Muendlein, Peng Li, R. Nilson, Amy Y. Tang, A. Rongvaux, S. Bunnell, F. Shao, D. Green, A. Poltorak   +10 more
semanticscholar   +1 more source