Results 81 to 90 of about 628,785 (360)
International Journal of Biochemistry and Cell Biology, 2020 Caspase-9 is a member of caspase family of cysteine proteases that have been implicated in apoptosis and cytokine processing. When cells receive apoptotic stimuli, mitochondria releases cytochrome c which then binds to Apaf-1, the mammalian Ced-4 ...
K. Kuida
semanticscholar +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Caspase-8 is upstream of caspase-1 in the death pathway of Ripk1D325A/D325A mice at E10.5. [PDF]
, 2021 (A and B) IF staining of E10.5 YS with anti-PECAM (red) and anti-Cl.CASP1 (green) antibodies. Scale bars, 50 μm. Images are representative of 4 embryos per genotype.
Ye-hsuan Sun (11338002) +12 more
core +1 more source
Pharmaceutical Biology, 2022 Context Momordica charantia L. (Cucurbitaceae), known as bitter melon, is an edible fruit cultivated in the tropics. In this study, an active compound, 5β,19-epoxycucurbita-6,23(E)-diene-3β,19(R),25-triol (ECDT), isolated from M.
Mei-Kang Yuan +5 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Caspase-3/7 activity observed during KSHV infection when Bcl-xL is inhibited. [PDF]
, 2023 Representative images of mock or KSHV infected TIME cells that have been treated with vehicle control or A-133 at 48 hpi. A caspase-3/7 substrate was added to all cells at the same time as vehicle control or A-133.
Michael Lagunoff (143637) +9 more
core +1 more source
Frontiers in Neuroscience, 2015 Nanotechnology, a rapidly evolving field, provides simple and practical tools to investigate the nervous system in health and disease. Among these tools are nanoparticle-based probes and sensors that detect biochemical and physiological properties of ...
Dusica eMaysinger +3 more
doaj +1 more source
Insects, 2020 The aim of the current study was to delve into the causes of mortality of Spodoptera littoralis larvae feeding on Metarhizium-colonized plants in the absence of fungal outgrowth on the cadavers as previous studies reported and to elucidate the possible ...
Inmaculada Garrido-Jurado +3 more
doaj +1 more source
Pharmaceutical Biology, 2022 Context Due to the resistance of Helicobacter pylori to antibiotics, it is difficult to eradicate this pathogenic bacterium from the host. The role of 1α, 25-dihydroxyvitamin D3 (1,25-D3) in H.
Shuai Zhao +3 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source