Results 101 to 110 of about 422,774 (309)
Advanced Functional Materials, EarlyView.This study reports a microfluidic device with a functionalized surface utilizing a polyoxazoline coating and covalently immobilized gold nanoparticles and anti‐phosphatidylserine antibody. The device efficiently eliminates pre‐apoptotic and apoptotic spermatozoa and yields sperm with substantially improved quality and low DNA damage, offering a simple ...
Soraya Rasi Ghaemi +5 more
wiley +1 more source
Caspase-8 is upstream of caspase-1 in the death pathway of Ripk1D325A/D325A mice at E10.5.
, 2021 (A and B) IF staining of E10.5 YS with anti-PECAM (red) and anti-Cl.CASP1 (green) antibodies. Scale bars, 50 μm. Images are representative of 4 embryos per genotype.
Ye-hsuan Sun (11338002) +12 more
core +1 more source
Open ChemistryBreast cancer (BC) continues to be a primary worldwide health concern despite the tremendous efforts made to deploy novel chemotherapeutic techniques for the treatment of BC. It is, therefore, essential to elucidate better plant-based compounds targeting
Pandey Pratibha +6 more
doaj +1 more source
Mechanoluminescent HOF Nanotransducers Enabled Sono‐Optogenetics in Parkinsonian Rats
Advanced Functional Materials, EarlyView.We present a mechanoluminescent system utilizing porous hydrogen‐bonded organic frameworks (HOFs) as a toolkit for focused ultrasound‐triggered, non‐invasive light delivery to the deep brain in rats. This approach enables the specific activation of PV‐GPe neurons in dopamine‐depleted Parkinson's disease rat models, resulting in a comparable alleviation
Wenliang Wang +18 more
wiley +1 more source
Caspase-3/7 activity observed during KSHV infection when Bcl-xL is inhibited.
, 2023 Representative images of mock or KSHV infected TIME cells that have been treated with vehicle control or A-133 at 48 hpi. A caspase-3/7 substrate was added to all cells at the same time as vehicle control or A-133.
Michael Lagunoff (143637) +9 more
core +1 more source
Advanced Functional Materials, EarlyView.We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins +9 more
wiley +1 more source
Caspase-11 controls pyroptosis of lung epithelial cells.
, 2018 (A) TC-1 cells were infected with B. thailandensis or the bsaZ mutant in presence or absence of IFNγ. Active caspase-11 was pulled-down from cell lysates using Biotin-VAD-FMK and detected by immunoblot.
Fabio Re (189981) +6 more
core +1 more source
Caspase-1 activation during Eh-macrophage contact degrades cullin-1/5.
, 2021 (A, B) THP-1 derived macrophages were pre-incubated with the pan-caspase inhibitor Z-VAD-fmk (100μM) and caspase-1 specific inhibitor Z-YVAD-fmk (100μM) for 1 h followed by stimulation with Eh (10:1 ratio) for 10 min.
Kris Chadee (249039) +4 more
core +1 more source
Molecules, 2012 Apoptotic resistance is the main obstacle for treating cancer patients with chemotherapeutic drugs. Multidrug resistance (MDR) is often characterized by the expression of P-glycoprotein (P-gp), a 170-KD ATP-dependent drug efflux protein.
Li-Wu Fu +6 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim +5 more
wiley +1 more source