THE ROLE OF INFLAMMASOME AND CASPASE-1 IN REGULATING ADAPTIVE RESPONSE TO OXIDATIVE STRESS IN MOUSE HEPATOCYTES [PDF]
, 2013 In myeloid cells, oxidative stress can induce the activation of caspase-1 through canonical inflammasome signaling, which leads to the release of proinflammatory cytokines IL-1β/IL-18 and a potentially damaging inflammatory response.
Sun, Qian
core
Caspase-11 controls pyroptosis of lung epithelial cells. [PDF]
, 2018 (A) TC-1 cells were infected with B. thailandensis or the bsaZ mutant in presence or absence of IFNγ. Active caspase-11 was pulled-down from cell lysates using Biotin-VAD-FMK and detected by immunoblot.
Fabio Re (189981) +6 more
core +1 more source
Caspase-1 activation during Eh-macrophage contact degrades cullin-1/5. [PDF]
, 2021 (A, B) THP-1 derived macrophages were pre-incubated with the pan-caspase inhibitor Z-VAD-fmk (100μM) and caspase-1 specific inhibitor Z-YVAD-fmk (100μM) for 1 h followed by stimulation with Eh (10:1 ratio) for 10 min.
Kris Chadee (249039) +4 more
core +1 more source
Evaluation of Cytotoxic and Apoptotic Effects of Simvastatin in Bone Cancer Cell line(MG-63)
Armaghane Danesh Bimonthly Journal, 2020 Background & aim: Cancer is a mismatch between cell growth and death that results in excessive accumulation of cells. Bone cancer is a very serious type of cancer and occurs when osteoporotic cells have problems. The aim of this study was to evaluate the
MA Soltani, T Naji, R Ahmadi
doaj
Expression of Caspases and Their Substrates in the Rat Model of Focal Cerebral Ischemia
Neurobiology of Disease, 2000 Experimental evidence suggests that the massive release of glutamate during experimental brain ischemia both directly and indirectly regulates downstream mechanisms of cell suicide.
Jerzy Krupinski +3 more
doaj +1 more source
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
Journal of Experimental Medicine, 2018 Host-protective caspase-1 activity must be tightly regulated to prevent pathology, but mechanisms controlling the duration of cellular caspase-1 activity are unknown.
D. Boucher +12 more
semanticscholar +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Toxins, 2011 Ricin is a highly toxic type II ribosome-inactivating protein that has potential as a biochemical weapon and as the toxic component of immunotoxins. The unfolded protein response (UPR) is a survival response that helps cells to recover from endoplasmic ...
Wendie S. Cohick +3 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Interactions in the Active Site Loops are Important for Maintaining the Active Site Environment of (Pro)caspase-3 [PDF]
, 2004 Apoptosis is obligatory to development and in maintaining the vital balance between cell growth and death. Commitment to apoptosis involves a proteolytic cascade by a family of cysteine proteases named caspases.
Feeney, Brett
core