Results 51 to 60 of about 30,930,304 (249)
Reconstitution of human pyroptotic cell death in Saccharomyces cerevisiae
Scientific Reports, 2023 Pyroptosis is a lytic form of programmed cell death induced by the activation of gasdermins. The precise mechanism of gasdermin activation by upstream proteases remains incompletely understood.
Yanhao Ji, Christine J. Hawkins
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Unconventional protein secretion by gasdermin pores
, 2023 Unconventional protein secretion (UPS) allows the release of specific leaderless proteins independently of the classical endoplasmic reticulum (ER)-Golgi secretory pathway.
Broz, P., Petr Broz
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Gasdermin E suppresses tumour growth by activating anti-tumour immunity
Nature, 2020 Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1. Gasdermin E (GSDME, also known as DFNA5)-mutated in familial ageing-related hearing loss2-can be cleaved by caspase 3, thereby converting noninflammatory apoptosis to pyroptosis in GSDME-expressing cells3-5. GSDME expression
Zhang, Zhibin +13 more
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Biomolecules, 2023 Background: Gasdermin D, a molecule downstream of the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing inflammasome, forms the membrane pore for the secretion of interleukin (IL)-1β and IL-18, and also mediates ...
Jia Guo +8 more
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, 2011 Review on GSDMA (gasdermin A), with data on DNA, on the protein encoded, and where the gene is ...
Sasaki, H, Saeki, N
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Regulation of Lytic and Non-Lytic Functions of Gasdermin Pores.
, 2022 Pyroptosis is a necrotic form of cell death that was initially found to be induced upon activation of inflammatory caspases by inflammasome complexes.
Broz, P., Rühl, S.
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Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells
Frontiers in Pharmacology, 2021 Pyroptosis is a form of programmed cell death, in which gasdermin E (GSDME) plays an important role in cancer cells, which can be induced by activated caspase-3 on apoptotic stimulation.
Liang Yan +12 more
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, 2012 Review on GSDMB (gasdermin B), with data on DNA, on the protein encoded, and where the gene is ...
Tamura, M, Shiroishi, T
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Induction of Pyroptosis and Its Implications in Cancer Management
Frontiers in Oncology, 2019 Pyroptosis is a gasdermins mediated programmed cell death, which has been widely studied in inflammatory disease models. Recently, there are growing evidences that pyroptosis can be chemically induced in cancer cells without any bacterial or viral ...
Yan-Yang Wang +4 more
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Cell Reports, 2021 Summary: Crohn’s disease (CD) is a kind of refractory intestinal inflammatory diseases. Pyroptosis was recently identified as a gasdermin-mediated proinflammatory cell death.
Gao Tan +4 more
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