Results 31 to 40 of about 4,201 (162)

GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis

Nature Communications, 2023
AbstractPyroptosis, a type of Gasdermin-mediated cell death, contributes to an exacerbation of inflammation. To test the hypothesis that GSDME-mediated pyroptosis aggravates the progression of atherosclerosis, we generate ApoE and GSDME dual deficiency mice.
Yuanyuan Wei, Beidi Lan, Tao Zheng, Lin Yang, Xiaoxia Zhang, Lele Cheng, Gulinigaer Tuerhongjiang, Zuyi Yuan, Yue Wu   +8 more
openaire   +3 more sources

GSDME and its role in cancer: From behind the scenes to the front of the stage

International Journal of Cancer, 2020
AbstractGasdermin E (GSDME), a gene originally involved in hereditary hearing loss, has been associated with several types of cancer in the last two decades. Recently, GSDME was identified as a pore‐forming molecule, which is activated following caspase‐3‐mediated cleavage resulting in so‐called secondary necrosis following apoptotic cell death, or in ...
Elke De Schutter, Lieselot Croes, Joe Ibrahim, Patrick Pauwels, Ken Op de Beeck, Peter Vandenabeele, Guy Van Camp   +6 more
openaire   +4 more sources

Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity

Cell Death and Disease, 2021
Chemotherapy drug-induced nephrotoxicity limits clinical applications for treating cancers. Pyroptosis, a newly discovered programmed cell death, was recently reported to be associated with kidney diseases.
Xiujin Shen, Haibing Wang, Chunhua Weng, Hong Jiang, Jianghua Chen   +4 more
doaj   +1 more source

A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer

Acta Pharmaceutica Sinica B, 2023
It is discovered that activated caspase-3 tends to induce apoptosis in gasdermin E (GSDME)-deficient cells, but pyroptosis in GSDME-sufficient cells. The high GSDME expression and apoptosis resistance of pancreatic ductal adenocarcinoma (PDAC) cells shed
Yang Liu, Xiaowei Zhang, Ping Zhang, Tingting He, Weitao Zhang, Dingyuan Ma, Ping Li, Jun Chen   +7 more
doaj   +1 more source

GSDME Increases Chemotherapeutic Drug Sensitivity by Inducing Pyroptosis in Retinoblastoma Cells

Oxidative Medicine and Cellular Longevity, 2022
Chemotherapy is an important part of retinoblastoma (RB) treatment. However, the development of drug resistance increases the likelihood of treatment failure. Therefore, increasing the sensitivity of chemotherapeutic drugs is very important. Recent research has explored the relationship between the expression level of gasdermin E (GSDME) and drug ...
Fang Li, Qinyun Xia, Lian Ren, Yuhong Nie, He Ren, Xiaoyu Guo, Jinqiang Yu, Yiqiao Xing, Zhen Chen   +8 more
openaire   +2 more sources

Mutation analysis of the GSDME gene in a Chinese family with non-syndromic hearing loss

PLOS ONE, 2022
Background Hearing loss is considered one of the most common sensory nervous system defects, about 60% of which are caused by genetic factors. Mutations in the GSDME gene are responsible for post-lingual, progressive, autosomal dominant hearing loss. This study aimed to characterize the genetic mutations and clinical features of a Chinese GSDME family.
Peiliang Lei, Qingwen Zhu, Wenrong Dong, Siqi Zhang, Yanyan Sun, Xitong Du, Meng Geng, Yuan Jiang   +7 more
openaire   +3 more sources

Characterization of GSDME in amphioxus provides insights into the functional evolution of GSDM-mediated pyroptosis

PLOS Biology, 2023
Members of the gasdermin (GSDM) family are pore-forming effectors that cause membrane permeabilization and pyroptosis, a lytic proinflammatory type of cell death. To reveal the functional evolution of GSDM-mediated pyroptosis at the transition from invertebrates to vertebrates, we conducted functional characterization of amphioxus GSDME (BbGSDME) and ...
Xinli Wang, Xuxia Wei, Yan Lu, Qinghuan Wang, Rong Fu, Yin Wang, Qin Wang, Xiangyan Wang, Shangwu Chen, Anlong Xu, Shaochun Yuan   +10 more
openaire   +3 more sources

Light‐Activatable Nitric Oxide Release via Intramolecular Electron Transfer for Tumor Pyroptosis Induction

Advanced Science, EarlyView.
This work proposes a novel strategy to fabricate unimolecular pyroptosis photoinitiators activated by deep‐red light at low light doses. It relies on a photosensitization mechanism to trigger nitric oxide (NO) release from benzisothiadiazole‐based N‐nitrosanilines without modification of nitro moieties, thereby boosting pyroptosis‐mediated ...
Chuangxin Zhang, Ruipeng Li, Yunxia Wang, Feng Liu, Liheng Feng   +4 more
wiley   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Metformin Inhibited GSDME to Suppress M2 Macrophage Pyroptosis and Maintain M2 Phenotype to Mitigate Cisplatin-Induced Intestinal Inflammation

Biomedicines
Background: The continuous clinical use of cisplatin is prevented by gastrointestinal toxicity. Methods: Cisplatin was used to treat THP-1-derived macrophages to see its differential effects on different subtypes of macrophages.
Ke Jiang, Qi He, Chenhui Wang, Wen Yang, Changdong Zhou, Jian Li, Jiangbo Li, Yuke Cui, Jingqi Shi, Zhenqiao Wei, Yuanyuan Jiao, Ligai Bai, Shengqi Wang, Liang Guo   +13 more
doaj   +1 more source