Results 31 to 40 of about 5,022 (197)

Transcription factor Sp1 transcriptionally enhances GSDME expression for pyroptosis

Cell Death and Disease
Gasdermin-E (GSDME), the executioner of pyroptosis when cleaved by caspase 3, plays a crucial role in tumor defense and the response to chemotherapy drugs in cells.
Jiasong Pan, Yuanyuan Li, Wenqing Gao, Qizhou Jiang, Lu Geng, Jin Ding, Suhua Li, Jixi Li   +7 more
doaj   +3 more sources

OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis

Journal of Experimental & Clinical Cancer Research, 2022
Background Radioresistance is the primary cause of nasopharyngeal carcinoma (NPC) treatment failure. Previous studies have focused on the deficits in cellular apoptosis as a mechanism for radioresistance; however, additional potential death modes ...
Muping Di, Jingjing Miao, Qiuzhong Pan, Zonglong Wu, Boyu Chen, Muru Wang, Jingjing Zhao, Huageng Huang, Jiewen Bai, Qijing Wang, Yan Tang, Yongqiang Li, Jia He, Tong Xiang, Desheng Weng, Lin Wang, Jianchuan Xia, Chong Zhao   +17 more
doaj   +3 more sources

GSDME in cardiovascular diseases: research system and contemporary progress

Frontiers in Immunology
Despite considerable advancements in treatment technologies in recent years, cardiovascular diseases still pose a significant threat to human health.
Zhenzhen Yang, Zilong Luo, Han Zhang, Han Zhang, Junjie Zong, Junjie Zong, Pinyan Huang, Pinyan Huang, Yuqing Niu, Cheng Zhou, Cheng Zhou, Song Wang, Song Wang, Dan Zhang, Dan Zhang   +14 more
doaj   +3 more sources

GSDME knockout alleviates hematopoietic stem cell irradiation injury and aggravates myeloid-biased differentiation [PDF]

Frontiers in Cell and Developmental Biology
BackgroundBone marrow (BM) suppression is the most prevalent dose-limiting side effect of chemotherapy and radiotherapy. Exposure to ionizing radiation (IR) results in acute BM suppression and long-term BM injury.
Lulu Su, Lulu Su, Yinping Dong, Bowen Guan, Yuquan Wang, Yanhua Lu, Xinyue Wang, Wenxuan Li, Qidong Huo, Aimin Meng, Deguan Li   +10 more
doaj   +2 more sources

Epstein–Barr Virus Silences GSDME and Pyroptosis in Gastric Cancer

Microorganisms
Epstein–Barr virus (EBV)-associated gastric carcinoma (EBVaGC) represents a distinct molecular subtype characterized by extensive DNA methylation and altered cell death signaling. This study investigated the regulation and function of gasdermin E (GSDME),
Min-Hyeok Lee, Ju Yeon Lee, Jun Yeob Kim, Yea Rim An, Suk Kyeong Lee   +4 more
doaj   +3 more sources

GSDME-N-induced mitochondrial neurotoxicity in early neurodegeneration was suppressed by nicotine via enhancing autophagic flux

Journal of Translational Medicine
Background Neurodegeneration is a chronic, progressive process initiated by early neurite retraction, a pathological hallmark preceding neuronal death in neurodegenerative disorders such as Parkinson’s disease (PD).
Junjun Zhao, Saitao Qiu, Angyang Guo, Haixia Huang, Wei Wang, Jianliang Zhang   +5 more
doaj   +2 more sources

Research Progress on the Role of GSDME-mediated Pyroptosis in the Treatment of 
Lung Cancer

Zhongguo fei ai za zhi = Chinese journal of lung cancer
Lung cancer causes a significant threat to human health. Despite considerable advancements in the treatment technologies in recent years, the five-year survival rate for lung cancer patients remains low.
Huan LI, Xudong TANG
core   +4 more sources

Gasdermin-E Mediated Pyroptosis—A Novel Mechanism Regulating Migration, Invasion and Release of Inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-like Synoviocytes

Frontiers in Cell and Developmental Biology, 2022
Synovium fibroblast-like synoviocytes (FLSs) are important participants in the pathogenesis of synovitis and joint destruction in rheumatoid arthritis (RA).
Tao Wu, Xue-Pei Zhang, Qian Zhang, Yao-Yao Zou, Jian-Da Ma, Le-Feng Chen, Yao-Wei Zou, Ji-Meng Xue, Ruo-Fan Ma, Zhong Chen, Lie Dai   +10 more
doaj   +1 more source

GSDME deficiency leads to the aggravation of UVB-induced skin inflammation through enhancing recruitment and activation of neutrophils

Cell Death and Disease, 2022
Gasdermin E (GSDME)-mediated pyroptosis is induced in keratinocytes of UVB-challenged skin. The role of GSDME in UVB-caused skin damage remains unknown. To explore the role of GSDME in UVB-induced skin inflammation.
Yujie Chen, Ni Lian, Sihan Chen, Ta Xiao, Yangying Ke, Yiqun Zhang, Changjun Song, Yong Yang, Song Xu, Heng Gu, Xu Chen   +10 more
doaj   +1 more source

Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation

Cell Death and Disease, 2021
Pyroptosis, one kind of inflammatory regulated cell death, is involved in various inflammatory diseases, including acute kidney injury (AKI). Besides Gasdermin D (GSDMD), GSDME is a newly identified mediator of pyroptosis via the cleavage of caspase-3 ...
Weiwei Xia, Yuanyuan Li, Mengying Wu, Qianqian Jin, Qian Wang, Shuzhen Li, Songming Huang, Aihua Zhang, Yue Zhang, Zhanjun Jia   +9 more
doaj   +1 more source