Results 31 to 40 of about 5,373 (177)

Infectious bursal disease virus induces GSDME-dependent pyroptosis via the mitochondrial caspase-9/3 pathway in DF-1 cells. [PDF]

Vet Res
Infectious bursal disease virus (IBDV) is an important avian pathogen that damages the bursa of Fabricius and continues to threaten the poultry industry.
Yuan L, Yang H, Ma S, Xu A, Feng S, Xuan X, Xu S, Yang S, Wang K, Li G, Si H, Huang J, Li Y, Ou C.   +13 more
europepmc   +2 more sources

A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer

Acta Pharmaceutica Sinica B, 2023
It is discovered that activated caspase-3 tends to induce apoptosis in gasdermin E (GSDME)-deficient cells, but pyroptosis in GSDME-sufficient cells. The high GSDME expression and apoptosis resistance of pancreatic ductal adenocarcinoma (PDAC) cells shed
Yang Liu, Xiaowei Zhang, Ping Zhang, Tingting He, Weitao Zhang, Dingyuan Ma, Ping Li, Jun Chen   +7 more
doaj   +1 more source

Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity

Cell Death and Disease, 2021
Chemotherapy drug-induced nephrotoxicity limits clinical applications for treating cancers. Pyroptosis, a newly discovered programmed cell death, was recently reported to be associated with kidney diseases.
Xiujin Shen, Haibing Wang, Chunhua Weng, Hong Jiang, Jianghua Chen   +4 more
doaj   +1 more source

DataSheet2_Antitumor Effect of Simvastatin in Combination With DNA Methyltransferase Inhibitor on Gastric Cancer via GSDME-Mediated Pyroptosis.PDF

, 2022
Gasdermin E (GSDME) is one of the executors of pyroptosis, a type of programmed lytic cell death, which can be triggered by caspase-3 activation upon stimulation.
Yong Jin (566463), Weilin Jin (128742), Xia Wu (203682), Hai Huang (140371), Daxiang Cui (128744), Cunfeng Song (12433605), Ying Xia (222301)   +6 more
core   +1 more source

Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis

, 2021
Secondary necrosis has long been perceived as an uncontrolled process resulting in total lysis of the apoptotic cell. Recently, it was shown that progression of apoptosis to secondary necrosis is regulated by Gasdermin E (GSDME), which requires ...
De Schutter, Elke, De Tender, Caroline, Stremersch, Stephan, op de Beeck, Ken, Braeckmans, Kevin, Riquet, Franck, Pfeuty, Benjamin, Declercq, Wim, Raemdonck, Koen, Ramon, Jana, Vandenabeele, Peter, de Beeck, Ken Op, Riquet, Franck, B, Riquet, Franck B., Elke De Schutter, Franck B. Riquet, Wim Declercq, Stephan Stremersch, Kevin Braeckmans, Jana Ramon, Caroline De Tender, Koen Raemdonck, Ken Op de Beeck, Benjamin Pfeuty, Peter Vandenabeele   +24 more
core   +1 more source

Summary of all reported GSDME variants leading to hearing loss.

, 2022
Summary of all reported GSDME variants leading to hearing loss.
Siqi Zhang (1397044), Meng Geng (13236384), Peiliang Lei (14094102), Qingwen Zhu (3861367), Yanyan Sun (351971), Wenrong Dong (14094105), Xitong Du (14094108), Yuan Jiang (296541)   +7 more
core   +1 more source

Targeted Degradation of STING by a Neutrophil Membrane-Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage. [PDF]

Adv Sci (Weinh)
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Zhang R, Yuan K, Zou H, Qin H, Liu J, Sun J, Zhang F, Wang Y, Wang T, Dai J, Li C, Chen Y, Tu Y, Shi H.   +13 more
europepmc   +2 more sources

Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells [PDF]

, 2021
Pyroptosis is a form of programmed cell death, in which gasdermin E (GSDME) plays an important role in cancer cells, which can be induced by activated caspase-3 on apoptotic stimulation.
Yu-hui Zhang, Wu, G., Shi, S.-S., Tim Forouzanfar, Ma, X.-F., Gang Wu, Fan, J., Hai-yan Lin, Liang Yan, Xue-feng Ma, Hou, D., Zhang, Y.-H., Jun Fan, Liu, Y., Lin, H.-Y., Yan, L., Dan Hou, Shan-shan Shi, Yong Sun, Forouzanfar, T., Sun, Y., Yi Liu   +21 more
core   +1 more source

Elucidation of the role of GSDME during apoptosis-driven secondary necrosis

, 2021
: Although clear evidence exists for the contribution of gasdermin E (GSDME) to hearing loss and tumor biology, the physiological function of GSDME and how it could explain a role in both disorders remained unclear.
De Schutter, Elke
core   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source