Results 41 to 50 of about 5,022 (197)
Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells
Cell Communication and Signaling, 2023 Background Lung cancer is the most lethal malignancy, with non-small cell lung cancer (NSCLC) being the most common type (~ 85%). Abnormal activation of epidermal growth factor receptor (EGFR) promotes the development of NSCLC.
Limei Xu +7 more
doaj +1 more source
Cell Reports, 2021 Summary: Crohn’s disease (CD) is a kind of refractory intestinal inflammatory diseases. Pyroptosis was recently identified as a gasdermin-mediated proinflammatory cell death.
Gao Tan +4 more
doaj +1 more source
Frontiers in Oncology, 2022 ObjectiveTo probe into the role of pyroptosis-related genes in gastric cancer.MethodsTo establish pyroptosis-related genes, observe their expression in gastric cancer, and analyze the prognosis of pyroptosis-related genes in gastric cancer by single ...
Jie Yin +4 more
doaj +1 more source
, 2021 GSDME is a newly recognized executor of cellular pyroptosis, and has been recently implicated in tumor growth and immunity. However, knowledge about the molecular regulators underlying GSDME abundance remains limited.
Chenqiang Jia (11757158) +14 more
core +1 more source
z-DEVD-FMK reduces the cleavage of GSDME.
, 2022 (A, D) Western blotting analysis of full-length GSDME (GSDME-F) and GSDME-N terminal (GSDME-N) in MCF-7 and MDA-MB-231 cells treated by 4f (5 μM) in the presence or absence of z-DEVD-FMK (50 μM). (B, E) Cell viability analysis by CCK8 kit.
Zhi Zhou (154130) +4 more
core +1 more source
Prognostic and Immunological Role of Gasdermin E in Pan-Cancer Analysis
Frontiers in Oncology, 2021 Despite accumulating cell- or animal-based experiments providing the relationship between Gasdermin E (GSDME) and human diseases, especially in malignant cancers, no pan-cancer analysis about the function of GSMDE in cancer management can be available up
Zheng Zhang +6 more
doaj +1 more source
, 2021 GSDME is a newly recognized executor of cellular pyroptosis, and has been recently implicated in tumor growth and immunity. However, knowledge about the molecular regulators underlying GSDME abundance remains limited.
Chenqiang Jia (11757158) +14 more
core +1 more source
Gasdermin E: A Prospective Target for Therapy of Diseases
Frontiers in Pharmacology, 2022 Gasdermin E (GSDME) is a member of the gasdermin protein family, which mediates programmed cell death including apoptosis and pyroptosis. Recently, it was suggested that GSDME is activated by chemotherapeutic drugs to stimulate pyroptosis of cancer cells
Xiu-Xiu Liao +3 more
doaj +1 more source
Cell Death Discovery, 2022 An increase in apoptosis and/or defects in the clearance of apoptotic cells resulting in massive secondary necrosis have been recognized as the main causes of systemic lupus erythematosus (SLE).
Guihu Luo +13 more
doaj +1 more source
DataSheet1_Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy.pdf
, 2021 Pyroptosis is a recently identified type of lytic programmed cell death, in which pores form in the plasma membrane, and cells swell, rupture, and then release their contents, including inflammatory cytokines.
Jing Sun (141206) +5 more
core +1 more source