Results 21 to 30 of about 5,373 (177)
Gasdermin E: A Prospective Target for Therapy of Diseases
Frontiers in Pharmacology, 2022 Gasdermin E (GSDME) is a member of the gasdermin protein family, which mediates programmed cell death including apoptosis and pyroptosis. Recently, it was suggested that GSDME is activated by chemotherapeutic drugs to stimulate pyroptosis of cancer cells
Xiu-Xiu Liao +3 more
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z-DEVD-FMK reduces the cleavage of GSDME.
, 2022 (A, D) Western blotting analysis of full-length GSDME (GSDME-F) and GSDME-N terminal (GSDME-N) in MCF-7 and MDA-MB-231 cells treated by 4f (5 μM) in the presence or absence of z-DEVD-FMK (50 μM). (B, E) Cell viability analysis by CCK8 kit.
Zhi Zhou (154130) +4 more
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Cell Death Discovery, 2022 An increase in apoptosis and/or defects in the clearance of apoptotic cells resulting in massive secondary necrosis have been recognized as the main causes of systemic lupus erythematosus (SLE).
Guihu Luo +13 more
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GSDME rather than GSDMD is cleaved during cell pyroptosis of breast cancer cells induced by 4f.
, 2022 (A, B) Full-length GSDMD (GSDMD-F) and GSDMD-C terminal (GSDMD-C) were detected by western blotting in MCF-7 and MDA-MB-231 cells treated with different doses of 4f.
Zhi Zhou (154130) +4 more
core +1 more source
DataSheet1_Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy.pdf
, 2021 Pyroptosis is a recently identified type of lytic programmed cell death, in which pores form in the plasma membrane, and cells swell, rupture, and then release their contents, including inflammatory cytokines.
Jing Sun (141206) +5 more
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, 2022 Additional file 1: Figure S1. Radiotherapy induces GSDME-dependent pyroptosis in NPC cells through the intrinsic mitochondrial apoptotic pathway. Figure S2. Upregulation of GSDME enhances pyroptosis and radiosensitivity in NPC cells in vitro.
Yan Tang (195081) +17 more
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Prognostic and Immunological Role of Gasdermin E in Pan-Cancer Analysis
Frontiers in Oncology, 2021 Despite accumulating cell- or animal-based experiments providing the relationship between Gasdermin E (GSDME) and human diseases, especially in malignant cancers, no pan-cancer analysis about the function of GSMDE in cancer management can be available up
Zheng Zhang +6 more
doaj +1 more source
, 2021 GSDME is a newly recognized executor of cellular pyroptosis, and has been recently implicated in tumor growth and immunity. However, knowledge about the molecular regulators underlying GSDME abundance remains limited.
Chenqiang Jia (11757158) +14 more
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, 2021 GSDME is a newly recognized executor of cellular pyroptosis, and has been recently implicated in tumor growth and immunity. However, knowledge about the molecular regulators underlying GSDME abundance remains limited.
Chenqiang Jia (11757158) +14 more
core +1 more source
GSDME-dependent pyroptosis signaling pathway in diabetic nephropathy
, 2023 Diabetic nephropathy (DN) is one of the serious chronic microvascular complications of diabetes, and leads to the increased morbidity and mortality in diabetic patients.
Zhi Qi +15 more
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