Results 21 to 30 of about 4,201 (162)

Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation

Cell Death and Disease, 2021
Pyroptosis, one kind of inflammatory regulated cell death, is involved in various inflammatory diseases, including acute kidney injury (AKI). Besides Gasdermin D (GSDMD), GSDME is a newly identified mediator of pyroptosis via the cleavage of caspase-3 ...
Weiwei Xia, Yuanyuan Li, Mengying Wu, Qianqian Jin, Qian Wang, Shuzhen Li, Songming Huang, Aihua Zhang, Yue Zhang, Zhanjun Jia   +9 more
doaj   +1 more source

Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells

Cell Communication and Signaling, 2023
Background Lung cancer is the most lethal malignancy, with non-small cell lung cancer (NSCLC) being the most common type (~ 85%). Abnormal activation of epidermal growth factor receptor (EGFR) promotes the development of NSCLC.
Limei Xu, Feifei Shi, Yingdi Wu, Shun Yao, Yingying Wang, Xukai Jiang, Ling Su, Xiangguo Liu   +7 more
doaj   +1 more source

GSDME-dependent pyroptosis signaling pathway in diabetic nephropathy

Cell Death Discovery, 2023
AbstractDiabetic nephropathy (DN) is one of the serious chronic microvascular complications of diabetes, and leads to the increased morbidity and mortality in diabetic patients. Gasdermin E (GSDME)-dependent pyroptosis signaling pathway plays important roles in a variety of physiological and pathological processes. However, its role and mechanism in DN
Shengyu Li, Lifeng Feng, Guangru Li, Ruiqing Liu, Changzhen Ma, Lin Wang, Aijiao Gao, Chang Liu, Yujie Cui, Zecheng Jiang, Yuhang Xie, Qiang Wu, Xia Wang, Liang Yang, Zhi Qi, Yanna Shen   +15 more
openaire   +3 more sources

Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn’s disease by promoting intestinal inflammation

Cell Reports, 2021
Summary: Crohn’s disease (CD) is a kind of refractory intestinal inflammatory diseases. Pyroptosis was recently identified as a gasdermin-mediated proinflammatory cell death.
Gao Tan, Chongyang Huang, Jiaye Chen, Bingxia Chen, Fachao Zhi   +4 more
doaj   +1 more source

Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis [PDF]

Cellular and Molecular Life Sciences, 2021
AbstractSecondary necrosis has long been perceived as an uncontrolled process resulting in total lysis of the apoptotic cell. Recently, it was shown that progression of apoptosis to secondary necrosis is regulated by Gasdermin E (GSDME), which requires activation by caspase-3.
de Schutter, Elke, Ramon, Jana, Pfeuty, Benjamin, de Tender, Caroline, Stremersch, Stephan, Raemdonck, Koen, de Beeck, Ken Op, Declercq, Wim, Riquet, Franck, Braeckmans, Kevin, Vandenabeele, Peter   +10 more
openaire   +9 more sources

Investigating the Prognostic Significance of Pyroptosis-Related Genes in Gastric Cancer and Their Impact on Cells’ Biological Functions

Frontiers in Oncology, 2022
ObjectiveTo probe into the role of pyroptosis-related genes in gastric cancer.MethodsTo establish pyroptosis-related genes, observe their expression in gastric cancer, and analyze the prognosis of pyroptosis-related genes in gastric cancer by single ...
Jie Yin, Gang Che, Wankun Wang, Shitu Chen, Jian Liu   +4 more
doaj   +1 more source

Gasdermin E: A Prospective Target for Therapy of Diseases

Frontiers in Pharmacology, 2022
Gasdermin E (GSDME) is a member of the gasdermin protein family, which mediates programmed cell death including apoptosis and pyroptosis. Recently, it was suggested that GSDME is activated by chemotherapeutic drugs to stimulate pyroptosis of cancer cells
Xiu-Xiu Liao, Yong-Zhao Dai, Yao-Zhong Zhao, Ke Nie   +3 more
doaj   +1 more source

Prognostic and Immunological Role of Gasdermin E in Pan-Cancer Analysis

Frontiers in Oncology, 2021
Despite accumulating cell- or animal-based experiments providing the relationship between Gasdermin E (GSDME) and human diseases, especially in malignant cancers, no pan-cancer analysis about the function of GSMDE in cancer management can be available up
Zheng Zhang, Shuangshuang Zhao, Haizhen Yang, Yanwei Chen, Huahui Feng, Maohui An, Baoding Chen   +6 more
doaj   +1 more source

Blocking GSDME-mediated pyroptosis in renal tubular epithelial cells alleviates disease activity in lupus mice

Cell Death Discovery, 2022
An increase in apoptosis and/or defects in the clearance of apoptotic cells resulting in massive secondary necrosis have been recognized as the main causes of systemic lupus erythematosus (SLE).
Guihu Luo, Yi He, Fangyuan Yang, Zeqing Zhai, Jiaochan Han, Wenchao Xu, Jialin Zhang, Lili Zhuang, Yanan Zhang, Yehao Li, Rui Song, Xiaoqing Luo, Jianheng Liang, Erwei Sun   +13 more
doaj   +1 more source

FOXO3 upregulates and activates GSDME to trigger myeloma cell pyroptosis. [PDF]

Int J Biol Sci
Induction of pyroptosis is considered as a novel strategy for the treatment of multiple myeloma, but the potential targets remain unknown. In the present study, we found that GSDME, a key executor of pyroptosis, is the mostly downregulated pyroptosis-related gene in MM cells and its low expression predicts poor prognosis of MM patients.
Wang Y, Wang Y, Cui Y, He Y, Yang Y, Zhou W, Liu L, Wang H, Liu M, Wei Y, Huang Z, Wei X, Mao X.   +12 more
europepmc   +4 more sources