Results 21 to 30 of about 5,022 (197)

Penfluridol Triggers GSDME-Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy. [PDF]

Adv Sci (Weinh)
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Li L, Li D, Chen D, Dian Y, Yao L, Su H, Guo Z, Zhao D, Wu Z, Zeng F, Zhang C, Deng G.   +11 more
europepmc   +2 more sources

Targeted Degradation of STING by a Neutrophil Membrane-Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage. [PDF]

Adv Sci (Weinh)
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Zhang R, Yuan K, Zou H, Qin H, Liu J, Sun J, Zhang F, Wang Y, Wang T, Dai J, Li C, Chen Y, Tu Y, Shi H.   +13 more
europepmc   +2 more sources

Oncolytic virus-delivered GSDME: Unlocking pyroptosis to improve dendritic cell function and amplify cytotoxic T cell response [PDF]

Molecular Therapy: Oncology
Oncolytic virotherapy is a promising strategy for advanced cancers, but clinical success remains limited. Combining oncolytic viruses with immunogenic cell death modalities offers a potential solution.
Sabrina Schneider, Theresa Schwaiger, Joelle Kröll, Ioannes Basbas, Fabian Martin, Dongyue Xin, Elke Podgorschek, Ilona Arnkil, Marlies Glatz, Melissa Mayr, Monika Petersson, Stefan Scheidl, Stefan Schneeberger, Krishna Das, Bart Spiesschaert, Christian Mandl, Sebastian Carotta, Christiane B. Knobbe-Thomsen, Knut Elbers, Tobias Nolden   +19 more
doaj   +2 more sources

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis. [PDF]

Adv Sci (Weinh)
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Hong Y, Wu H, Wang W, Zhang X, Chen Q, Hu Y, Zha Z.   +6 more
europepmc   +2 more sources

The Very Virulent IBDV Viral Protein VP3 Promotes the Caspase-3 Mediated Cleavage of GSDME [PDF]

Veterinary Sciences
The infectious bursal disease virus (IBDV) can cause severe immunosuppression and high mortality in chickens, posing a significant threat to the poultry farming industry.
Tao Zhang, Suyan Wang, Xiaole Qi, Lijie Tang, Yulong Gao   +4 more
doaj   +2 more sources

Metformin Inhibited GSDME to Suppress M2 Macrophage Pyroptosis and Maintain M2 Phenotype to Mitigate Cisplatin-Induced Intestinal Inflammation

Biomedicines
Background: The continuous clinical use of cisplatin is prevented by gastrointestinal toxicity. Methods: Cisplatin was used to treat THP-1-derived macrophages to see its differential effects on different subtypes of macrophages.
Ke Jiang, Qi He, Chenhui Wang, Wen Yang, Changdong Zhou, Jian Li, Jiangbo Li, Yuke Cui, Jingqi Shi, Zhenqiao Wei, Yuanyuan Jiao, Ligai Bai, Shengqi Wang, Liang Guo   +13 more
doaj   +2 more sources

TNFSF15 inhibits progression of diabetic retinopathy by blocking pyroptosis via interacting with GSDME

Cell Death and Disease
Diabetic retinopathy is a common microvascular complication of diabetes and a leading cause of blindness. Pyroptosis has emerged as a mechanism of cell death involved in diabetic retinopathy pathology.
Hongkun Zhao, Yating Dai, Yunqin Li, Juanjuan Li, Hua Li   +4 more
doaj   +2 more sources

A Supramolecular Thermal Switch for Precision Pyroptosis via Host-Guest Recognition and Electrostatic Interactions. [PDF]

Adv Sci (Weinh)
A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Wu D, Zhou J, Cao Y, Ping K, Zhao B, Yang Y, Yu C, Yu X, Qi S.   +8 more
europepmc   +2 more sources

The Role and Mechanism of GSDME-Dependent Pyroptosis in Cochlear Marginal Cells Injury by Cisplatin

Biomedicines
Background: Elucidating the mechanisms underlying cisplatin-induced ototoxicity is critical for the clinical management of hearing loss. While cisplatin is known to penetrate the inner ear via the blood-labyrinth barrier in the stria vascularis, its ...
Wenyang Lei, Wenting Yu, Ting Li, Wei Tang, Shimin Zong, Hongjun Xiao   +5 more
doaj   +2 more sources

Compound loss of GSDMD and GSDME function is necessary to achieve maximal therapeutic effect in colitis [PDF]

Journal of Translational Autoimmunity, 2022
Gasdermin D (GSDMD) and gasdermin E (GSDME) perpetuate inflammation by mediating the release of cytokines such as interleukin-1β (IL-1β) and IL-18. However, not only are the actions of GSDMD in colitis still controversial, but its interplay with GSDME in
Jianqiu Xiao, Kai Sun, Chun Wang, Yousef Abu-Amer, Gabriel Mbalaviele   +4 more
doaj   +2 more sources