Results 51 to 60 of about 5,022 (197)

GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis

Nature Communications, 2023
AbstractPyroptosis, a type of Gasdermin-mediated cell death, contributes to an exacerbation of inflammation. To test the hypothesis that GSDME-mediated pyroptosis aggravates the progression of atherosclerosis, we generate ApoE and GSDME dual deficiency mice.
Yuanyuan Wei, Beidi Lan, Tao Zheng, Lin Yang, Xiaoxia Zhang, Lele Cheng, Gulinigaer Tuerhongjiang, Zuyi Yuan, Yue Wu   +8 more
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GSDME expression in breast cancer after decitabine treatment.

, 2023
A and B. Breast cancer cell lines were treated with 0.2 uM, 0.5 uM, 1 uM and 2 uM decitabine for 72h and GSDME expression levels were quantified by Western blot analysis.
Maodong Leng (14716900), Ying Shi (115282), Weihua Gong (471435), Panpan Fang (5476334)   +3 more
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Additional file 1 of OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis

, 2022
Additional file 1: Figure S1. Radiotherapy induces GSDME-dependent pyroptosis in NPC cells through the intrinsic mitochondrial apoptotic pathway. Figure S2. Upregulation of GSDME enhances pyroptosis and radiosensitivity in NPC cells in vitro.
Yan Tang (195081), Jiewen Bai (14148954), Yongqiang Li (420174), Desheng Weng (14148957), Jingjing Miao (9366743), Jingjing Zhao (129177), Jia He (89641), Muping Di (14148945), Tong Xiang (556763), Lin Wang (11986), Chong Zhao (495389), Qiuzhong Pan (6075821), Huageng Huang (14148951), Jianchuan Xia (3876043), Zonglong Wu (10945215), Boyu Chen (5621660), Muru Wang (14148948), Qijing Wang (4031888)   +17 more
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A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer

Acta Pharmaceutica Sinica B, 2023
It is discovered that activated caspase-3 tends to induce apoptosis in gasdermin E (GSDME)-deficient cells, but pyroptosis in GSDME-sufficient cells. The high GSDME expression and apoptosis resistance of pancreatic ductal adenocarcinoma (PDAC) cells shed
Yang Liu, Xiaowei Zhang, Ping Zhang, Tingting He, Weitao Zhang, Dingyuan Ma, Ping Li, Jun Chen   +7 more
doaj   +1 more source

Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity

Cell Death and Disease, 2021
Chemotherapy drug-induced nephrotoxicity limits clinical applications for treating cancers. Pyroptosis, a newly discovered programmed cell death, was recently reported to be associated with kidney diseases.
Xiujin Shen, Haibing Wang, Chunhua Weng, Hong Jiang, Jianghua Chen   +4 more
doaj   +1 more source

Antitumor Effect of Simvastatin in Combination With DNA Methyltransferase Inhibitor on Gastric Cancer via GSDME-Mediated Pyroptosis

Frontiers in Pharmacology, 2022
Gasdermin E (GSDME) is one of the executors of pyroptosis, a type of programmed lytic cell death, which can be triggered by caspase-3 activation upon stimulation.
Ying Xia, Ying Xia, Ying Xia, Ying Xia, Yong Jin, Yong Jin, Daxiang Cui, Xia Wu, Cunfeng Song, Weilin Jin, Weilin Jin, Hai Huang, Hai Huang   +12 more
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GSDME Increases Chemotherapeutic Drug Sensitivity by Inducing Pyroptosis in Retinoblastoma Cells

Oxidative Medicine and Cellular Longevity, 2022
Chemotherapy is an important part of retinoblastoma (RB) treatment. However, the development of drug resistance increases the likelihood of treatment failure. Therefore, increasing the sensitivity of chemotherapeutic drugs is very important. Recent research has explored the relationship between the expression level of gasdermin E (GSDME) and drug ...
Fang Li, Qinyun Xia, Lian Ren, Yuhong Nie, He Ren, Xiaoyu Guo, Jinqiang Yu, Yiqiao Xing, Zhen Chen   +8 more
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Mutation analysis of the GSDME gene in a Chinese family with non-syndromic hearing loss

PLOS ONE, 2022
Background Hearing loss is considered one of the most common sensory nervous system defects, about 60% of which are caused by genetic factors. Mutations in the GSDME gene are responsible for post-lingual, progressive, autosomal dominant hearing loss. This study aimed to characterize the genetic mutations and clinical features of a Chinese GSDME family.
Peiliang Lei, Qingwen Zhu, Wenrong Dong, Siqi Zhang, Yanyan Sun, Xitong Du, Meng Geng, Yuan Jiang   +7 more
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Characterization of GSDME in amphioxus provides insights into the functional evolution of GSDM-mediated pyroptosis

PLOS Biology, 2023
Members of the gasdermin (GSDM) family are pore-forming effectors that cause membrane permeabilization and pyroptosis, a lytic proinflammatory type of cell death. To reveal the functional evolution of GSDM-mediated pyroptosis at the transition from invertebrates to vertebrates, we conducted functional characterization of amphioxus GSDME (BbGSDME) and ...
Xinli Wang, Xuxia Wei, Yan Lu, Qinghuan Wang, Rong Fu, Yin Wang, Qin Wang, Xiangyan Wang, Shangwu Chen, Anlong Xu, Shaochun Yuan   +10 more
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Elucidation of the role of GSDME during apoptosis-driven secondary necrosis

, 2021
: Although clear evidence exists for the contribution of gasdermin E (GSDME) to hearing loss and tumor biology, the physiological function of GSDME and how it could explain a role in both disorders remained unclear.
De Schutter, Elke
core   +1 more source