Results 71 to 80 of about 4,201 (162)

The Role and Mechanism of GSDME-Dependent Pyroptosis in Cochlear Marginal Cells Injury by Cisplatin

Biomedicines
Background: Elucidating the mechanisms underlying cisplatin-induced ototoxicity is critical for the clinical management of hearing loss. While cisplatin is known to penetrate the inner ear via the blood-labyrinth barrier in the stria vascularis, its ...
Wenyang Lei, Wenting Yu, Ting Li, Wei Tang, Shimin Zong, Hongjun Xiao   +5 more
doaj   +1 more source

Activation of GSDME by all- trans -retinal increases sensitivity to photoreceptor ferroptosis

International Journal of Biological Sciences
Impaired clearance of all-trans-retinal (atRAL) due to visual cycle dysfunction contributes to photoreceptor atrophy, a key pathological hallmark of Stargardt disease type 1 (STGD1) and dry age-related macular degeneration (AMD). Prior studies have shown that light-induced atRAL accumulation promotes ferroptosis and activates gasdermin E (GSDME) in ...
Yang, Bo, Yang, Kunhuan, Chen, Yuling, Xi, Ruitong, Han, Jiahuai, Li, Shiying, Chen, Jingmeng, Wu, Yalin   +7 more
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Chemotherapy-Activated Caspase 3 Cleaves GSDME to Drive Pyroptosis [PDF]

Cancer Discovery, 2017
Abstract GSMDE promotes a switch of chemotherapy-mediated cell death from apoptosis to pyroptosis.
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Gasdermin‐E‐Dependent Non‐Canonical Pyroptosis Promotes Drug‐Induced Liver Failure by Promoting CPS1 deISGylation and Degradation

Advanced Science
Drug‐induced liver injury (DILI) is a significant global health issue that poses high mortality and morbidity risks. One commonly observed cause of DILI is acetaminophen (APAP) overdose. GSDME is an effector protein that induces non‐canonical pyroptosis.
Shen‐Xi Ouyang, Jia‐Hui Zhu, Qi Cao, Jian Liu, Zhen Zhang, Yan Zhang, Jing‐Wen Wu, Si‐Jia Sun, Jiang‐Tao Fu, Yi‐Ting Chen, Jie Tong, Yi Liu, Jia‐Bao Zhang, Fu‐Ming Shen, Dong‐Jie Li, Pei Wang   +15 more
doaj   +1 more source

Oncolytic virus-delivered GSDME: Unlocking pyroptosis to improve dendritic cell function and amplify cytotoxic T cell response

Molecular Therapy: Oncology
Oncolytic virotherapy is a promising strategy for advanced cancers, but clinical success remains limited. Combining oncolytic viruses with immunogenic cell death modalities offers a potential solution.
Sabrina Schneider, Theresa Schwaiger, Joelle Kröll, Ioannes Basbas, Fabian Martin, Dongyue Xin, Elke Podgorschek, Ilona Arnkil, Marlies Glatz, Melissa Mayr, Monika Petersson, Stefan Scheidl, Stefan Schneeberger, Krishna Das, Bart Spiesschaert, Christian Mandl, Sebastian Carotta, Christiane B. Knobbe-Thomsen, Knut Elbers, Tobias Nolden   +19 more
doaj   +1 more source

Fosinopril mediates antitumor efficacy by inducing GSDME-dependent pyroptosis in NSCLC

Cell Death Discovery
Abstract Repurposing existing drugs offers a promising approach to cancer therapy. Fosinopril, an angiotensin converting enzyme inhibitor (ACEI) approved for hypertension, has demonstrated antitumor effects in hepatocellular carcinoma. However, its activity in non-small cell lung cancer (NSCLC) remains poorly understood.
Yue Gao, Xinyue Zhai, Caixia Zhang, Hongmei Zhao, Bing Ji, Ruolan Sun, Xiaoyan Du, Yilin Du, Shengxiang Gao, Yuqiang Zhang, Tao Wang   +10 more
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Caspase-3 Promotes Diabetic Kidney Disease Through Gasdermin E-Mediated Progression to Secondary Necrosis During Apoptosis

Diabetes, Metabolic Syndrome and Obesity, 2020
Si Wen,1,* Zhao-Hua Wang,2,* Cong-Xiao Zhang,1 Ying Yang,1 Qiu-Ling Fan1 1Department of Nephrology, First Hospital of China Medical University, Shenyang, People’s Republic of China; 2Affiliated Dalian Friendship Hospital of Dalian Medical ...
Wen S, Wang ZH, Zhang CX, Yang Y, Fan QL
doaj  

Celastrol activates caspase-3/GSDME-dependent pyroptosis in tumor cells by inducing endoplasmic reticulum stress

Journal of Traditional Chinese Medical Sciences
Objective: To investigate the pyroptosis-inducing effects of celastrol on tumor cells and to explore the potential mechanisms involved, specifically focusing on the role of the caspase-3/gasdermin E (GSDME) signaling pathway and the impact of endoplasmic
Jiajian Guo, Dongxiao Cui, Yuping Tang, Sanjiao Wang, Cuiyan Ma, Wenfu Ma   +5 more
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GSDME knockout alleviates hematopoietic stem cell irradiation injury and aggravates myeloid-biased differentiation

Frontiers in Cell and Developmental Biology
BackgroundBone marrow (BM) suppression is the most prevalent dose-limiting side effect of chemotherapy and radiotherapy. Exposure to ionizing radiation (IR) results in acute BM suppression and long-term BM injury.
Lulu Su, Lulu Su, Yinping Dong, Bowen Guan, Yuquan Wang, Yanhua Lu, Xinyue Wang, Wenxuan Li, Qidong Huo, Aimin Meng, Deguan Li   +10 more
doaj   +1 more source

Endogenous HMGB1 regulates GSDME-mediated pyroptosis via ROS/ERK1/2/caspase-3/GSDME signaling in neuroblastoma.

American journal of cancer research
Pyroptosis, a newly discovered mode of programmed cell death (PCD), is important in the regulation of cancer development. High mobility group box 1 (HMGB1) is a non-histone nuclear protein that is closely related to tumor development and chemotherapy resistance.
Chen-Ying, Fan, Fang-Hua, Ye, Min, Peng, Jia-Jia, Dong, Wen-Wen, Chai, Wen-Jun, Deng, Hui, Zhang, Liang-Chun, Yang   +7 more
openaire   +1 more source