Results 71 to 80 of about 5,022 (197)

Expression levels of caspase‐3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer

Cancer Reports, 2022
Background Pyroptosis plays a dual role in the development of cancer and malignancy; as such, it may potentially be a new target for cancer treatment. However, the inflammatory response to pyroptosis may have adverse effects on the body.
Yuan‐Li Huang, Guang‐Hui Zhang, Qing Zhu, Xia Wu, Li‐Gao Wu   +4 more
doaj   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Activation of GSDME by Lithospermum erythrorhizon drives pyroptotic cell death

Journal of Traditional Chinese Medical Sciences, 2023
Objective: To reveal GSDME-executed pyroptosis in cancer cells induced by the Chinese traditional herbal medicine plant Lithospermum erythrorhizon (L. erythrorhizon, Zi Cao) and to investigate the potential mechanism. Methods: L. erythrorhizon was extracted by ultrasonication in 95% ethanol, and determined using high-performance liquid chromatography ...
Sanjiao Wang, Zhaoheng Liu, Jiajian Guo, Yunqian Li, Yue Zhang, Mingrui Yang, Guoqi Niu, Wenfu Ma   +7 more
openaire   +2 more sources

GSDME mediated pyroptosis drives CCL5 secretion and dictates proteasome inhibitor efficacy in solid tumors

Pharmacological Research
Proteasome inhibitors show limited efficacy against solid tumors. We previously show the combination of Bortezomib with ammonium tetrathiomolybdate (TM) or AMD3100 could inhibit breast cancer growth rely on intact immune system. However, it remains to be
Dongyang Tang, Josh Haipeng Lei, Shiqi Lin, Jingbo Zhou, Xiaoran Wu, Yunfeng Qiao, Heng Sun, Qianqian Chen, Fuqiang Xing, Xiaojin Wang, Xiaoling Xu, Chu-Xia Deng   +11 more
doaj   +1 more source

ZNF460 Promotes GSDME-Driven Pyroptosis via PKM2 Transcriptional Activation in Aortic Dissection

Reviews in Cardiovascular Medicine
Background: Aortic dissection (AD) is a cardiovascular emergency with high mortality; however, the underlying molecular pathophysiology of AD remains incompletely understood. Pyroptosis, a proinflammatory form of programmed cell death,
Quanlin Yang, Xin Shao, Zihe Zheng, Mingliang Li, Changbo Xiao, Bo Chen, Guowei Tu, Ben Huang, Xiaofu Dai   +8 more
doaj   +1 more source

Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

Angewandte Chemie, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

DataSheet1_Antitumor Effect of Simvastatin in Combination With DNA Methyltransferase Inhibitor on Gastric Cancer via GSDME-Mediated Pyroptosis.PDF

, 2022
Gasdermin E (GSDME) is one of the executors of pyroptosis, a type of programmed lytic cell death, which can be triggered by caspase-3 activation upon stimulation.
Yong Jin (566463), Weilin Jin (128742), Xia Wu (203682), Hai Huang (140371), Daxiang Cui (128744), Cunfeng Song (12433605), Ying Xia (222301)   +6 more
core   +1 more source

Transcriptomic insights into GSDME-driven pyroptosis in head and neck cancer

Scientific Reports
This study investigates the expression of pyroptosis-related genes (PRGs) in head and neck squamous cell carcinoma (HNSCC) and their potential role in the tumor immune microenvironment. Additionally, we conducted an in-depth transcriptomic analysis of HNSCC with high GSDME expression.
Hao, Fengxiang, Qin, Danlei, Li, Ran, Li, Xia, Hou, Jiayi, Zhao, Bin   +5 more
openaire   +2 more sources

Summary of all reported GSDME variants leading to hearing loss.

, 2022
Summary of all reported GSDME variants leading to hearing loss.
Siqi Zhang (1397044), Meng Geng (13236384), Peiliang Lei (14094102), Qingwen Zhu (3861367), Yanyan Sun (351971), Wenrong Dong (14094105), Xitong Du (14094108), Yuan Jiang (296541)   +7 more
core   +1 more source

Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice.

, 2022
Millions of patients suffer from silicosis, but it remains an uncurable disease due to its unclear pathogenic mechanisms. Though the Nlrp3 inflammasome is involved in silicosis pathogenesis, inhibition of its classic downstream factors, Caspase-1 and ...
Jingwen Pei, Jingyu Chen, Ji Zhang, Xiang Gao, Visarut Codey Buranasudja, Lulu Kang, Hourong Cai, Yufang Wang, Zhaoyu Lin, Jinghong Dai, Peiliang Shi, Yujie Zou, Yaqiong Tian   +12 more
core   +1 more source