Results 81 to 90 of about 4,201 (162)

Characterization of the GSDMA- and GSDME-mediated pyroptosis pathway in ducks

Abstract Pyroptosis is an inflammatory programmed cell death mediated by gasdermin (GSDM) proteins, playing an important role in both physiological and pathological processes. While humans and other mammals possess multiple functional GSDM members (GSDMA-E) that execute pyroptosis through their pore-forming N-terminal domains, the duck genome ...
Ruihua Zhang, Hui Yan, Lei Bei, Mingrui Zhao, Lin Ju, Lingxuan Zhang, Hucheng Fan, Shijin Jiang   +7 more
openaire   +1 more source

GSDME-N-induced mitochondrial neurotoxicity in early neurodegeneration was suppressed by nicotine via enhancing autophagic flux

Journal of Translational Medicine
Background Neurodegeneration is a chronic, progressive process initiated by early neurite retraction, a pathological hallmark preceding neuronal death in neurodegenerative disorders such as Parkinson’s disease (PD).
Junjun Zhao, Saitao Qiu, Angyang Guo, Haixia Huang, Wei Wang, Jianliang Zhang   +5 more
doaj   +1 more source

GSDME : from tumor suppressor gene to biomarker

, 2019
Abstract: abstract not ...
openaire   +1 more source

Cholestane-3β,5α,6β-triol induces cancer cell death by activating GSDME-mediated pyroptosis

Frontiers in Pharmacology
BackgroundTrihydroxysterols and their analogues accumulate in several pathologies, including neurodegenerative diseases, cancers, and atherosclerosis.
Jiaxi Chen, Yuan He, Min Zhao, Zihan Liu, Zixin Su, Chuanzhou Li, Chuanzhou Li, Chen Yang, Chen Yang, Jieping Zhang, Shuichun Mao, Hua Han, Zhenyu Cai, Wen Zhang, Wen Zhang   +14 more
doaj   +1 more source

Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice

Nature Communications
Gasdermin E (GSDME) is known as a key executive protein of pro-inflammatory pyroptosis. However, the function diversity of GSDME needs further investigation. Here, we show that GSDME expression is downregulated in kidney tissues after cisplatin treatment
Qingzhou Chen, Pengxiao Sun, Jiaxin Zhou, Tantan Long, An Xiao, Zhuoliang Liu, Shihui Xu, Wenjing Lei, Rui Zhang, Jianwei Tian, Miaomiao Zhou, Zheng Hu, Fengxin Zhu, Jing Nie   +13 more
doaj   +1 more source

Ocifisertib alleviates the gasdermin D-independent pyroptosis of nucleus pulposus cells by targeting GSDME

Scientific Reports
This study aimed to elucidate the cellular and molecular mechanisms of GSDME in GSDMD independent nucleus pulposus (NP) cell pyroptosis. We analyzed microarray datasets to identify differentially expressed genes (DEGs) in the progression of ...
Yu Lin, Qiyong Chen, Shaoqiang Liu, Boling Liu   +3 more
doaj   +1 more source

Pyroptosis‐Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple‐Negative Breast Cancer

Advanced Science
Pyroptosis has attracted significant attention for its role in cancer chemotherapy and immunotherapy. However, few drugs have been reported to induce pyroptosis via the Caspase‐3/gasdermin E (GSDME) pathway.
Xinda Yang, Chuansheng Xu, Youliang Zeng, Chunhui Wang, Yan Gao, Jie Ding, Sirui Chen, Yuheng Pan, Xin Zhang, Zongwan Mao, Shuo Shi   +10 more
doaj   +1 more source

IL-17RA Promotes Cigarette Smoke-Induced Alveolar Epithelial Cell Pyroptosis in COPD via Dual Activation of the NLRP3/Caspase1/GSDMD and NF-κB/GSDME Pathways. [PDF]

J Inflamm Res
An X, Gu Y, Zhou J, Liu Y, Yu S, Zhang L, Ouyang Y.   +6 more
europepmc   +1 more source

Gasdermin E: a missing link in muscle regeneration. [PDF]

J Clin Invest
Krishna S, Rafael-Fortney JA.
europepmc   +1 more source

[Research Progress on the Role of GSDME-mediated Pyroptosis in the Treatment of 
Lung Cancer].

Zhongguo fei ai za zhi = Chinese journal of lung cancer
Lung cancer causes a significant threat to human health. Despite considerable advancements in the treatment technologies in recent years, the five-year survival rate for lung cancer patients remains low. In this context, the discovery of pyroptosis, a unique cell death mechanism, offers a novel perspective for exploring new pathways of lung cancer ...
Huan LI, Xudong TANG
openaire   +2 more sources