Results 81 to 90 of about 5,022 (197)
FOXO3 upregulates and activates GSDME to trigger myeloma cell pyroptosis
International Journal of Biological SciencesInduction of pyroptosis is considered as a novel strategy for the treatment of multiple myeloma, but the potential targets remain unknown. In the present study, we found that GSDME, a key executor of pyroptosis, is the mostly downregulated pyroptosis-related gene in MM cells and its low expression predicts poor prognosis of MM patients.
Wang, Yaner +12 more
openaire +3 more sources
Inhibition of Gsdmd and Gsdme-dependent pyroptosis impairs immune cells infiltration in lung.
, 2022 a, Immunofluorescence images of neutrophils (CD11b+Ly6G+) and monocytes (CD11b+Ly6C+) in lung tissues of WT, Nlrp3-/-, Caspase-1-/-, Gsdmd-/-, Gsdme-/- and Gsdmd-/-Gsdme-/- mice 14 days after installation of PBS or silica, n = 3.
Yujie Zou (408340) +12 more
core +1 more source
Intestinal mucositis is a clinically significant adverse event of cancer chemotherapy, particularly in regimens containing irinotecan. Gasdermin E (GSDME) is a pore-forming protein that functions as a molecular switch between apoptosis and pyroptosis and
Yasumitsu Nagao +14 more
core +1 more source
The sequence alignments of GSDME and PJVK with secondary structure elements.
, 2023 The sequence alignments of GSDME and PJVK with secondary structure elements.
Xinli Wang (300814) +10 more
core +1 more source
Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics
MedComm – Oncology, Volume 5, Issue 3, September 2026.Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley +1 more source
GSDME with a moonlighting function in pancreatic ductal adenocarcinoma: a narrative review
Journal of Pancreatology, 2022 Pancreatic ductal adenocarcinoma (PDAC) originates in the exocrine pancreas and accounts for 95% of pancreatic cancers, with 5-year survival rates of approximately 10%. Multiple factors are involved in PDAC pathogenesis, including internal genetic alterations and external inflammation-related stimuli.
openaire +2 more sources
In vivo instillation of silica induced pulmonary inflammation alleviates in Gsdmd-/-Gsdme-/- mice.
, 2022 a The number of cells in the BALF of WT, Nlrp3-/-, Caspase-1-/-, Gsdmd-/-, Gsdme-/- and Gsdmd-/-Gsdme-/- mice 14 days after exposure to PBS or silica, n = 3.
Yujie Zou (408340) +12 more
core +1 more source
Nature CommunicationsImmune checkpoint inhibitor (ICI)-induced myocarditis involves intensive immune/inflammation activation; however, its molecular basis is unclear.
Si-Jia Sun +17 more
doaj +1 more source
The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation
eLifeCaspase (CASP) is a family of proteases involved in cleavage and activation of gasdermin, the executor of pyroptosis. In humans, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME).
Hang Xu +4 more
doaj +1 more source
GSDME expression is regulated by epigenetic mechanisms in breast cancer cells.
, 2023 A and B. qRT-PCR and Western blot analysis showed GSDME expression in MCF-7 and MCF-7/Taxol cells. **PPvs control group. C. Pearson’s correlation analysis of the relative expression levels of GSDME and the relative p-GP protein expression levels in the ...
Maodong Leng (14716900) +3 more
core +1 more source