Results 81 to 90 of about 25,524 (331)

Pyroptosis, metabolism, and tumor immune microenvironment

Clinical and Translational Medicine, 2021
In response to a wide range of stimulations, host cells activate pyroptosis, a kind of inflammatory cell death which is provoked by the cytosolic sensing of danger signals and pathogen infection.
Tiantian Du, Jie Gao, Peilong Li, Yunshan Wang, Qiuchen Qi, Xiaoyan Liu, Juan Li, Chuanxin Wang, Lutao Du   +8 more
doaj   +1 more source

PD-L1-Mediated Gasdermin C Expression Switches Apoptosis to Pyroptosis in Cancer Cells and Facilitates Tumor Necrosis

Nature Cell Biology, 2020
Although pyroptosis is critical for macrophages against pathogen infection, its role and mechanism in cancer cells remains unclear. PD-L1 has been detected in the nucleus, with unknown function.
Junwei Hou, Rong-Ce Zhao, W. Xia, Chiung-Wen Chang, Y. You, Jung-Mao Hsu, L. Nie, Yeh Chen, Yu-Chuan Wang, Chunxiao Liu, Wei‐Jan Wang, Yun Wu, Baozhen Ke, J. Hsu, Ke-Bin Huang, Zu Ye, Yi Yang, Xiang-Hou Xia, Yintao Li, Chia-Wei Li, Bin Shao, J. Tainer, M. Hung   +22 more
semanticscholar   +1 more source

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Gasdermins: pore-forming activities and beyond [PDF]

Acta Biochimica et Biophysica Sinica, 2020
Gasdermins (GSDMs) belong to a protein superfamily that is found only in vertebrates and consists of GSDMA, GSDMB, GSDMC, GSDMD, DFNA5 (a.k.a. GSDME) and DFNB59 (a.k.a. Pejvakin (PJVK)) in humans. Except for DFNB59, all members of the GSDM superfamily contain a conserved two-domain structure (N-terminal and C-terminal domains) and share an ...
Zengzhang, Zheng, Wanyan, Deng, Xiwen, Lou, Yang, Bai, Junhong, Wang, Huasong, Zeng, Sitang, Gong, Xing, Liu   +7 more
openaire   +2 more sources

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

CARD domains mediate anti-phage defense in bacterial gasdermin systems

Nature
Caspase recruitment domains (CARDs) and pyrin domains are important facilitators of inflammasome activity and pyroptosis1. Following pathogen recognition by nucleotide binding-domain, leucine-rich, repeat-containing (NLR) proteins, CARDs recruit and ...
Tanita Wein, A. Millman, Katharina Lange, Erez Yirmiya, Romi Hadary, Jeremy Garb, S. Melamed, Gil Amitai, O. Dym, Felix Steinruecke, Aidan B. Hill, P. Kranzusch, R. Sorek   +12 more
semanticscholar   +1 more source

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

Cell Research, 2015
Inflammasome is an intracellular signaling complex of the innate immune system. Activation of inflammasomes promotes the secretion of interleukin 1β (IL-1β) and IL-18 and triggers pyroptosis.
Wan-ting He, H. Wan, Li-Chen Hu, Pengda Chen, Xin Wang, Zhe Huang, Zhang-Hua Yang, Chuan-Qi Zhong, Jiahuai Han   +8 more
semanticscholar   +1 more source

Pyroptosis, gasdermins and allergic diseases

Allergy
AbstractPyroptosis is an inflammatory form of programmed cell death that is distinct from necrosis and apoptosis. Pyroptosis is primarily mediated by the gasdermin family of proteins (GSDMA‐E and PVJK), which, when activated by proteolytic cleavage, form pores in the plasma membrane, leading to cell death.
Ronald Allan Panganiban, Kari C. Nadeau, Quan Lu   +2 more
openaire   +2 more sources

Gasdermin: A new player to the inflammasome game

, 2017
Pyroptosis is a lytic type of programmed cell death that was traditionally associated with the involvement of inflammatory caspases, such as caspase-1. These inflammatory caspases are activated within multi-protein complexes called inflammasomes that are
Erivan S. Ramos-Junior, Ana Carolina Morandini   +1 more
core   +1 more source

Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

Advanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang, Kaikun Yuan, Haoyu Zou, Hanfeng Qin, Jiale Liu, Jianda Sun, Feifan Zhang, Yuankui Wang, Tong Wang, Jiaxing Dai, Chunxu Li, Yichi Chen, Yingfeng Tu, Huaizhang Shi   +13 more
wiley   +1 more source