Results 81 to 90 of about 21,860 (253)

Self‐Accelerating Bimetallic Peroxide Nanozymes for Cascade‐Amplified Pyroptosis‐Immunotherapy

Advanced Science, EarlyView.
Acidic tumor microenvironment‐responsive CuZnONPs enable triple‐combination therapy via self‐supplying H2O2, cascade nanozyme activities for ROS burst, and Zn2+‐activated pyroptosis, synergizing catalytic therapy with immunotherapy to convert cold tumors into hot ones.
Xuanyi Lu, Liang Li, Siyu Pan, Yuehan Jian, Yuhan Chen, Wenjie Yang, Guang Song, Xueyang Fang, Ping'an Ma, Lijun Jiang   +9 more
wiley   +1 more source

Inflammasomes in Host Defense and Autoimmunity [PDF]

, 2016
Inflammasomes are large multi-protein complexes that control host defense and inflammation during infections with pathogens. Their clinical importance however reaches beyond infectious disease, since dysregulated inflammasome activity has also been ...
Broz, Petr
core   +2 more sources

Mass spectrometry-based proteomic exploration of the human immune system : focus on the inflammasome, global protein secretion, and T cells [PDF]

, 2017
Introduction: The immune system is our defense system against microbial infections and tissue injury, and understanding how it works in detail is essential for developing drugs for different diseases.
Cypryk, Wojciech, Lorey, Martina B., Matikainen, Sampsa, Nyman, Tuula A.   +3 more
core   +1 more source

CD44‐Targeting Hydroxyapatite Nanoparticles (HAP) Induce Mitochondrial Dysfunction‐Driven PANoptosis and Immunogenic Cell Death (ICD) via Ca Overload in Colorectal Cancer

Advanced Science, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao, Yuxuan Yang, Haosen Qiu, Jia Yang, Hao Liang, Zhaojun Jiang, Xiao Tong, Yongying Li, Qunfeng Huang, Jiaming Wu, Tian Lin, Jiang Yu, Min Liang   +12 more
wiley   +1 more source

Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma [PDF]

, 2012
Genome-wide association studies (GWAS) have identified loci reproducibly associated with pulmonary diseases; however, the molecular mechanism underlying these associations are largely unknown.
Bosse, Yohan, Brandsma, Corry-Anke, Couture, Christian, Curtis, Sean P., Daley, Denise, Derry, Jonathan M., Elliott, W. Mark, Hackett, Tillie L., Hao, Ke, Hogg, James C., Koppelman, Gerard, Kulkarni, Amit, Lamontagne, Maxime, Laviolette, Michel, Malkov, Vladislav, Nicholson, Donald W., Nickle, David C., Opiteck, Greg J., Pare, Peter D., Postma, Dirkje S., Reicin, Alise S., Sandford, Andrew, Sin, Don D., Suver, Christine, Timens, Wim, Tsou, Jeffrey A., van den Berge, Maarten, Vessey, Rupert, Zhang, Chunsheng   +28 more
core   +4 more sources

Hepatotoxicity of Nonesterified Fatty Acids to Dairy Cows: Pathophysiological Mechanisms and Prospective Solutions

Animal Research and One Health, EarlyView.
Unregulated inflammation increases non‐esterified fatty acids (NEFAs), and triggers multi‐pathway hepatocyte damage including oxidative stress, mitochondrial dysfunction, and metabolic disorders in dairy cows. ABSTRACT Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in ...
Siqing Mao, Yuan Tian, Dan Li, Lei Tian, Hang Yu, Ziling Liu, Xin Gao, Yanqiong Wen, Fachun Wan, Zuo Wang, Weijun Shen, Xinwei Li, Lei Liu   +12 more
wiley   +1 more source

Zebrafish in Inflammasome Research

Cells, 2019
Inflammasomes are cytosolic multiprotein complexes that regulate inflammatory responses to danger stimuli and infection, and their dysregulation is associated with an increasing number of autoinflammatory diseases.
Gabriel Forn-Cuní, Annemarie H. Meijer, Monica Varela   +2 more
doaj   +1 more source

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. [PDF]

, 2011
Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including ...
Abel, Rebekah A, Adkinson, N Franklin, Ampleford, Elizabeth J, Avila, Lydiana, Avila, Pedro C, Barnes, Kathleen C, Baurley, James W, Beaty, Terri H, Bleecker, Eugene R, Burchard, Esteban G, Busse, William W, Calhoun, William J, Capurso, Daniel, Castro, Mario, Celedón, Juan C, Chapela, Rocio, Childhood Asthma Management Program (CAMP), Childhood Asthma Research and Education (CARE) Network, Children's Health Study (CHS) and HARBORS study, Chiu, Grace Y, Chung, Kian Fan, Conti, David V, Deichmann, Klaus A, del Rio-Navarro, Blanca, Diette, Gregory B, Dunston, Georgia M, Eng, Celeste, Ezurum, Serpil C, Faruque, Mezbah U, Ford, Jean G, Galanter, Joshua, Gauderman, W James, Genetic Research on Asthma in African Diaspora (GRAAD) Study, Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Asthma, Genes & Environments (SAGE), Gern, James E, Gignoux, Christopher R, Gilliland, Frank D, Graves, Penelope E, Hancock, Dana B, Hansel, Nadia N, Heinzmann, Andrea, Hernandez, Ryan D, Himes, Blanca E, Hu, Donglei, Huntsman, Scott, Israel, Elliott, Lemanske, Robert F, Levin, Albert M, Li, Xia, Li, Xingnan, Liang, Liming, London, Stephanie J, Mantese, Vito J, Martinez, Fernando D, Mathias, Rasika A, Mexico City Childhood Asthma Study (MCAAS), Meyers, Deborah A, Myers, Rachel A, Nicolae, Dan L, Ober, Carole, Raby, Benjamin A, Rafaels, Nicholas, Rodriguez-Cintron, William, Rodriquez-Santana, Jose R, Romieu, Isabelle, Ross, Kevin D, Roth, Lindsey A, Ruczinski, Ingo, Salam, Muhammad T, Shi, Min, Sienra-Monge, Juan J, Soto-Quiros, Manuel, Stern, Debra A, Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE), Togias, Alkis, Torgerson, Dara G, Van Den Berg, David J, Vora, Hita, Watson, Harold R, Weiss, Scott T, Wenzel, Sally E, Williams, L Keoki   +81 more
core   +2 more sources

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids [PDF]

, 2019
Current clinical diagnosis is typically based on a combination of approaches including clinical examination of the patient, clinical experience, physiologic and/or genetic parameters, high-tech diagnostic medical imaging, and an extended list of ...
Hoste, Eric, Vanden Berghe, Tom
core   +2 more sources