Results 121 to 130 of about 25,524 (331)
Advanced Science, EarlyView.During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum +13 more
wiley +1 more source
Pyroptosis‐Inducing Biomaterials Pave the Way for Transformative Antitumor Immunotherapy
Advanced SciencePyroptosis can effectively overcome immunosuppression and reactivate antitumor immunity. However, pyroptosis initiation is challenging. First, the underlying biological mechanisms of pyroptosis are complex, and a variety of gasdermin family proteins can ...
Hao Yin +8 more
doaj +1 more source
Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis
Annual Review of Immunology, 2020 Caspases are a family of conserved cysteine proteases that play key roles in programmed cell death and inflammation. In multicellular organisms, caspases are activated via macromolecular signaling complexes that bring inactive procaspases together and ...
Sannula Kesavardhana +2 more
semanticscholar +1 more source
An ancient defense mechanism: Conservation of gasdermin-mediated pyroptosis.
, 2023 The gasdermins are a family of pore-forming proteins involved in various cellular processes such as cell death and inflammation. A new study in PLOS Biology explores the evolutionary history of gasdermins across metazoans, highlighting the conservation ...
Chengliang Wang, Jianbin Ruan
core +1 more source
Advanced Science, EarlyView.A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou +12 more
wiley +1 more source
Triggering Pyroptosis in Cancer
BiomoleculesPyroptosis is an inflammatory programmed cell death recently identified as a crucial cellular process in various diseases, including cancers. Unlike other forms of cell death, canonical pyroptosis involves the specific cleavage of gasdermin by caspase-1,
Daniel E. Johnson, Zhibin Cui
doaj +1 more source
Gasdermins: novel mitochondrial pore-forming proteins
Molecular & Cellular Oncology, 2019 Gasdermin proteins have been extensively characterized for their ability to form necrotic pores in the plasma membrane, however, their interactions with other organelles have yet to be described.
Corey Rogers, Emad S. Alnemri
doaj +1 more source
NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation
Science AdvancesGasdermin D (GSDMD) serves as a vital mediator of inflammasome-driven pyroptosis. In our study, we have identified NU6300 as a specific GSDMD inhibitor that covalently interacts with cysteine-191 of GSDMD, effectively blocking its cleavage while not ...
Xueqin Jiang +14 more
semanticscholar +1 more source
Research progress on pyroptosis regulated by mesenchymal stem cell-derived exosomes
Frontiers in ImmunologyPyroptosis is a newly discovered form of inflammatory programmed cell death, which is frequently involved in the occurrence and development of various diseases.
Tingyu Yang +6 more
doaj +1 more source
Gasdermin E dictates inflammatory responses by controlling the mode of neutrophil death
Nature CommunicationsApoptotic and lytic cell death pathways are both utilised in the removal of damaged cells; however, the downstream inflammatory outcomes widely vary according to the chosen pathway.
Fengxia Ma +11 more
semanticscholar +1 more source