Results 131 to 140 of about 17,935 (273)

Iron induces B cell pyroptosis through Tom20–Bax–caspase–gasdermin E signaling to promote inflammation post-spinal cord injury [PDF]

, 2023
Chengjie Wu, Lining Wang, Sixian Chen, Lei Shi, Mengmin Liu, Pengcheng Tu, Jie Sun, Ruihua Zhao, Yafeng Zhang, Jianwei Wang, Yalan Pan, Yong Ma, Yang Guo   +12 more
openalex   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, Volume 16, Issue 6, Page 1150-1165, June 2026.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Reinforcing Calcium Overload via Inflammation‐Mediated Targeting to Amplify Pyroptosis and Antitumor Immunity

Advanced Science, Volume 13, Issue 31, 4 June 2026.
A neutrophil‐membrane‐camouflaged nanoplatform (RC@NMVs) exploits tumor inflammation to target and accumulate in tumors. Intracellular Ca2+ overload is triggered via lysosomal CaP dissolution and Ru red‐mediated Ca2+ channel blockade, synergistically inducing gasdermin‐mediated pyroptosis.
Yingying Liu, Yang Liu, Qin Fan, Jinqiao Zhang, Kexin Wen, Boyu Yuan, Xianzhou Cai, Ziliang Dong, Lianhui Wang   +8 more
wiley   +1 more source

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 31, 4 June 2026.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source

Role of gasdermins in chronic kidney disease

Frontiers in Immunology
Gasdermins (GSDMs), functioning as membrane perforating proteins, can be activated by canonical inflammasomes, noncanonical inflammasomes, as well as non-inflammasomes, leading to cell pyroptosis and the subsequent release of inflammatory mediators.
Hanchao Gao, Ting Xie, Yunyi Li, Zigan Xu, Zhuoheng Song, Huixia Yu, Hongming Zhou, Weilong Li, Chen Yun, Baozhang Guan, Shaodong Luan, Lianghong Yin   +11 more
openaire   +3 more sources

A Cooperative Release of Mitochondrial DNA From Platelets and Neutrophils Drives an Interferon Signature in Systemic Sclerosis

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1281-1293, June 2026.
Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the role of circulating DNA in systemic sclerosis (SSc) and the cellular mechanisms governing its release.
Stavros Giaglis, André N. Tiaden, Simone Häner‐Massimi, Diego Kyburz, Cedric André, Anton Glück, Enrico Ferrero, Stuart Hawtin, Tobias Junt, Ulrich A. Walker   +9 more
wiley   +1 more source

Gasdermin D‐Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis [PDF]

C Liu, Ning Liang, Chen Wu, Zhaoyan Qiu, Qian Huang, Xiaolong Wei, Shurong Zhang, Shuanghong Lei, Tao Yang, Gang Wang, Qian Wang   +10 more
openalex   +1 more source

The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion

, 2022
Shanshan Wang, France Moreau, Kris Chadee   +2 more
openalex   +2 more sources

Traditional Respiratory Remedies From Anatolia: Ethnobotanical Insights and Bioactive Properties

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
ABSTRACT Respiratory disorders, ranging from acute viral infections such as influenza and bronchitis to chronic inflammatory conditions including chronic obstructive pulmonary disease, asthma, emphysema, and pneumonia, represent a major global health burden, affecting millions annually. Traditional Anatolian folk medicine has long relied on plant‐based
Golshan Zare, Yağmur Diker, Irem Tatlı Çankaya, Emran Habibi, Satyajit D. Sarker, Lutfun Nahar   +5 more
wiley   +1 more source

Gasdermin‐E‐Dependent Non‐Canonical Pyroptosis Promotes Drug‐Induced Liver Failure by Promoting CPS1 deISGylation and Degradation

Advanced Science
Drug‐induced liver injury (DILI) is a significant global health issue that poses high mortality and morbidity risks. One commonly observed cause of DILI is acetaminophen (APAP) overdose. GSDME is an effector protein that induces non‐canonical pyroptosis.
Shen‐Xi Ouyang, Jia‐Hui Zhu, Qi Cao, Jian Liu, Zhen Zhang, Yan Zhang, Jing‐Wen Wu, Si‐Jia Sun, Jiang‐Tao Fu, Yi‐Ting Chen, Jie Tong, Yi Liu, Jia‐Bao Zhang, Fu‐Ming Shen, Dong‐Jie Li, Pei Wang   +15 more
doaj   +1 more source