Results 131 to 140 of about 16,670 (227)

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

Gasdermin family: a promising therapeutic target for asthma. [PDF]

Front Med (Lausanne)
Wang C, Zhang X, Cheng F, Huang H, Li X.
europepmc   +1 more source

Preclinical Evaluation of Berry Extracts as a Nutritional Intervention to Alleviate Myocardial Ischemia–Reperfusion Injury and Atherosclerosis Development

Phytotherapy Research, Volume 40, Issue 8, Page 5299-5315, August 2026.
Schematic representation of the experimental design and the proposed mechanisms underlying the cardioprotective and anti‐atherosclerotic effects of Greek‐derived berry extracts. C57BL/6 mice with WD–induced MS and ApoE−/− mice with atherosclerosis received chronic supplementation with WMex or BBex.
Lydia Symeonidi, Panagiota‐Efstathia Nikolaou, Panagiotis Stathopoulos, Andriana Christodoulou, Alexandra Svouraki, Panagiotis Efentakis, Christina Chania, Angeliki Choustoulaki, Maria Xenaki, Anna Agapaki, Maria Tsoumani, Nikolaos Kostomitsopoulos, Ioulia Tseti, Gemma Vilahur, Alexios‐Leandros Skaltsounis, Ioanna Andreadou   +15 more
wiley   +1 more source

Recent Advances in the Molecular Mechanisms of Bacterial Anti‐Phage Defence Systems

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
Panoptes as an example for an antiphage system consists of OptS producing a cyclic dinucleotide that prevents activation of OptE, a transmembrane protein. Phage T4 infection introduces the sponge protein Acb2 that adsorbs the cyclic dinucleotide thus activating OptE which disrupts the cell membrane aborting phage infection.
Harald Brüssow
wiley   +1 more source

Effect of Huiyang Shengji unguent on the NOD-like receptor family pyrin domain containing protein 3/caspase1/ gasdermin D pathway and lymphatic angiogenesis in patients with diabetic foot ulcer. [PDF]

J Tradit Chin Med
Fangning YU, Li L, Xiao T, Xiujuan HE, Bo Z, Yukun C, Yizhao MA, Zeyu L, Jinsheng YE, Xuying XU.   +9 more
europepmc   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, Volume 117, Issue 8, Page 2064-2084, August 2026.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Cell death in uveitis: pyroptosis, ferroptosis, apoptosis, and beyond. [PDF]

Front Immunol
Liu J, Mao L, Chen G, Zou L, Shi Y, Jiang L, Meng J.   +6 more
europepmc   +1 more source

Die Rolle des entzündlichen Zelltods bei Typ‐1‐dominanten entzündlichen Hautkrankheiten

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 8, Page 1047-1051, August 2026.
Zusammenfassung Während es in den letzten Jahren große Fortschritte bei der Entwicklung neuer Therapien für die Psoriasis und die atopische Dermatitis gab, ist die Innovation im Bereich der Typ‐1‐dominanten Hautkrankheiten immer noch überschaubar. Zu dieser Gruppe zählt man all jene Erkrankungen, bei denen es zu einer zytotoxischen Immunreaktion gegen ...
Felix Lauffer
wiley   +1 more source

The Role of Gasdermin B-Mediated Pyroptosis in Bladder Cancer Diagnosis. [PDF]

Int J Mol Sci
Pączek S, Olkowicz M, Kudelski J, Gudowska-Sawczuk M.   +3 more
europepmc   +1 more source

Therapeutic intervention with sinomenine and irisin to preserve cardiac function after ischaemia–reperfusion injury

Experimental Physiology, Volume 111, Issue 8, Page 3557-3569, 1 August 2026.
Abstract Despite advancements in reperfusion therapy, myocardial ischaemia–reperfusion (IR) injury remains a major clinical challenge. This study investigated whether a novel dual‐target pre‐conditioning strategy using sinomenine and irisin could enhance myocardial resistance against IR injury. Ninety male Sprague–Dawley rats were utilized.
Lianjun Wu, Sining Bi, Amany Belal, Zhuzhu Liu   +3 more
wiley   +1 more source