Results 151 to 160 of about 21,860 (253)

High‐Throughput Screening Reveals That CeeNU Acts as a New NLRP3 Inflammasome Inhibitor

MedComm, Volume 7, Issue 5, May 2026.
We conducted a high‐throughput screen of 2747 FDA‐approved drugs to identify inhibitors of pyroptosis. We found that CeeNU significantly repressed NLRP3‐dependent IL‐1β release and GSDMD pore‐forming complex. We identified that the arginine 335 amino acid of the NACHT domain of NLRP3 is the critical point for human NLRP3 and CeeNU interaction and ...
Sen‐Lin Ji, Peipei Chen, Huaiping Tang, Chao Zhou, Zihao Li, Yunshu Wang, Xiang Cao, Liwen Zhu, Xinyu Bao, Zhuo Liu, Yan Chen, Yun Xu   +11 more
wiley   +1 more source

Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies

MedComm, Volume 7, Issue 5, May 2026.
Tumors are no longer viewed as sterile but dynamic ecosystems harboring low‐biomass intratumoral microbiota. These microbes, derived from gut, oral cavity, or circulation, shape tumorigenesis and therapy response via core mechanisms: immunomodulation (regulating T cells, macrophages), metabolic reprogramming (SCFAs, indoles, bile acids), chronic ...
Haoling Zhang, Zengkan Du, Ping Lu, Aimin Jiang, Yadong Guo, Yawei Liu, Zhijing Song, Bing Dai, Wangzheqi Zhang   +8 more
wiley   +1 more source

Gasdermin D and Gasdermin E Are Dispensable for Silica-Mediated IL-1β Secretion from Mouse Macrophages

ImmunoHorizons
Abstract Silica crystals activate the NLRP3 inflammasome in macrophages, resulting in the caspase-1–dependent secretion of the proinflammatory cytokine IL-1β. Caspase-1–mediated cleavage of gasdermin D (GSDMD) triggers the formation of GSDMD pores, which drive pyroptotic cell death and facilitate the rapid release of IL-1β.
Jennifer Leung, Michael Chang, Richard E Moore, Jargalsaikhan Dagvadorj, Fayyaz S Sutterwala, Suzanne L Cassel   +5 more
openaire   +2 more sources

First‐In‐Human Safety, Pharmacokinetics, and Pharmacodynamics of VENT‐02 Freebase, a CNS‐Penetrant NLRP3 Inhibitor

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT The NLRP3 inflammasome is a central mediator of innate immunity and a key driver of inflammatory and neurodegenerative diseases. VENT‐02 is orally bioavailable, central nervous system‐penetrant, selective small‐molecule inhibitor of NLRP3. This first‐in‐human, randomized, double‐blind, placebo‐controlled study assessed the safety, tolerability,
Lisanne C. A. Smidt, Matthijs Moerland, Manon A. A. Jansen, Philip H. C. Kremer, Alexandra A. J. Sille, Pamela K. Strugala, Erica S. Klaassen, Anick Auger, Silvana Jananji, Rania Faidi, Kelly A. Pike, Loraine Warner, Andre Matta, Xavier Valencia, Ofer Spiegelstein   +14 more
wiley   +1 more source

Molecular Mechanism of Caspase‐8–Dependent Interleukin‐18 Activation in Pancreatic Cancer Cells Induced by 5‐Fluorouracil and Nutrient Starvation

Genes to Cells, Volume 31, Issue 3, May 2026.
Nutrient starvation triggers pyroptosis with cleavage of pro‐IL‐18 and GSDMD in pancreatic cancer cells, and treatment of 5‐FU enhances this process. As a result, active IL‐18 is released and leads to inflammation. ABSTRACT Interleukin‐18 (IL‐18) is a pro‐inflammatory cytokine, and higher IL‐18 expression in pancreatic tumors is associated with poor ...
Hiroki Kamino, Yuko Nariai, Takeshi Urano   +2 more
wiley   +1 more source

N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting [PDF]

, 2015

core   +1 more source

Gasdermins pore cell membrane to pyroptosis [PDF]

Science China Life Sciences, 2016
Liang, Huanhuan, Liu, Yingfang
openaire   +2 more sources

Gasdermin as a Molecular Signature and Predictor of Adult-Type Diffuse Glioma Severity and Grading. [PDF]

J Clin Med
Kaczor S, Hubert K, Papuga S, Pawlak D, Harish B, Hermanowicz A, Kowalska M, Hermanowicz JM.   +7 more
europepmc   +1 more source

The killer protein Gasdermin D [PDF]

Cell Death & Differentiation, 2016
John A Wright, Clare E Bryant
openaire   +1 more source

Gasdermin E: a missing link in muscle regeneration. [PDF]

J Clin Invest
Krishna S, Rafael-Fortney JA.
europepmc   +1 more source