The expression profile of Gasdermin C-related genes predicts the prognosis and immunotherapy response of pancreatic adenocarcinoma. [PDF]
, 2023 Xiang-Hou Xia +11 more
openalex
Vacuolization as a Novel Approach to Cancer Therapy
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak +9 more
wiley +1 more source
Editorial: Gasdermins in the defense against pathogens
Frontiers in Immunology, 2023 Eckhart, Leopold, Chen, Ruochan
openaire +3 more sources
Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases
MedComm, Volume 7, Issue 6, June 2026.Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu +9 more
wiley +1 more source
eLife Assessment: The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation [PDF]
, 2023 Irene Salinas
openalex +1 more source
The Role of N6‐Methyladenosine Modification in Health and Disease
MedComm, Volume 7, Issue 6, June 2026.N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li +6 more
wiley +1 more source
The Role of Neutrophils and NETosis in Diseases: The Implications for Therapy
MedComm, Volume 7, Issue 6, June 2026.Neutrophils secrete cytokines, express specific surface proteins, increase or decrease in cell count, and their ratio to lymphocyte count can be used as biomarkers to characterize collective status and disease progression. Neutrophils can monitor and track the body's health status, “Wei Bing” status, disease status, and different times of disease ...
Zhen Ma +6 more
wiley +1 more source
Gasdermin D unlocks metabolic pathways to enhance tissue regeneration [PDF]
Quazi T.H. Shubhra
openalex +1 more source
Acute Lung Injury: From Molecular Circuits to System‐Level Therapeutics
MedComm, Volume 7, Issue 6, June 2026.This visual summary illustrates the paradigm shift from linear pathways to network medicine in ALI. Three interconnected circuits—innate immunity, immunometabolism, and cell death (PANoptosis)—drive disease progression under multiorgan crosstalk (gut–lung, brain–lung).
Yaoli Hou +10 more
wiley +1 more source