Results 161 to 170 of about 25,524 (331)

GSDME in cardiovascular diseases: research system and contemporary progress

Frontiers in Immunology
Despite considerable advancements in treatment technologies in recent years, cardiovascular diseases still pose a significant threat to human health.
Zhenzhen Yang, Zilong Luo, Han Zhang, Han Zhang, Junjie Zong, Junjie Zong, Pinyan Huang, Pinyan Huang, Yuqing Niu, Cheng Zhou, Cheng Zhou, Song Wang, Song Wang, Dan Zhang, Dan Zhang   +14 more
doaj   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, EarlyView.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

Logic “AND Gate Circuit”-Based Gasdermin Protein Expressing Nanoplatform Induces Tumor-Specific Pyroptosis to Enhance Cancer Immunotherapy

Pyroptosis mediated by gasdermin protein has shown great potential in cancer immunotherapies. However, the low expression of gasdermin proteins and the systemic toxicity of nonspecific pyroptosis limit its clinical application.
Benyu Liu (8807957), Xiaoxi Wang (130742), Xueqin Zhu (6206435), Bingyu Li (279797), Meiyi Liu (5818517), Wenyan Zhang (327993), Sijia Liu (1751842), Shixin Liao (12342127), Yongchao Wang (128812), Zixian Wu (10882656), Zhenzhen Chen (490585), Yan Wang (15435), Zimai Liu (12537456), Pingping Zhu (1746223), Chong Li (120471)   +14 more
core   +1 more source

Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen, Didem Şöhretoğlu, Ayşe Kuruüzüm‐Uz   +2 more
wiley   +1 more source

Decoding the molecular mechanisms of pyroptosis and its therapeutic development prospects

Frontiers in Cell and Developmental Biology
Pyroptosis is an emerging form of inflammatory programmed cell death primarily mediated by the gasdermin protein family, characterized by cell swelling, membrane pore formation, and the release of pro-inflammatory cytokines such as IL-1β and IL-18.
Yi Shen, Qiangqiang Zheng, Yang Yuan, Wei Chen, Min Liang, Feng Jian, Maohua Li, Yunfeng Zhou   +7 more
doaj   +1 more source

Effects of paraprobiotic Lactobacillus acidophilus LA‐5 on PANoptosis, oxidative stress and inflammation in acetic acid‐induced ulcerative colitis

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Ulcerative colitis (UC) is a relapsing inflammatory bowel disease characterised by oxidative stress, inflammation and regulated cell death of the colonic mucosa. Because live probiotics may cause bacteraemia and sepsis in immunocompromised hosts, non‐viable (paraprobiotic) alternatives have attracted interest.
Adem Yavaş, Ezgi Özkıran, Ecem Akan
wiley   +1 more source

Staphylococcus aureus induces Gasdermin A-dependent keratinocyte pyroptosis

Nature Communications
Staphylococcus aureus is a common colonizer of human skin, which, despite its ubiquitous nature, has a high virulence potential. Tolerating microbes in health but responding effectively to pathogens presents a challenge to the barrier tissues.
Doris L. LaRock, Jacob Sherman, Claire Qu, W. Ngai, Timothy D. Read, M. McGavin, Christopher N. LaRock   +6 more
semanticscholar   +1 more source

Terazosin Attenuates Neuronal Pyroptosis by Regulating the Mitochondrial ROS/NLRP3 Inflammasome Axis Through Mitophagy in Cerebral Ischemia–Reperfusion Injury

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Cerebral ischemia–reperfusion injury (CI/RI) is a major cause of secondary neuronal damage following ischemic stroke. This study investigated whether terazosin (TZ) exerts neuroprotective effects by regulating mitophagy and the reactive oxygen species (ROS)/NOD‐like receptor protein 3 (NLRP3) inflammasome axis.
Wei Wang, Xin‐Yue Han, Li‐An Huang, Yu‐Sheng Zhang, Heng Meng, An‐Ding Xu   +5 more
wiley   +1 more source

Viral protease sensing for programmable antiviral lytic cell death: The path to trials. [PDF]

Clin Transl Med
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Li L, Yan XL, Qin CF.
europepmc   +2 more sources

Investigation of Gasdermin-D and Pannexin-1 in Omental Adipose and Placental Tissues in Obese Pregnant Women [PDF]

Aim: Gasdermin-D (GSDMD) and pannexin-1 (PANX1), which are proinflammatory proteins, may be involved in the pathogenesis of complications in pregnant women with obesity.
Busra Seker Atas, Beyza Arpacı Saylar, Filiz Yarsilikal Guleroglu, Fatma Karasabanoglu, Ali Cetin, Merve Topaktas Ozbas   +5 more
core   +1 more source