Results 141 to 150 of about 17,935 (273)
Programmed Cell Death in Chronic Rhinosinusitis
ABSTRACT Chronic rhinosinusitis (CRS) is a prevalent upper respiratory condition characterized by a multifaceted etiology involving various cellular and molecular processes. In recent years, researchers have increasingly recognized the significance of different forms of programmed cell death (PCD), such as apoptosis and pyroptosis, in the pathological ...
Xingchen Liu +5 more
wiley +1 more source
This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni +3 more
wiley +1 more source
The Supporting Role of Natural Products as Effective Adjuvants in Cancer Immunotherapy
Natural products, as multi‐target and low‐toxicity adjuvants, enhance immune checkpoint inhibitor responses and reduce immune‐related adverse events through T cell reprogramming, microenvironment remodeling, and microbiota‐immune modulation. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of malignant tumors ...
Boyang Liu +6 more
wiley +1 more source
Mechanistic Insights into Gasdermin Pore Formation and Regulation in Pyroptosis
Chengliang Wang, Jianbin Ruan
openalex +2 more sources
RHF improves sex hormone secretion imbalance, restores the estrous cycle, inhibits ovarian hyperplasia and pathology, and reduces systemic and local ovarian inflammation in PCOS rats via enhancing HPO axis function and suppressing NLRP3 inflammasome signaling pathway activation.
Mengfan Peng +7 more
wiley +1 more source
ABSTRACT Background and Aims Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and cell differentiation.
Kajal Kamra +7 more
wiley +1 more source
Novel pyroptosis-independent functions of gasdermins
Ziran Qin, Fangfang Zhou, Long Zhang
openaire +3 more sources
TCM‐Guided Targeted Therapies Against NLRP3 Inflammasome in NAFLD
This graphical abstract illustrates TCM syndrome differentiation‐guided targeted strategies against NLRP3 inflammasome‐mediated non‐alcoholic fatty liver disease (NAFLD). Metabolic dysfunction and gut‐liver axis dysregulation drive NAFLD progression, activating the NLRP3 inflammasome (comprising NLRP3, ASC, caspase‐1) to trigger cytokine release (IL‐1β,
Yanxia Zhang
wiley +1 more source
Figure S6 from <i>In Situ</i> Delivery of Gasdermin E mRNA Promotes Antitumor Immunity via Creatine-Elicited Type I Interferon Signaling in Monocytes [PDF]
Hanjun Li +9 more
openalex +1 more source

