Results 181 to 190 of about 16,670 (227)
OxLDL-induced ferroptosis and pyroptosis in atherosclerosis: a mini review. [PDF]
Front ImmunolLiu S, Wu Y, Chen L, Hu L, Yin J.
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Inhibition of gasdermin D attenuates neutrophil extracellular trap formation induced by platelet-derived exosome in necrotizing enterocolitis. [PDF]
Cell Commun SignalZhang Y +6 more
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Structural basis and regulation of GSDME pore formation. [PDF]
Nat CommunTeran E +7 more
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Gasdermin and Gasdermin-Like Pore-Forming Proteins in Invertebrates, Fungi and Bacteria
Journal of Molecular Biology, 2022The gasdermin family of pore-forming proteins (PFPs) has recently emerged as key molecular players controlling immune-related cell death in mammals. Characterized mammalian gasdermins are activated through proteolytic cleavage by caspases or serine proteases, which remove an inhibitory carboxy-terminal domain, allowing the pore-formation process ...
N Louise Glass, Asen Daskalov
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Seminars in Immunology, 2023
The identification of gasdermin as the executor of pyroptosis has opened new avenues for the study of this process. Although pyroptosis research has mainly focused on immune cells since it was discovered three decades ago, accumulating evidence suggests that pyroptosis plays crucial roles in many biological processes.
Junwei Hou +4 more
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The identification of gasdermin as the executor of pyroptosis has opened new avenues for the study of this process. Although pyroptosis research has mainly focused on immune cells since it was discovered three decades ago, accumulating evidence suggests that pyroptosis plays crucial roles in many biological processes.
Junwei Hou +4 more
openaire +2 more sources
Gasdermins and pyroptosis in the kidney
Nature Reviews Nephrology, 2023Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1- and inflammasome-dependent cell death pathway typified by the loss of membrane integrity and the secretion of cytokines such as IL-1β.
Esteban E. Elias +2 more
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Determination of Gasdermin Pores
2023The gasdermin family represents a type of membrane pore-forming proteins. The gasdermin family is extensively characterized as the executioner of pyroptotic cell death in mammals; recent studies suggest that gasdermin-like pore-forming proteins are also present in bacteria and fungi.
Kun, Wang, Jingjin, Ding, Feng, Shao
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Mechanisms of Gasdermin Recognition by Proteases
Journal of Molecular Biology, 2022Members of the gasdermin family contain positively charged N-terminal domains (NTDs) capable of binding phospholipids and assembling membrane pores, and C-terminal domains (CTDs) that bind the NTDs to prevent pore formation in the resting states. The flexible NTD-CTD linker regions of gasdermins are highly variable in length and sequences, which may be
Tsan Xiao
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Inflammasome and gasdermin signaling in neutrophils
Molecular Microbiology, 2022AbstractInflammasomes and gasdermins mount potent host defense pathways against invading microbial pathogens, however, dysregulation in these pathways can drive a variety of inflammatory disorders. Neutrophils, historically regarded as effector phagocytes that drive host defense via microbial killing, are now emerging as critical drivers of immunity in
See Jie Yow +2 more
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Transcriptional and Epigenetic Regulation of Gasdermins
Journal of Molecular Biology, 2022Gasdermins (GSDM) are a family of six homologous proteins (GSDMA to E and Pejvakin) in humans. GSDMA-E are pore-forming proteins targeting the plasma membrane to trigger a rapid cell death termed pyroptosis or bacterial membranes to promote antibacterial immune defenses.
Emilie, Bourdonnay, Thomas, Henry
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