Results 181 to 190 of about 17,935 (273)

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection [PDF]

, 2018
Joseph Sarhan, Beiyun C. Liu, Hayley I. Muendlein, Peng Li, Rachael Nilson, Amy Y. Tang, Anthony Rongvaux, Stephen C. Bunnell, Feng Shao, Douglas R. Green, Alexander Poltorak   +10 more
openalex   +1 more source

TREM‐1 Blockade Inhibits Inflammasome Activation and Pyroptosis: Novel Insights on the Role of TREM‐1 and Syk in Monosodium Urate Crystal‐Induced Inflammation

Immunology, Volume 178, Issue 2, Page 249-260, June 2026.
Schematic overview of the roles triggering receptor expressed on myeloid cells‐1 (TREM‐1) plays in monosodium urate (MSU) crystal‐induced inflammasome activation and IL‐1β secretion in gout arthritis. The present study provides novel data suggesting that blockade of TREM‐1 by LP17 attenuates MSU‐crystal‐induced inflammation through inhibition of ...
Yair Molad, Irina Lagovsky, Vitaly Kliminski   +2 more
wiley   +1 more source

Knockdown of Gasdermin D protects hippocampal neurons by regulating both pyroptosis and ferroptosis in a rat model of status epilepticus. [PDF]

Acta Epileptol
Feng F, Wang H, Tian Y, Luo R, Cai Q.
europepmc   +1 more source

The macrophage-associated microRNA-4715-3p / Gasdermin D axis potentially indicates fibrosis progression in nonalcoholic fatty liver disease: evidence from transcriptome and biological data

, 2022
Shuai Chen, Xiurong Cai, Yu Liu, Yu Shen, Adrien Guillot, Frank Tacke, Liming Tang, Hanyang Liu   +7 more
openalex   +1 more source

Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease

Immunology, Volume 178, Issue 2, Page 218-230, June 2026.
This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley   +1 more source

Pan-cancer multi-omics profiling of gasdermins identifies GSDMD as an immune-related prognostic biomarker in kidney renal clear cell carcinoma. [PDF]

Discov Oncol
Liu Y, Li X, Chen H, Mei N, Niu L, Li Y, Liu X, Jiang X, Zhang H.   +8 more
europepmc   +1 more source

Gasdermin D-mediated neutrophil pyroptosis drives inflammation in psoriasis

J. Liu, Yuying Jiang, ZiYue Diao, DanDan Chen, RuiYuan Xia, BingWei Wang, Shuo Yang, Zhiqiang Yin   +7 more
openalex   +1 more source

Chemical Hypoxia Induces Pyroptosis in Neuronal Cells by Caspase-Dependent Gasdermin Activation [PDF]

Chan Ho Park, Jun Young Park, Won Gil Cho   +2 more
openalex   +1 more source

Tumour Necrosis Factor‐α Promotes Pyroptosis in Diabetic Liver Injury via the HMGB1/TLR4/MyD88/NF‐κB Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Diabetic liver injury (DLI) is a serious inflammatory complication, with tumour necrosis factor‐alpha (TNF‐α) recognized as a key pro‐inflammatory cytokine. This study aimed to investigate the protective effect of TNF‐α inhibition on DLI and to elucidate the underlying molecular mechanisms, focusing on the novel role of pyroptosis.
Dayin Chen, Jiajun Cheng, Bin Ni, Ruixin Zhu, Wei Wu, Minghui Zhang, Yihe Cao, Zhimei Jiang, Hongyu Sui   +8 more
wiley   +1 more source

Unraveling the complexity of pyroptosis in esophageal cancer: from underlying mechanisms to targeted therapies. [PDF]

Cancer Cell Int
Yang W, Wen J, Tang L, Zhan M.
europepmc   +1 more source