Results 201 to 210 of about 16,670 (227)
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Gasdermin D opens the way for NETs
Nature Reviews Rheumatology, 2018Gasdermin D is a pore-forming protein that can cause pyroptosis, a form of inflammatory cell death. New research indicates that the pores generated by gasdermin D can also promote the formation of neutrophil extracellular traps, potentially opening new therapeutic avenues for the treatment of inflammatory diseases.
Lotte Spel, Fabio Martinon
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Versatility of gasdermin D beyond pyroptosis
Trends in Cell BiologyGasdermin D (GSDMD) has garnered significant attention primarily for the pore-forming role of its p30 N-terminal fragment (NT-p30) generated during pyroptosis, a proinflammatory form of cell death. However, emerging evidence suggests that the formation of GSDMD-NT pores is reversible, and the activation of GSDMD does not necessarily lead to pyroptosis.
Tianming Zhao, Zhexu Chi, Di Wang
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Mechanistic insights into gasdermin-mediated pyroptosis
Nature Reviews Molecular Cell BiologyPyroptosis, a novel mode of inflammatory cell death, is executed by membrane pore-forming gasdermin (GSDM) family members in response to extracellular or intracellular injury cues and is characterized by a ballooning cell morphology, plasma membrane rupture and the release of inflammatory mediators such as interleukin-1β (IL-1β), IL-18 and high ...
Yang Bai, Youdong Pan, Xing Liu
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Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
Cell, 2021Iva Hafner Bratković +2 more
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Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine
Cell, 2023Zheng Wei, Richard Flavell
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Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases
Cell Reports, 2021Derek Abbott, Bowen Zhou
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Mechanistic Insights into Gasdermin Pore Formation and Regulation in Pyroptosis
Journal of Molecular Biology, 2022Chengliang Wang, Jianbin Ruan
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Chemical modulation of gasdermin D activity: Therapeutic implications and consequences
Seminars in Immunology, 2023Derek Abbott, Bowen Zhou
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