Results 191 to 200 of about 25,524 (331)

Itgb1‐Mediated Stabilization of Vimentin Alleviates Excessive Mechanical Stress‐Induced Nucleus Pulposus Cell Pyroptosis and Intervertebral Disc Degeneration via PINK1‐Parkin‐Dependent Mitophagy

Cell Proliferation, EarlyView.
Excessive mechanical stress induces nucleus pulposus cell pyroptosis and intervertebral disc degeneration. Itgb1 inhibits MNAT1‐mediated ubiquitination and degradation of Vimentin. Vimentin alleviates excessive mechanical stress‐induced nucleus pulposus cell pyroptosis and intervertebral disc degeneration through PINK1‐Parkin‐dependent mitophagy ...
Xuening Liu, Fengguang Yang, Yanni Duan, Hefang Xiao, Zhenyu Cao, Zhaoheng Wang, Haijun Zhang, Xuewen Kang   +7 more
wiley   +1 more source

Modified frailty index predicts programmed cell death activation and sepsis risk after total hip arthroplasty: a retrospective cohort study. [PDF]

Front Cell Dev Biol
Wei Y, Xu S, Yang M.
europepmc   +1 more source

Myo1g Mediates NKR‐P1C Expression in Primary Mouse NK Cells and Participates in Cytotoxicity

Immunology, EarlyView.
In this study we analysed the participation of Myosin 1g in the development and functions of murine natural killer (NK) cells; we found that Myosin 1g is expressed in murine‐activated primary NK cells from the spleen. Additionally, in the absence of Myosin 1g, correlates with a reduced expression of NKR‐P1C but not of CD49b or NKp46.
Héctor Romero‐Ramírez, Vania Aminta Zuleica López‐Esparza, Mariana Flores‐Castelán, Leopoldo Santos‐Argumedo   +3 more
wiley   +1 more source

Endoplasmic Reticulum Stress-Induced Endothelial Cell Pyroptosis Contributes to Pulmonary Vascular Remodeling and Pulmonary Arterial Hypertension via IRE1α/Caspase-3/GSDME Pathway. [PDF]

J Am Heart Assoc
Luo XY, Li XC, Fu X, Tian YY, Li XY, Zhang Z, Chen AF.   +6 more
europepmc   +1 more source

Phloridzin Mitigates Aging‐Associated Periodontitis by Restraining Inflammatory Cell Death

Journal of Periodontal Research, EarlyView.
Phloridzin attenuated oxidative stressinduced senescence, inflammatory responses, and osteogenic dysfunction in HPDLCs. In an aging‐associated experimental periodontitis model, phloridzin alleviated alveolar bone loss, suggesting its potential to maintain periodontal tissue integrity under aging‐related inflammatory conditions.
Da Eun Lee, Eun‐Nam Kim, Gil‐Saeng Jeong   +2 more
wiley   +1 more source

LRIG2 suppresses NK cell-induced GSDME-mediated pyroptosis via the LAMP1-STAT3 pathway in glioma. [PDF]

J Immunother Cancer
Hou X, Lin L, Zhang P, Li Y, Dong M, Chen S, Oyang X, Wang J, Cheng F, Li X, Zhao M, Mao F, Yu X, Hu D, Wang B, Guo D.   +15 more
europepmc   +1 more source

Novel pyroptosis-independent functions of gasdermins

Signal Transduction and Targeted Therapy, 2022
Ziran Qin, Fangfang Zhou, Long Zhang
openaire   +3 more sources

Theme and variations: activation and regulation of gasdermin-mediated inflammation. [PDF]

Biochem Soc Trans
Rothera EY, Horam S, Hu Y, Lin SA, David AJ, Xiao TS.   +5 more
europepmc   +1 more source

Gasdermins pore cell membrane to pyroptosis [PDF]

Science China Life Sciences, 2016
Liang, Huanhuan, Liu, Yingfang
openaire   +2 more sources

Gasdermin E is dispensable for H1N1 influenza virus pathogenesis in mice

Targeting cell death pathways, including pyroptosis and necroptosis, has been shown to mitigate influenza virus infection severity. Here, we examined whether pyroptosis specifically driven by the pore-forming protein gasdermin E (GSDME) is involved in ...
Matthew McFadden, Liu, Benjamin D., Papa, Jonathan, Speaks, Samuel, Benjamin D. Liu, Roettger, Jack E., Steve Leumi, Forero, Adriana, Yount, Jacob S., McFadden, Matthew, Jack E. Roettger, Shreenath Mohan, Brendan M. Reznik, Cable, Jana M., Samuel Speaks, Reznik, Brendan M., Leumi, Steve, Jana M. Cable, Mohan, Shreenath, Adriana Forero, Jacob S. Yount, Jonathan Papa   +21 more
core   +1 more source