Results 51 to 60 of about 21,860 (253)
Not sorcery after all: Roles of multiple charged residues in membrane insertion of gasdermin-A3
Frontiers in Cell and Developmental Biology, 2022 Gasdermins execute programmatory cell death, known as pyroptosis, by forming medium-sized membrane pores. Recently, the molecular structure of those pores as well as the diversity in their shape and size have been revealed by cryoTEM and atomic force ...
Viktoria Korn, Kristyna Pluhackova
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Gasdermins deliver a deadly punch to cancer [PDF]
Cell Research, 2020 The pore-forming gasdermin proteins mediate a lytic and proinflammatory form of cell death called pyroptosis and have been linked to the host defense against infection. Two recent studies published in Nature revealed that induction of pyroptosis in tumor cells promotes anti-tumor activity, highlighting gasdermins as potential new targets in cancer ...
Cheng Shen, Abhimanu Pandey, Si Ming Man
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Caspase-5: Structure, Pro-Inflammatory Activity and Evolution
BiomoleculesCaspase-5 is a protease that induces inflammation in response to lipopolysaccharide (LPS), a component of the cell envelope of Gram-negative bacteria. The expression level of the CASP5 gene is very low in the basal state, but strongly increases in the ...
Leopold Eckhart, Heinz Fischer
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The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. [PDF]
, 2016 Published onlineJournal ArticleResearch Support, Non-U.S. Gov'tBACKGROUND: Many genetic variants have been associated with susceptibility to complex traits by genome wide association studies (GWAS), but for most, causal genes and mechanisms of action ...
Frayling, Timothy M. +7 more
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Vastly different energy landscapes of the membrane insertions of monomeric gasdermin D and A3
Communications ChemistryGasdermin D and gasdermin A3 belong to the same family of pore-forming proteins and executors of pyroptosis, a form of programmed cell death. To unveil the process of their pore formation, we examine the energy landscapes upon insertion of the gasdermin ...
Viktoria Korn, Kristyna Pluhackova
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Gasdermins in Apoptosis: New players in an Old Game. [PDF]
, 2019 Apoptosis is a form of programmed cell death (PCD) that plays critical physiological roles in removing superfluous or dangerous cell populations that are unneeded or threatening to the health of the host organism.
Alnemri, Emad S., Rogers, Corey
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P2X7 receptor-mediated TG2 externalization: a link to inflammatory arthritis? [PDF]
, 2016 Transglutaminases have important roles in stabilizing extracellular protein assemblies in tissue repair processes but some reaction products can stimulate immune activation, leading to chronic inflammatory conditions or autoimmunity.
Aeschlimann, Daniel, Knauper, Vera
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FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
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Frontiers in ImmunologyThe gasdermin protein family and its homologs in microorganisms have gained significant attention due to their roles in programmed cell death, immune defense, and microbial infection.
Shule Wang +6 more
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The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin
mBio, 2019 The cholesterol-dependent cytolysin (CDC) genes are present in bacterial species that span terrestrial, vertebrate, and invertebrate niches, which suggests that they have evolved to function under widely different environmental conditions.
Kristin R. Wade +10 more
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