Evolution of the gasdermin family and pyroptosis
Developmental & Comparative Immunology, 2023 Gasdermins have been identified as playing a prominent role in the innate immune response as the executors of a specific type of cell death called pyroptosis. Specific proteolytic cleavage of gasdermins generates an N-terminal that oligomerizes and forms pores in the cell membrane.
Angosto-Bazarra, Diego +2 more
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Not sorcery after all : roles of multiple charged residues in membrane insertion of gasdermin-A3 [PDF]
, 2023 Gasdermins execute programmatory cell death, known as pyroptosis, by forming medium-sized membrane pores. Recently, the molecular structure of those pores as well as the diversity in their shape and size have been revealed by cryoTEM and atomic force ...
Korn, Viktoria, Pluhackova, Kristyna
core +1 more source
Gasdermin D: A potential mediator and prognostic marker of bladder cancer
Frontiers in Molecular Biosciences, 2022 Background: Bladder cancer is considered one of the commonest widespread cancers, its presentation ranges from non-muscle invasive form to being muscle-invasive. The gasdermin family of proteins consists of six proteins.
Randa El-Gamal +6 more
doaj +1 more source
Inflammasome - activated gasdermin D causes pyroptosis by forming membrane pores
Nature, 2016 Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to microbial infection and danger signals. When activated, they cleave mouse and human gasdermin D (GSDMD) after Asp276 and Asp275, respectively, to generate an N-terminal cleavage
Xing Liu +6 more
semanticscholar +1 more source
Gasdermin D pore structure reveals preferential release of mature interleukin-1
Nature, 2021 As organelles of the innate immune system, inflammasomes activate caspase-1 and other inflammatory caspases that cleave gasdermin D (GSDMD). Caspase-1 also cleaves inactive precursors of the interleukin (IL)-1 family to generate mature cytokines such as ...
S. Xia +12 more
semanticscholar +1 more source
Gasdermin E 매개 칼슘 이온이 세포고사 엑소좀 생합성에 미치는 영향
, 2023 MasterⅠ. 서론 1 Ⅱ. 재료 및 방법 9 A. 세포, 항체 9 B. PCR and In-fusion 클로닝 9 C. Lentiviral vector 형질주입 10 D. CRISPR / Cas9 녹아웃 10 E. PiggyBac transposon system 11 F. 웨스턴 블롯 12 G. Calcium fluorescence luminometer 13 H.
강, 대욱
core +1 more source
Sublytic gasdermin-D pores captured in atomistic molecular simulations
eLife, 2022 Gasdermin-D (GSDMD) is the ultimate effector of pyroptosis, a form of programmed cell death associated with pathogen invasion and inflammation. After proteolytic cleavage by caspases, the GSDMD N-terminal domain (GSDMDNT) assembles on the inner leaflet ...
Stefan L Schaefer, Gerhard Hummer
doaj +1 more source
Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis
Cell, 2022 SUMMARY Although mutations in mitochondrial-associated genes are linked to inflammation and susceptibility to infection, their mechanistic contributions to immune outcomes remain ill-defined.
C. Weindel +16 more
semanticscholar +1 more source
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
Nature Immunology, 2020 Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells assembles large complexes called inflammasomes, which activate inflammatory caspases to process cytokines (IL-1β) and gasdermin D (GSDMD).
J. Hu +17 more
semanticscholar +1 more source
‘Hints’ in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death [PDF]
Cell Death & Differentiation, 2017 Pyroptosis is a lytic form of cell death distinguished from apoptosis, ferroptosis, necrosis, necroptosis, NETosis, oncosis, pyronecrosis and autophagy. Proinflammatory caspases cleave a gasdermin D (GSDMD) protein to generate a 31 kDa N-terminal domain.
Qiu, Shiqiao, Liu, Jing, Xing, Feiyue
openaire +2 more sources