Results 51 to 60 of about 17,935 (273)
Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury
Biomolecules, 2022 Ischemia-reperfusion (I/R) injury, uncommon among patients suffering from myocardial infarction, stroke, or acute kidney injury, can result in cell death and organ dysfunction.
Yu Zheng +3 more
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Targeting gasdermin E in neurodegenerative diseases
Cell Reports Medicine, 2023 Neel et al. identified pathophysiologic clues linking gasdermin-E (GSDME) with frontotemporal dementia and amyotrophic lateral sclerosis.1 Therapeutic studies targeting GSDME may provide a viable approach for neurodegenerative diseases.
Zhou, Zhi Dong +2 more
openaire +2 more sources
Not sorcery after all: Roles of multiple charged residues in membrane insertion of gasdermin-A3
Frontiers in Cell and Developmental Biology, 2022 Gasdermins execute programmatory cell death, known as pyroptosis, by forming medium-sized membrane pores. Recently, the molecular structure of those pores as well as the diversity in their shape and size have been revealed by cryoTEM and atomic force ...
Viktoria Korn, Kristyna Pluhackova
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Gasdermins, Executors of Pyroptosis: A Decade in Perspective
Annual Review of Pathology: Mechanisms of DiseasePyroptosis is a molecularly defined pathway of cell death and lysis relying on formation of membrane pores by the family of gasdermin proteins. Since the characterization of prototypical gasdermin D in 2015, intense effort in the past decade has shed light on protease-dependent activation of these agents of cellular demise in human health and disease ...
Bowen Zhou, Derek W. Abbott
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Caspase-5: Structure, Pro-Inflammatory Activity and Evolution
BiomoleculesCaspase-5 is a protease that induces inflammation in response to lipopolysaccharide (LPS), a component of the cell envelope of Gram-negative bacteria. The expression level of the CASP5 gene is very low in the basal state, but strongly increases in the ...
Leopold Eckhart, Heinz Fischer
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The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Vastly different energy landscapes of the membrane insertions of monomeric gasdermin D and A3
Communications ChemistryGasdermin D and gasdermin A3 belong to the same family of pore-forming proteins and executors of pyroptosis, a form of programmed cell death. To unveil the process of their pore formation, we examine the energy landscapes upon insertion of the gasdermin ...
Viktoria Korn, Kristyna Pluhackova
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Self‐assembled, scaffold‐free full‐thickness skin equivalents with monoclonal, genetically modified N/TERT‐1 keratinocytes represent a novel in vitro model of human skin and skin diseases. The model is highly robust, reproducible, physiologically relevant, and suitable for high‐throughput applications.
Marta Slaufova +4 more
wiley +1 more source
Frontiers in ImmunologyThe gasdermin protein family and its homologs in microorganisms have gained significant attention due to their roles in programmed cell death, immune defense, and microbial infection.
Shule Wang +6 more
doaj +1 more source
The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin
mBio, 2019 The cholesterol-dependent cytolysin (CDC) genes are present in bacterial species that span terrestrial, vertebrate, and invertebrate niches, which suggests that they have evolved to function under widely different environmental conditions.
Kristin R. Wade +10 more
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