Results 31 to 40 of about 21,414 (253)
Role of pyroptosis in the pathogenesis and treatment of diseases
MedComm, 2023 Programmed cell death (PCD) is regarded as a pathological form of cell death with an intracellular program mediated, which plays a pivotal role in maintaining homeostasis and embryonic development.
Xiangyu Jin +3 more
doaj +1 more source
Pyroptosis and Sarcopenia: Frontier Perspective of Disease Mechanism
Cells, 2022 With global ageing, sarcopenia, as an age-related disease, has brought a heavy burden to individuals and society. Increasing attention has been given to further exploring the morbidity mechanism and intervention measures for sarcopenia.
Hongfu Jin +5 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundDuchenne muscular dystrophy (DMD) is the most common inherited human myopathy. Typically, the secondary process involving severe inflammation and necrosis exacerbate disease progression.
Nicolas Dubuisson +9 more
doaj +1 more source
Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors
eLife, 2022 The type VI secretion system (T6SS) is used by bacteria to deliver toxic effectors directly into target cells. Most T6SSs mediate antibacterial activities, whereas the potential anti-eukaryotic role of T6SS remains understudied.
Hadar Cohen +5 more
doaj +1 more source
Pyroptosis: Role and Mechanisms in Cardiovascular Disease
Frontiers in Cardiovascular Medicine, 2022 Cardiovascular disease (CVD) is a common disease that poses a huge threat to human health. Irreversible cardiac damage due to cardiomyocyte death and lack of regenerative capacity under stressful conditions, ultimately leading to impaired cardiac ...
Xinzhe Chen +4 more
doaj +1 more source
Gasdermin D: A potential mediator and prognostic marker of bladder cancer
Frontiers in Molecular Biosciences, 2022 Background: Bladder cancer is considered one of the commonest widespread cancers, its presentation ranges from non-muscle invasive form to being muscle-invasive. The gasdermin family of proteins consists of six proteins.
Randa El-Gamal +6 more
doaj +1 more source
Gasdermin-B (GSDMB) takes center stage in antibacterial defense, inflammatory diseases, and cancer [PDF]
, 2023 One of the hottest topics in biomedical research is to decipher the functional implications of the Gasdermin (GSDM) protein family in human pathologies.
Colomo del Pino, Sara +4 more
core +1 more source
Sublytic gasdermin-D pores captured in atomistic molecular simulations
eLife, 2022 Gasdermin-D (GSDMD) is the ultimate effector of pyroptosis, a form of programmed cell death associated with pathogen invasion and inflammation. After proteolytic cleavage by caspases, the GSDMD N-terminal domain (GSDMDNT) assembles on the inner leaflet ...
Stefan L Schaefer, Gerhard Hummer
doaj +1 more source
Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis
, 2020 Inflammasome-activated caspase-1 cleaves gasdermin D to unmask its pore-forming activity, the predominant consequence of which is pyroptosis. Here, we report an additional biological role for gasdermin D in limiting cytosolic DNA surveillance.
Sarkar, Saumendra N. +11 more
core +1 more source
The Role of Gasdermin-D-Mediated Pryoptosis in Organ Injury and Its Therapeutic Implications
, 2023 Gasdermin-D (GSDMD) belongs to the Gasdermin family (GSDM), which are pore-forming effector proteins that facilitate inflammatory cell death, also known as pyroptosis.
Joud Mulla +5 more
core +1 more source