Pyroptosis: Role and Mechanisms in Cardiovascular Disease
Frontiers in Cardiovascular Medicine, 2022 Cardiovascular disease (CVD) is a common disease that poses a huge threat to human health. Irreversible cardiac damage due to cardiomyocyte death and lack of regenerative capacity under stressful conditions, ultimately leading to impaired cardiac ...
Xinzhe Chen +4 more
doaj +1 more source
Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]
, 2019 For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Alonso Bellido, Isabel María +3 more
core +1 more source
The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. [PDF]
, 2018 Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome ...
Alnemri, Emad S. +9 more
core +4 more sources
Recombinant DnaK orally administered protects axenic European sea bass against vibriosis [PDF]
, 2020 Vibrio anguillarum causes high mortality in European sea bass (Dicentrarchus labrax) larviculture and is a hindering factor for successful sustainable aquaculture of this commercially valuable species.
Bajek, Aline +6 more
core +2 more sources
Targeting gasdermin E in neurodegenerative diseases
Cell Reports Medicine, 2023 Neel et al. identified pathophysiologic clues linking gasdermin-E (GSDME) with frontotemporal dementia and amyotrophic lateral sclerosis.1 Therapeutic studies targeting GSDME may provide a viable approach for neurodegenerative diseases.
Zhou, Zhi Dong +2 more
openaire +2 more sources
Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death [PDF]
, 2016 Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β.
Alix, E +7 more
core +1 more source
Gasdermin D: A potential mediator and prognostic marker of bladder cancer
Frontiers in Molecular Biosciences, 2022 Background: Bladder cancer is considered one of the commonest widespread cancers, its presentation ranges from non-muscle invasive form to being muscle-invasive. The gasdermin family of proteins consists of six proteins.
Randa El-Gamal +6 more
doaj +1 more source
Gasdermin-B promotes invasion and metastasis in breast cancer cells [PDF]
, 2014 Gasdermin B (GSDMB) belongs to the Gasdermin protein family that comprises four members (GSDMA-D). Gasdermin B expression has been detected in some tumor types such as hepatocarcinomas, gastric and cervix cancers; and its overexpression has been related ...
Abril, Sandra +11 more
core +4 more sources
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. [PDF]
, 2017 Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis.
Alnemri, Diana +5 more
core +2 more sources
Sublytic gasdermin-D pores captured in atomistic molecular simulations
eLife, 2022 Gasdermin-D (GSDMD) is the ultimate effector of pyroptosis, a form of programmed cell death associated with pathogen invasion and inflammation. After proteolytic cleavage by caspases, the GSDMD N-terminal domain (GSDMDNT) assembles on the inner leaflet ...
Stefan L Schaefer, Gerhard Hummer
doaj +1 more source