Results 11 to 20 of about 25,524 (331)
Vastly different energy landscapes of the membrane insertions of monomeric gasdermin D and A3
Communications ChemistryGasdermin D and gasdermin A3 belong to the same family of pore-forming proteins and executors of pyroptosis, a form of programmed cell death. To unveil the process of their pore formation, we examine the energy landscapes upon insertion of the gasdermin ...
Viktoria Korn, Kristyna Pluhackova
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on GSDMA (gasdermin A), with data on DNA, on the protein encoded, and where the gene is implicated.
Saeki, N, Sasaki, H
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BMC Biology, 2022 Background Gasdermins are ancient (>500million-years-ago) proteins, constituting a family of pore-forming proteins that allow the release of intracellular content including proinflammatory cytokines.
Diego Angosto-Bazarra +5 more
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Unconventional protein secretion by gasdermin pores [PDF]
Seminars in Immunology, 2023 Unconventional protein secretion (UPS) allows the release of specific leaderless proteins independently of the classical endoplasmic reticulum (ER)-Golgi secretory pathway. While it remains one of the least understood mechanisms in cell biology, UPS plays an essential role in immunity as it controls the release of the IL-1 family of cytokines, which ...
Broz, P., Petr Broz
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The Versatile Gasdermin Family: Their Function and Roles in Diseases
Frontiers in Immunology, 2021 The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess a C-terminal repressor domain, cytotoxic N-terminal domain, and flexible linker domain (except ...
Ruochan Chen, Daolin Tang
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on GSDMB (gasdermin B), with data on DNA, on the protein encoded, and where the gene is implicated.
Tamura, M, Shiroishi, T
openaire +4 more sources
Acta Pharmaceutica Sinica B, 2021 Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to induce strong inflammatory responses that defend the host against microbe infection.
Brandon E. Burdette +3 more
semanticscholar +4 more sources
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
Cell, 2021 Summary The process of pyroptosis is mediated by inflammasomes and a downstream effector known as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N-terminal domain of GSDMD forms membrane pores that promote cytolysis. Numerous
Iva Hafner Bratković +2 more
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Delving into pyroptosis in atherosclerosis: role, mechanisms and therapeutic opportunities [PDF]
Frontiers in ImmunologyAtherosclerosis is a chronic inflammatory condition that represents the primary culprit of multiple cardiovascular diseases. Pyroptosis is a modality of programmed cell death that is elicited by, and can in return amplify, inflammatory reactions, and ...
Huifang Hou +18 more
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The Paradoxical Role of Pyroptosis in Gastrointestinal Cancers: From Molecular Mechanisms to Therapeutic Horizons [PDF]
BiomedicinesPyroptosis, a gasdermin-mediated and highly immunogenic form of regulated cell death, has surfaced as a critical determinant in the progression and therapeutic landscape of gastrointestinal (GI) cancers.
John K. Triantafillidis
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