Results 11 to 20 of about 17,935 (273)
Sublytic gasdermin-D pores captured in atomistic molecular simulations [PDF]
eLife, 2022 Gasdermin-D (GSDMD) is the ultimate effector of pyroptosis, a form of programmed cell death associated with pathogen invasion and inflammation. After proteolytic cleavage by caspases, the GSDMD N-terminal domain (GSDMDNT) assembles on the inner leaflet ...
Stefan L Schaefer, Gerhard Hummer
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Frontiers in Immunology, 2023 Sepsis is a hyper-heterogeneous syndrome in which the systemic inflammatory response persists throughout the course of the disease and the inflammatory and immune responses are dynamically altered at different pathogenic stages.
Wenhua Wang, Zhihui He, Zhihui He
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The Paradoxical Role of Pyroptosis in Gastrointestinal Cancers: From Molecular Mechanisms to Therapeutic Horizons. [PDF]
BiomedicinesPyroptosis, a gasdermin-mediated and highly immunogenic form of regulated cell death, has surfaced as a critical determinant in the progression and therapeutic landscape of gastrointestinal (GI) cancers.
Triantafillidis JK.
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The Role of Gasdermin B-Mediated Pyroptosis in Bladder Cancer Diagnosis. [PDF]
Int J Mol SciPączek S +3 more
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Scientific ReportsGasdermin C is one of the least studied members of the gasdermin family of proteins, known for their critical involvement in pyroptosis and host defense.
Reyes Gámez-Belmonte +13 more
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Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases [PDF]
Cell Reports, 2021 Bowen Zhou, Derek W Abbott
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The Role of Pyroptosis in Colorectal Cancer: From Mechanisms to Therapeutic Opportunities. [PDF]
Cancer Manag ResHaiqing Xie, Xueting Deng, Quanpeng Li Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Quanpeng Li, Medical Center for Digestive Diseases, Second ...
Xie H, Deng X, Li Q.
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The Versatile Gasdermin Family: Their Function and Roles in Diseases
Frontiers in Immunology, 2021 The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess a C-terminal repressor domain, cytotoxic N-terminal domain, and flexible linker domain (except ...
Ju Zou +9 more
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Acta Pharmaceutica Sinica B, 2021 Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to induce strong inflammatory responses that defend the host against microbe infection. Excessive pyroptosis, however, leads to several inflammatory diseases, including sepsis and autoimmune disorders. Pyroptosis can be canonical or noncanonical.
Brandon E. Burdette +3 more
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Pyroptosis: shedding light on the mechanisms and links with cancers
Frontiers in Immunology, 2023 Pyroptosis, a novel form of programmed cell death (PCD) discovered after apoptosis and necrosis, is characterized by cell swelling, cytomembrane perforation and lysis, chromatin DNA fragmentation, and the release of intracellular proinflammatory contents,
Hong-mei You +5 more
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