Results 11 to 20 of about 16,670 (227)
Frontiers in Immunology, 2023 Sepsis is a hyper-heterogeneous syndrome in which the systemic inflammatory response persists throughout the course of the disease and the inflammatory and immune responses are dynamically altered at different pathogenic stages.
Wenhua Wang, Zhihui He, Zhihui He
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Acta Pharmaceutica Sinica B, 2021 Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to induce strong inflammatory responses that defend the host against microbe infection. Excessive pyroptosis, however, leads to several inflammatory diseases, including sepsis and autoimmune disorders. Pyroptosis can be canonical or noncanonical.
Brandon E. Burdette +3 more
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Gasdermin D and Beyond – Gasdermin-mediated Pyroptosis in Bacterial Infections
Journal of Molecular Biology, 2022 The discovery of pyroptosis and its subsequent implications in infection and immunity has uncovered a new angle of host-defence against pathogen assault. At its most simple, gasdermin-mediated pyroptosis in bacterial infection would be expected to remove pathogens from the relative safety of the cytosol or pathogen containing vacuole/phagosome whilst ...
Lee M, Booty, Clare E, Bryant
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Gasdermins: Effectors of Pyroptosis [PDF]
Trends in Cell Biology, 2017 Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect cytosolic contamination or perturbation. This drives activation of caspase-1 or caspase-11/4/5, which cleave gasdermin D, separating its N-terminal pore-forming domain (PFD) from the C-terminal repressor domain (RD).
Miao, Edward A., Kovacs, Stephen B.
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Cells, 2023 Psoriasis is a frequent and incurable skin disease whose pathogenesis is still not fully understood. It is characterized by immune disturbances leading to hyperproliferation and improper differentiation of keratinocytes.
Julia Nowowiejska +6 more
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Pyroptosis Modulators: New Insights of Gasdermins in Health and Disease
Antioxidants, 2023 Pyroptosis is an inflammation-dependent type of cell death that has been in the spotlight for the scientific community in the last few years. Crucial players in the process of pyroptosis are the members of the gasdermin family of proteins, which have ...
Imane Allali-Boumara +4 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on GSDMA (gasdermin A), with data on DNA, on the protein encoded, and where the gene is implicated.
Saeki, N, Sasaki, H
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Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy
Frontiers in Pharmacology, 2021 Pyroptosis is a recently identified type of lytic programmed cell death, in which pores form in the plasma membrane, and cells swell, rupture, and then release their contents, including inflammatory cytokines.
Wen Li +5 more
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Gasdermins against intracellular bacterial pathogens. [PDF]
Nat MicrobiolIntracellular bacterial pathogens can cause high levels of morbidity and mortality in humans. Host immune responses that protect against these infections include pyroptosis, a form of lytic cell death caused by the insertion of large gasdermin (GSDM) pores into the host plasma membrane.
Souza FW, Liu Y, Trujillo J, Miao EA.
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Pyroptosis- What We Know and the Road Ahead! [PDF]
Journal of Clinical and Diagnostic Research, 2022 Pyroptosis, a type of cell death, initiated by proinflammatory signals, is classically associated with inflammation. It was thought to occur mainly in macrophages and leukocytes during inflammatory conditions and involves the activation of caspase 1 ...
Anitha Krishnan Pandarathodiyil +3 more
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