Results 11 to 20 of about 21,414 (253)
Vastly different energy landscapes of the membrane insertions of monomeric gasdermin D and A3
Communications ChemistryGasdermin D and gasdermin A3 belong to the same family of pore-forming proteins and executors of pyroptosis, a form of programmed cell death. To unveil the process of their pore formation, we examine the energy landscapes upon insertion of the gasdermin ...
Viktoria Korn, Kristyna Pluhackova
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, 2022 Supplementary Figure from Raptinal Induces Gasdermin E–Dependent Pyroptosis in Naïve and Therapy-Resistant ...
Andrew E. Aplin (14940036) +7 more
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The Paradoxical Role of Pyroptosis in Gastrointestinal Cancers: From Molecular Mechanisms to Therapeutic Horizons [PDF]
BiomedicinesPyroptosis, a gasdermin-mediated and highly immunogenic form of regulated cell death, has surfaced as a critical determinant in the progression and therapeutic landscape of gastrointestinal (GI) cancers.
John K. Triantafillidis
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The Versatile Gasdermin Family: Their Function and Roles in Diseases
Frontiers in Immunology, 2021 The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess a C-terminal repressor domain, cytotoxic N-terminal domain, and flexible linker domain (except ...
Ju Zou +9 more
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Pyroptosis: shedding light on the mechanisms and links with cancers
Frontiers in Immunology, 2023 Pyroptosis, a novel form of programmed cell death (PCD) discovered after apoptosis and necrosis, is characterized by cell swelling, cytomembrane perforation and lysis, chromatin DNA fragmentation, and the release of intracellular proinflammatory contents,
Hong-mei You +5 more
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Research Progress of Pyroptosis in Alzheimer’s Disease
Frontiers in Molecular Neuroscience, 2022 Alzheimer’s disease (AD) is a disease characterized by insidious and progressive neurodegeneration, with clinical syndromes of memory and visuospatial skills damage.
Weiyue Xue, Di Cui, Ye Qiu
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Role of Pyroptosis in Inflammatory Bowel Disease (IBD): From Gasdermins to DAMPs
Frontiers in Pharmacology, 2022 Pyroptosis is a pro-inflammatory cell death executed by gasdermin family proteins that involve the formation of pores on cells, recognition of danger signals, and release of pro-inflammatory cytokines IL-1β and IL-18.
Shuxia Zhang +4 more
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Posttranslational and therapeutic control of gasdermin-mediated pyroptosis and inflammation [PDF]
, 2021 Pyroptosis is a proinflammatory form of cell death, mediated by membrane pore-forming proteins called gasdermins. Gasdermin pores allow the release of the pro-inflammatory cytokines IL-1β and IL-18 and cause cell swelling and cell lysis leading to ...
Chen, Kaiwen W. +5 more
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Role of Pyroptosis in Acetaminophen-Induced Hepatotoxicity
Livers, 2022 Acetaminophen (APAP) is a widely used pain reliever that can cause liver injury or liver failure in response to an overdose. Understanding the mechanisms of APAP-induced cell death is critical for identifying new therapeutic targets.
Hartmut Jaeschke +2 more
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Gasdermins assemble; recent developments in bacteriology and pharmacology
Frontiers in Immunology, 2023 The discovery of gasdermin D (GSDMD) as the terminal executioner of pyroptosis provided a large piece of the cell death puzzle, whilst simultaneously and firmly putting the gasdermin family into the limelight.
Claudine S. Greenwood +4 more
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