Results 21 to 30 of about 16,670 (227)
Methods for monitoring cancer cell pyroptosis
Cancer Biology & Medicine, 2022 Pyroptosis is a form of proinflammatory cell death that depends on the gasdermin family of proteins. The main features of pyroptosis are altered membrane permeability, cell swelling, membrane rupture, and the ability to mobilize a strong immune response.
Shuo Wang +3 more
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Role of pyroptosis in the pathogenesis and treatment of diseases
MedComm, 2023 Programmed cell death (PCD) is regarded as a pathological form of cell death with an intracellular program mediated, which plays a pivotal role in maintaining homeostasis and embryonic development.
Xiangyu Jin +3 more
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Gasdermins and their role in immunity and inflammation [PDF]
Journal of Experimental Medicine, 2019 The gasdermins are a family of pore-forming proteins recently implicated in the immune response. One of these proteins, gasdermin D (GSDMD), has been identified as the executioner of pyroptosis, an inflammatory form of lytic cell death that is induced upon formation of caspase-1–activating inflammasomes.
Pontus Orning +2 more
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Pyroptosis and Sarcopenia: Frontier Perspective of Disease Mechanism
Cells, 2022 With global ageing, sarcopenia, as an age-related disease, has brought a heavy burden to individuals and society. Increasing attention has been given to further exploring the morbidity mechanism and intervention measures for sarcopenia.
Hongfu Jin +5 more
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Frontiers in Immunology, 2022 BackgroundDuchenne muscular dystrophy (DMD) is the most common inherited human myopathy. Typically, the secondary process involving severe inflammation and necrosis exacerbate disease progression.
Nicolas Dubuisson +9 more
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Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors
eLife, 2022 The type VI secretion system (T6SS) is used by bacteria to deliver toxic effectors directly into target cells. Most T6SSs mediate antibacterial activities, whereas the potential anti-eukaryotic role of T6SS remains understudied.
Hadar Cohen +5 more
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Pyroptosis: Role and Mechanisms in Cardiovascular Disease
Frontiers in Cardiovascular Medicine, 2022 Cardiovascular disease (CVD) is a common disease that poses a huge threat to human health. Irreversible cardiac damage due to cardiomyocyte death and lack of regenerative capacity under stressful conditions, ultimately leading to impaired cardiac ...
Xinzhe Chen +4 more
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Evolution of the gasdermin family and pyroptosis
Developmental & Comparative Immunology, 2023 Gasdermins have been identified as playing a prominent role in the innate immune response as the executors of a specific type of cell death called pyroptosis. Specific proteolytic cleavage of gasdermins generates an N-terminal that oligomerizes and forms pores in the cell membrane.
Angosto-Bazarra, Diego +2 more
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Gasdermin D: A potential mediator and prognostic marker of bladder cancer
Frontiers in Molecular Biosciences, 2022 Background: Bladder cancer is considered one of the commonest widespread cancers, its presentation ranges from non-muscle invasive form to being muscle-invasive. The gasdermin family of proteins consists of six proteins.
Randa El-Gamal +6 more
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Sublytic gasdermin-D pores captured in atomistic molecular simulations
eLife, 2022 Gasdermin-D (GSDMD) is the ultimate effector of pyroptosis, a form of programmed cell death associated with pathogen invasion and inflammation. After proteolytic cleavage by caspases, the GSDMD N-terminal domain (GSDMDNT) assembles on the inner leaflet ...
Stefan L Schaefer, Gerhard Hummer
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