Results 21 to 30 of about 17,935 (273)
BMC Biology, 2022 Background Gasdermins are ancient (>500million-years-ago) proteins, constituting a family of pore-forming proteins that allow the release of intracellular content including proinflammatory cytokines.
Diego Angosto-Bazarra +5 more
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Research Progress of Pyroptosis in Alzheimer’s Disease
Frontiers in Molecular Neuroscience, 2022 Alzheimer’s disease (AD) is a disease characterized by insidious and progressive neurodegeneration, with clinical syndromes of memory and visuospatial skills damage.
Weiyue Xue, Di Cui, Ye Qiu
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Role of Pyroptosis in Inflammatory Bowel Disease (IBD): From Gasdermins to DAMPs
Frontiers in Pharmacology, 2022 Pyroptosis is a pro-inflammatory cell death executed by gasdermin family proteins that involve the formation of pores on cells, recognition of danger signals, and release of pro-inflammatory cytokines IL-1β and IL-18.
Shuxia Zhang +4 more
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Gasdermin D and Beyond – Gasdermin-mediated Pyroptosis in Bacterial Infections
Journal of Molecular Biology, 2022 The discovery of pyroptosis and its subsequent implications in infection and immunity has uncovered a new angle of host-defence against pathogen assault. At its most simple, gasdermin-mediated pyroptosis in bacterial infection would be expected to remove pathogens from the relative safety of the cytosol or pathogen containing vacuole/phagosome whilst ...
Lee M, Booty, Clare E, Bryant
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Role of Pyroptosis in Acetaminophen-Induced Hepatotoxicity
Livers, 2022 Acetaminophen (APAP) is a widely used pain reliever that can cause liver injury or liver failure in response to an overdose. Understanding the mechanisms of APAP-induced cell death is critical for identifying new therapeutic targets.
Hartmut Jaeschke +2 more
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Gasdermins: Effectors of Pyroptosis [PDF]
Trends in Cell Biology, 2017 Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect cytosolic contamination or perturbation. This drives activation of caspase-1 or caspase-11/4/5, which cleave gasdermin D, separating its N-terminal pore-forming domain (PFD) from the C-terminal repressor domain (RD).
Miao, Edward A., Kovacs, Stephen B.
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Gasdermins assemble; recent developments in bacteriology and pharmacology
Frontiers in Immunology, 2023 The discovery of gasdermin D (GSDMD) as the terminal executioner of pyroptosis provided a large piece of the cell death puzzle, whilst simultaneously and firmly putting the gasdermin family into the limelight.
Claudine S. Greenwood +4 more
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NLRP3 Inflammasome and Pyroptosis in Liver Pathophysiology: The Emerging Relevance of Nrf2 Inducers
Antioxidants, 2022 Inflammasomes, particularly the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain containing 3 (NLRP3) inflammasome, apparently serve as crucial regulators of the inflammatory response through the activation of Caspase-1 ...
Laura Hurtado-Navarro +4 more
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Cells, 2023 Psoriasis is a frequent and incurable skin disease whose pathogenesis is still not fully understood. It is characterized by immune disturbances leading to hyperproliferation and improper differentiation of keratinocytes.
Julia Nowowiejska +6 more
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Pyroptosis Modulators: New Insights of Gasdermins in Health and Disease
Antioxidants, 2023 Pyroptosis is an inflammation-dependent type of cell death that has been in the spotlight for the scientific community in the last few years. Crucial players in the process of pyroptosis are the members of the gasdermin family of proteins, which have ...
Imane Allali-Boumara +4 more
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