Results 21 to 30 of about 25,524 (331)
Targeting the NLRP3 Inflammasome-Gasdermin D Axis to Combat Cardiovascular Diseases.
Journal of Molecular and Cellular CardiologyCardiovascular disease remains a leading global cause of mortality, with inflammation playing a crucial role in driving its pathology. Despite advancements in cardiovascular disease management, current treatment options primarily address risk factors and
Judy S. Choi +4 more
semanticscholar +2 more sources
Pore-forming activity and structural autoinhibition of the gasdermin family
Nature, 2016 Jianjin Shi, Jingjin Ding
exaly +2 more sources
, 2022 Supplementary Figure from Raptinal Induces Gasdermin E–Dependent Pyroptosis in Naïve and Therapy-Resistant ...
Andrew E. Aplin (14940036) +7 more
core +7 more sources
Frontiers in Immunology, 2023 Sepsis is a hyper-heterogeneous syndrome in which the systemic inflammatory response persists throughout the course of the disease and the inflammatory and immune responses are dynamically altered at different pathogenic stages. Gasdermins (GSDMs) proteins are pore-forming executors in the membrane, subsequently mediating the release of pro ...
Wenhua Wang, Zhihui He, Zhihui He
openaire +3 more sources
Pyroptosis: shedding light on the mechanisms and links with cancers
Frontiers in Immunology, 2023 Pyroptosis, a novel form of programmed cell death (PCD) discovered after apoptosis and necrosis, is characterized by cell swelling, cytomembrane perforation and lysis, chromatin DNA fragmentation, and the release of intracellular proinflammatory contents,
Hong-mei You +5 more
doaj +1 more source
Research Progress of Pyroptosis in Alzheimer’s Disease
Frontiers in Molecular Neuroscience, 2022 Alzheimer’s disease (AD) is a disease characterized by insidious and progressive neurodegeneration, with clinical syndromes of memory and visuospatial skills damage.
Weiyue Xue, Di Cui, Ye Qiu
doaj +1 more source
Role of Pyroptosis in Inflammatory Bowel Disease (IBD): From Gasdermins to DAMPs
Frontiers in Pharmacology, 2022 Pyroptosis is a pro-inflammatory cell death executed by gasdermin family proteins that involve the formation of pores on cells, recognition of danger signals, and release of pro-inflammatory cytokines IL-1β and IL-18.
Shuxia Zhang +4 more
doaj +1 more source
Gasdermin D and Beyond – Gasdermin-mediated Pyroptosis in Bacterial Infections
Journal of Molecular Biology, 2022 The discovery of pyroptosis and its subsequent implications in infection and immunity has uncovered a new angle of host-defence against pathogen assault. At its most simple, gasdermin-mediated pyroptosis in bacterial infection would be expected to remove pathogens from the relative safety of the cytosol or pathogen containing vacuole/phagosome whilst ...
Lee M, Booty, Clare E, Bryant
openaire +2 more sources
Posttranslational and therapeutic control of gasdermin-mediated pyroptosis and inflammation [PDF]
, 2021 Pyroptosis is a proinflammatory form of cell death, mediated by membrane pore-forming proteins called gasdermins. Gasdermin pores allow the release of the pro-inflammatory cytokines IL-1β and IL-18 and cause cell swelling and cell lysis leading to ...
Chen, Kaiwen W. +5 more
core +1 more source
Role of Pyroptosis in Acetaminophen-Induced Hepatotoxicity
Livers, 2022 Acetaminophen (APAP) is a widely used pain reliever that can cause liver injury or liver failure in response to an overdose. Understanding the mechanisms of APAP-induced cell death is critical for identifying new therapeutic targets.
Hartmut Jaeschke +2 more
doaj +1 more source