Results 21 to 30 of about 21,414 (253)
NLRP3 Inflammasome and Pyroptosis in Liver Pathophysiology: The Emerging Relevance of Nrf2 Inducers
Antioxidants, 2022 Inflammasomes, particularly the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain containing 3 (NLRP3) inflammasome, apparently serve as crucial regulators of the inflammatory response through the activation of Caspase-1 ...
Laura Hurtado-Navarro +4 more
doaj +1 more source
Cells, 2023 Psoriasis is a frequent and incurable skin disease whose pathogenesis is still not fully understood. It is characterized by immune disturbances leading to hyperproliferation and improper differentiation of keratinocytes.
Julia Nowowiejska +6 more
doaj +1 more source
Pyroptosis Modulators: New Insights of Gasdermins in Health and Disease
Antioxidants, 2023 Pyroptosis is an inflammation-dependent type of cell death that has been in the spotlight for the scientific community in the last few years. Crucial players in the process of pyroptosis are the members of the gasdermin family of proteins, which have ...
Imane Allali-Boumara +4 more
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Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy
Frontiers in Pharmacology, 2021 Pyroptosis is a recently identified type of lytic programmed cell death, in which pores form in the plasma membrane, and cells swell, rupture, and then release their contents, including inflammatory cytokines.
Wen Li +5 more
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Regulation of Lytic and Non-Lytic Functions of Gasdermin Pores.
, 2022 Pyroptosis is a necrotic form of cell death that was initially found to be induced upon activation of inflammatory caspases by inflammasome complexes.
Broz, P. +3 more
core +1 more source
, 2011 Review on GSDMA (gasdermin A), with data on DNA, on the protein encoded, and where the gene is ...
Sasaki, H, Saeki, N
core +1 more source
Unconventional protein secretion by gasdermin pores
, 2023 Unconventional protein secretion (UPS) allows the release of specific leaderless proteins independently of the classical endoplasmic reticulum (ER)-Golgi secretory pathway.
Broz, P., Petr Broz
core +1 more source
Methods for monitoring cancer cell pyroptosis
Cancer Biology & Medicine, 2022 Pyroptosis is a form of proinflammatory cell death that depends on the gasdermin family of proteins. The main features of pyroptosis are altered membrane permeability, cell swelling, membrane rupture, and the ability to mobilize a strong immune response.
Shuo Wang +3 more
doaj +1 more source
Pyroptosis- What We Know and the Road Ahead! [PDF]
Journal of Clinical and Diagnostic Research, 2022 Pyroptosis, a type of cell death, initiated by proinflammatory signals, is classically associated with inflammation. It was thought to occur mainly in macrophages and leukocytes during inflammatory conditions and involves the activation of caspase 1 ...
Anitha Krishnan Pandarathodiyil +3 more
doaj +1 more source
, 2012 Review on GSDMB (gasdermin B), with data on DNA, on the protein encoded, and where the gene is ...
Tamura, M, Shiroishi, T
core +1 more source