Results 31 to 40 of about 47,718 (166)

HMGB1 mediates lipopolysaccharide-induced macrophage autophagy and pyroptosis

BMC Molecular and Cell Biology, 2023
Autophagy and pyroptosis of macrophages play important protective or detrimental roles in sepsis. However, the underlying mechanisms remain unclear.
Jiawei Shang, Feng Zhao, Yongmei Cao, Feng Ping, Wei Wang, Yingchuan Li   +5 more
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The Molecular Pathways of Pyroptosis in Atherosclerosis [PDF]

Frontiers in Cell and Developmental Biology, 2022
Atherosclerosis (AS) is a chronic inflammatory disease seriously endangering human health, whose occurrence and development is related to many factors. Pyroptosis is a recently identified novel programmed cell death associated with an inflammatory response and involved in the formation and progression of AS by activating different signaling pathways ...
Dan Song, Manman Li, Xue Yu, Yuqin Wang, Jiaying Fan, Wei Yang, Liming Yang, Hong Li   +7 more
openaire   +3 more sources

Comprehensive Characterization of Pyroptosis Patterns with Implications in Prognosis and Immunotherapy in Low-Grade Gliomas

Frontiers in Genetics, 2022
Background: Due to high heterogeneity and mortality of low-grade gliomas (LGGs), it is of great significance to find biomarkers for prognosis and immunotherapy.
Zijian Zhou, Jinhong Wei, Bin Lu, Wenbo Jiang, Yue Bao, Luo Li, Weimin Wang   +6 more
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Reactive Oxygen Species‐Mediated Pyroptosis with the Help of Nanotechnology: Prospects for Cancer Therapy

Advanced NanoBiomed Research, 2023
Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two main reasons for the poor outcomes of tumor treatment. Pyroptosis is a newly discovered form of programmed cell death, featuring surprising proinflammatory activity ...
Yuan Ding, Binglin Ye, Zhongquan Sun, Zhengwei Mao, Weilin Wang   +4 more
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Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats

Mediators of Inflammation, 2023
Background. Peripheral nerve injury (PNI) is one of the most debilitating injuries, but therapies for PNI are still far from satisfactory. Pyroptosis, a recently identified form of cell death, has been demonstrated to participate in different diseases ...
Jiayi Wang, Shunyi Lu, Ya Yuan, Lei Huang, Mengxuan Bian, Jieqin Yu, Jiapeng Zou, Libo Jiang, Dehua Meng, Jian Zhang   +9 more
doaj   +1 more source

Analysis of Pyroptosis-Related Immune Signatures and Identification of Pyroptosis-Related LncRNA Prognostic Signature in Clear Cell Renal Cell Carcinoma

Frontiers in Genetics, 2022
Clear cell renal cell carcinoma (ccRCC) is a common urinary system malignant tumor with a high incidence and recurrence rate. Pyroptosis is a kind of programmed cell death caused by inflammasomes.
Ming Zhong, Xiaohua Wang, Enyi Zhu, Lian Gong, Lingyan Fei, Liang Zhao, Keping Wu, Chun Tang, Lizhen Zhang, Zhongli Wang, Zhihua Zheng   +10 more
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Uromodulin, Inflammasomes, and Pyroptosis [PDF]

Journal of the American Society of Nephrology, 2012
As a kidney-specific protein, uromodulin has fascinated nephrologists for decades.[1][1] Initially known as Tamm-Horsfall protein, uromodulin is secreted by distal tubules into the urine, where it is the most abundant protein under physiologic conditions.
Maria Dolores, Sanchez-Niño, Ana B, Sanz, Alberto, Ortiz   +2 more
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Pyroptosis as a candidate therapeutic target for Alzheimer’s disease

Frontiers in Aging Neuroscience, 2022
Pyroptosis is a form of cell death mediated by inflammasomes and gasdermins, and the relevance of pyroptosis to neurodegenerative diseases is currently receiving increasing attention.
Yuehua Huang, Yuehua Huang, Xiaoyu Li, Guifei Luo, Guifei Luo, Junli Wang, Junli Wang, Ranhui Li, Chuyi Zhou, Teng Wan, Fenglian Yang   +10 more
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Identification of pyroptosis-related subtypes and comprehensive analysis of characteristics of the tumor microenvironment infiltration in clear cell renal cell carcinoma

Scientific Reports, 2023
Pyroptosis is a kind of programmed cell death triggered by the inflammasome. Growing evidence has revealed the crucial utility of pyroptosis in tumors.
Jiayi Zeng, Ping Zhu, Yanlin Tang, Changzheng Zhang, Chujin Ye, Shouyu Cheng, Kaiwen Tian, Bowen Yang, Weinan Zeng, Yanjun Liu, Zhiyong Xian, Yuming Yu   +11 more
doaj   +1 more source

Research progress on pyroptosis regulated by mesenchymal stem cell-derived exosomes

Frontiers in Immunology
Pyroptosis is a newly discovered form of inflammatory programmed cell death, which is frequently involved in the occurrence and development of various diseases.
Tingyu Yang, Jiapan An, Xinqi Xu, Bin Li, Bin Li, Zhimin Dou, Zhimin Dou   +6 more
doaj   +1 more source