Results 31 to 40 of about 6,483 (210)
HMGB1 mediates lipopolysaccharide-induced macrophage autophagy and pyroptosis
BMC Molecular and Cell Biology, 2023 Autophagy and pyroptosis of macrophages play important protective or detrimental roles in sepsis. However, the underlying mechanisms remain unclear.
Jiawei Shang +5 more
doaj +1 more source
Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats
Mediators of Inflammation, 2023 Background. Peripheral nerve injury (PNI) is one of the most debilitating injuries, but therapies for PNI are still far from satisfactory. Pyroptosis, a recently identified form of cell death, has been demonstrated to participate in different diseases ...
Jiayi Wang +9 more
doaj +1 more source
Frontiers in Genetics, 2022 Background: Due to high heterogeneity and mortality of low-grade gliomas (LGGs), it is of great significance to find biomarkers for prognosis and immunotherapy.
Zijian Zhou +6 more
doaj +1 more source
The Molecular Pathways of Pyroptosis in Atherosclerosis [PDF]
Frontiers in Cell and Developmental Biology, 2022 Atherosclerosis (AS) is a chronic inflammatory disease seriously endangering human health, whose occurrence and development is related to many factors. Pyroptosis is a recently identified novel programmed cell death associated with an inflammatory response and involved in the formation and progression of AS by activating different signaling pathways ...
Dan Song +7 more
openaire +3 more sources
Advanced NanoBiomed Research, 2023 Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two main reasons for the poor outcomes of tumor treatment. Pyroptosis is a newly discovered form of programmed cell death, featuring surprising proinflammatory activity ...
Yuan Ding +4 more
doaj +1 more source
Frontiers in Genetics, 2022 Clear cell renal cell carcinoma (ccRCC) is a common urinary system malignant tumor with a high incidence and recurrence rate. Pyroptosis is a kind of programmed cell death caused by inflammasomes.
Ming Zhong +10 more
doaj +1 more source
Pyroptosis Induction and Detection [PDF]
Current Protocols in Immunology, 2018 AbstractPyroptosis is a form of programmed pro‐inflammatory cell death that plays a protective role in the host response to infection, but can also promote pathogenic inflammation. Pyroptosis is mediated by the cysteine protease, caspase‐1. Caspase‐1 cleaves gasdermin D, releasing the N‐terminal pore‐forming domain, which inserts into the plasma ...
Andreas B, den Hartigh, Susan L, Fink
openaire +2 more sources
Oncotarget, 2015 Pyroptosis is a form of inflammatory cell death mediated by inflammatory caspases. Two independent studies have recently demonstrated that inflammatory caspases cleave gasdermin D and the resulting N-terminal fragment of this protein mediates pyroptosis. Here we summarize the key findings reported in these important publications.
Yoon, Lim, Sharad, Kumar
openaire +2 more sources
Approaching Neutrophil Pyroptosis
Journal of Molecular Biology, 2022 All cells must die at some point, and the dogma is that they do it either silently via apoptosis or via pro-inflammatory, lytic forms of death. Amongst these lytic cell death pathways, pyroptosis is one of the best characterized. Pyroptosis depends on inflammatory caspases which activate members of the gasdermin family of proteins, and it is associated
openaire +4 more sources
Pyroptosis as a candidate therapeutic target for Alzheimer’s disease
Frontiers in Aging Neuroscience, 2022 Pyroptosis is a form of cell death mediated by inflammasomes and gasdermins, and the relevance of pyroptosis to neurodegenerative diseases is currently receiving increasing attention.
Yuehua Huang +10 more
doaj +1 more source