Results 51 to 60 of about 47,718 (166)
Frontiers in Immunology, 2022 AimThis study aims to identify pyroptosis-related genes (PRGs), their functional immune characteristics, and distinct pyroptosis-related clusters in periodontitis.MethodsDifferentially expressed (DE)-PRGs were determined by merging the expression ...
Wanchen Ning +4 more
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Pyroptosis in Steatohepatitis and Liver Diseases
Journal of Molecular Biology, 2022 Pyroptosis is an inflammatory form of regulated cell death, which functions in the clearance of intracellularly replicating pathogens by cell lysis in order to induce further immune response. Since the discovery of the gasdermin (GSDM) family, pyroptosis has attracted attention in a wide range of inflammatory diseases such as nonalcoholic ...
Jana, Knorr +2 more
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BMC Musculoskeletal Disorders, 2023 Purpose Steroid-induced necrosis of the femoral head (SONFH) is a refractory orthopedic hip disease occurring in young and middle-aged people, with glucocorticoids being the most common cause. Previous experimental studies have shown that cell pyroptosis
Jin-Lian Chai +5 more
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Pyroptosis in Antiviral Immunity
, 2019 Pyroptosis is a form of lytic, programmed cell death that functions as an innate immune effector mechanism to facilitate host defense against pathogenic microorganisms, including viruses. This type of proinflammatory cell death is orchestrated by proteolytic activation of human or mouse caspase-1, mouse caspase-11 and human caspase-4 and caspase-5 in ...
Teneema, Kuriakose +1 more
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Journal of Dental SciencesBackground/purpose: Promoting osteogenesis under inflammatory conditions holds promise for preventing and mitigating peri-implantitis. Cell pyroptosis inhibits osteoblast-mediated bone formation.
Hui-Min Wang +6 more
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SGLT2 inhibition attenuates diabetic tubulopathy by suppressing SGK1-mediated pyroptosis
Frontiers in EndocrinologyBackgroundDiabetic tubulopathy is increasingly recognized as a pivotal contributor to diabetic kidney disease (DKD) progression. Excessive pyroptosis of renal tubular epithelial cells exacerbates inflammation and tissue injury.
Xu Shi +20 more
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ROS induced pyroptosis in inflammatory disease and cancer
Frontiers in ImmunologyPyroptosis, a form of caspase-1-dependent cell death, also known as inflammation-dependent death, plays a crucial role in diseases such as stroke, heart disease, or tumors. Since its elucidation, pyroptosis has attracted widespread attention from various
Jingsong Wang +5 more
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Embryo‐Derived Cathepsin B Promotes Implantation and Decidualization by Activating Pyroptosis
Advanced ScienceEmbryo implantation and decidualization are crucial for a successful pregnancy. How the inflammatory response is regulated during these processes is undefined. Pyroptosis is an inflammatory form of cell death mediated by gasdermin D (GSDMD).
Meng‐Yuan Li +7 more
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Induction of Pyroptosis and Its Implications in Cancer Management
Frontiers in Oncology, 2019 Pyroptosis is a gasdermins mediated programmed cell death, which has been widely studied in inflammatory disease models. Recently, there are growing evidences that pyroptosis can be chemically induced in cancer cells without any bacterial or viral ...
Yan-Yang Wang +4 more
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Triggering Pyroptosis in Cancer
BiomoleculesPyroptosis is an inflammatory programmed cell death recently identified as a crucial cellular process in various diseases, including cancers. Unlike other forms of cell death, canonical pyroptosis involves the specific cleavage of gasdermin by caspase-1, resulting in cell membrane damage and the release of the pro-inflammatory cytokines IL-1β and IL-18.
Daniel E. Johnson, Zhibin Cui
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