Results 41 to 50 of about 67,070 (304)

Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats

Mediators of Inflammation, 2023
Background. Peripheral nerve injury (PNI) is one of the most debilitating injuries, but therapies for PNI are still far from satisfactory. Pyroptosis, a recently identified form of cell death, has been demonstrated to participate in different diseases ...
Jiayi Wang, Shunyi Lu, Ya Yuan, Lei Huang, Mengxuan Bian, Jieqin Yu, Jiapeng Zou, Libo Jiang, Dehua Meng, Jian Zhang   +9 more
doaj   +1 more source

Comprehensive Characterization of Pyroptosis Patterns with Implications in Prognosis and Immunotherapy in Low-Grade Gliomas

Frontiers in Genetics, 2022
Background: Due to high heterogeneity and mortality of low-grade gliomas (LGGs), it is of great significance to find biomarkers for prognosis and immunotherapy.
Zijian Zhou, Jinhong Wei, Bin Lu, Wenbo Jiang, Yue Bao, Luo Li, Weimin Wang   +6 more
doaj   +1 more source

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. [PDF]

, 2017
Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis.
Alnemri, Diana, Alnemri, Emad S., Cingolani, Gino, Fernandes-Alnemri, Teresa, Mayes, Lindsey, Rogers, Corey   +5 more
core   +2 more sources

HMGB1 mediates lipopolysaccharide-induced macrophage autophagy and pyroptosis

BMC Molecular and Cell Biology, 2023
Autophagy and pyroptosis of macrophages play important protective or detrimental roles in sepsis. However, the underlying mechanisms remain unclear.
Jiawei Shang, Feng Zhao, Yongmei Cao, Feng Ping, Wei Wang, Yingchuan Li   +5 more
doaj   +1 more source

Defusing inflammasomes. [PDF]

, 2018
In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation.
Sandstrom, Andrew, VANCE, Russell E.
core   +1 more source

Reactive Oxygen Species‐Mediated Pyroptosis with the Help of Nanotechnology: Prospects for Cancer Therapy

Advanced NanoBiomed Research, 2023
Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two main reasons for the poor outcomes of tumor treatment. Pyroptosis is a newly discovered form of programmed cell death, featuring surprising proinflammatory activity ...
Yuan Ding, Binglin Ye, Zhongquan Sun, Zhengwei Mao, Weilin Wang   +4 more
doaj   +1 more source

Analysis of Pyroptosis-Related Immune Signatures and Identification of Pyroptosis-Related LncRNA Prognostic Signature in Clear Cell Renal Cell Carcinoma

Frontiers in Genetics, 2022
Clear cell renal cell carcinoma (ccRCC) is a common urinary system malignant tumor with a high incidence and recurrence rate. Pyroptosis is a kind of programmed cell death caused by inflammasomes.
Ming Zhong, Xiaohua Wang, Enyi Zhu, Lian Gong, Lingyan Fei, Liang Zhao, Keping Wu, Chun Tang, Lizhen Zhang, Zhongli Wang, Zhihua Zheng   +10 more
doaj   +1 more source

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources

Pyroptosis Induction and Detection [PDF]

Current Protocols in Immunology, 2018
AbstractPyroptosis is a form of programmed pro‐inflammatory cell death that plays a protective role in the host response to infection, but can also promote pathogenic inflammation. Pyroptosis is mediated by the cysteine protease, caspase‐1. Caspase‐1 cleaves gasdermin D, releasing the N‐terminal pore‐forming domain, which inserts into the plasma ...
Andreas B, den Hartigh, Susan L, Fink
openaire   +2 more sources

Pyroptosis in Pulpitis

Journal of Inflammation Research
Pulpitis is an inflammatory disease occurs in the pulp tissues. Continuous development of pulpitis can lead to apical periodontitis and seriously damage the function of teeth, affecting the oral health and daily life of patients. Pyroptosis, alternatively termed inflammatory necrosis, is a type of programmed cell death that is characterized by the ...
Wei, Xiaorui, Ran, Shidian, Yan, Xingrui, Huang, Jindie, Xue, Linyu, He, Tong-Chuan, Zhang, Hongmei, Wu, Si   +7 more
openaire   +4 more sources