Results 41 to 50 of about 47,718 (166)

GAS5-inhibited hepatocyte pyroptosis contributes to hepatic stellate cell inactivation via microRNA-684 and AHR

iScience, 2023
Summary: Hepatocyte pyroptosis has been shown to be involved in liver damage progression. Previously, we found that growth arrest-specific 5 (GAS5) is a regulator of hepatic stellate cell (HSC) activation. However, whether GAS5 plays a role in hepatocyte
Zhichao Lang, Rongrong Zhang, Xinmiao Li, Yan Jin, Yuhang Hu, Xinyi Lin, Yunzhi Tang, Jingnan Zhang, Lei Zheng, Zhixian Yu, Jianjian Zheng   +10 more
doaj   +1 more source

Attenuates reactive oxygen species: induced pyroptosis via activation of the Nrf2/HO-1 signal pathway in models of trigeminal neuralgia

Scientific Reports, 2023
In this study, we examined the impact of demyelinating and neuroinflammation on trigeminal neuralgia (TN) by utilizing models of chronic constriction injury to the infraorbital nerve (CCI).
Mingxing Liu, Yongyi Wang, Shengli Li, Xiaoqun Hou, Tong Li, Zhiming Xu, Feng Chen, Yong Zhou, Lei Xia, Weimin Wang   +9 more
doaj   +1 more source

Regulation of Pyroptosis by ncRNA: A Novel Research Direction

Frontiers in Cell and Developmental Biology, 2022
Pyroptosis is a novel form of programmed cell death (PCD), which is characterized by DNA fragmentation, chromatin condensation, cell swelling and leakage of cell contents.
Liyuan Gao, Zhitao Jiang, Yi Han, Yang Li, Xiang Yang   +4 more
doaj   +1 more source

Pyroptosis‐Inducing Biomaterials Pave the Way for Transformative Antitumor Immunotherapy

Advanced Science
Pyroptosis can effectively overcome immunosuppression and reactivate antitumor immunity. However, pyroptosis initiation is challenging. First, the underlying biological mechanisms of pyroptosis are complex, and a variety of gasdermin family proteins can ...
Hao Yin, Tanzhou Chen, Xiaoqu Hu, Wenting Zhu, Yida Li, Wenjie Sun, Lei Li, Hongmei Zhang, Qinyang Wang   +8 more
doaj   +1 more source

Pathogenic effects of inhibition of mTORC1/STAT3 axis facilitates Staphylococcus aureus-induced pyroptosis in human macrophages

Cell Communication and Signaling, 2020
Background Pyroptosis is a recently identified pathway of caspase-mediated cell death in response to microbes, lipopolysaccharide, or chemotherapy in certain types of cells.
Ruiyuan Yao, Yuhao Chen, Huifang Hao, Zhixin Guo, Xiaoou Cheng, Yuze Ma, Qiang Ji, Xiaoru Yang, Yanfeng Wang, Xihe Li, Zhigang Wang   +10 more
doaj   +1 more source

Pyroptosis in liver disease

Revista Española de Enfermedades Digestivas, 2020
Pyroptosis is an inflammatory cell death process that is dependent on caspase. Pyroptosis is a specific form of programmed cell death with the morphological characteristics of formation of pores on the cell membrane, cell swelling, and rupture of the plasma membrane.
Lijuan, Zhang, Wang, Zeyu, Binghua, Liu, Shihe, Jang, Zhiguang, Zhang, Yong, Jiang   +5 more
openaire   +2 more sources

The role of pyroptosis in cognitive impairment

Frontiers in Neuroscience, 2023
Cognitive impairment is a major global disease, manifests as a decline in cognitive functioning and endangers the health of the population worldwide. The incidence of cognitive impairment has increased rapidly with an increasingly aging population.
Xin Yang, Zhe Tang
openaire   +3 more sources

The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases

Cell Death Discovery, 2022
Pyroptosis is a controlled form of inflammatory cell death characterized by inflammasome activation, pore formation, and cell lysis. According to different caspases, pyroptosis can be divided into canonical, non-canonical, and other pathways. The role of
Siyu Wang, Hua Wang, Chengyao Feng, Chenbei Li, Zhihong Li, Jieyu He, Chao Tu   +6 more
doaj   +1 more source

A single cut to pyroptosis

Oncotarget, 2015
Pyroptosis is a form of inflammatory cell death mediated by inflammatory caspases. Two independent studies have recently demonstrated that inflammatory caspases cleave gasdermin D and the resulting N-terminal fragment of this protein mediates pyroptosis. Here we summarize the key findings reported in these important publications.
Yoon, Lim, Sharad, Kumar
openaire   +2 more sources

Pyroptosis and Airway Homeostasis Regulation

Physiological Research, 2023
Pyroptosis is a form of cell death associated with inflammation. In the maintenance of airway homeostasis, pyroptosis goes through activation and assembly of Inflammasome. The pyroptosis pathway is mediated by caspase which activates the pore-forming effect of substrate gasdermin family members.
P, Xu, F, Li, H, Tang
openaire   +2 more sources