Results 61 to 70 of about 47,718 (166)

Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer

Journal for ImmunoTherapy of Cancer
Background Despite advancements in treatment modalities, several patients with colorectal cancer (CRC) remain unresponsive to immune checkpoint inhibitor therapy.
Tao Zhang, Jing Zhang, Lei Zhao, Jinghua Ren, Zhenyu Lin, Pengfei Zhou, Dejun Zhang, Dandan Yu, Lisha Li, Diwei Zhou, Yuanhang Yu, Peiyi Zhang, Jinge Zheng   +12 more
doaj   +1 more source

Mechanisms of pyroptosis in vitiligo

Tissue and Cell
Vitiligo is a common depigmentation disorder characterized by the loss of skin pigmentation, resulting in white patches on the skin. The pathogenesis of vitiligo involves complex interactions between genetic, immunological and environmental factors.
Yingying, Geng, Pengfei, Huang, Tingting, Cui   +2 more
openaire   +2 more sources

Harnessing Pyroptosis for Cancer Immunotherapy

Cells
Cancer immunotherapy is a novel pillar of cancer treatment that harnesses the immune system to fight tumors and generally results in robust antitumor immunity.
Christopher M. Bourne, Cornelius Y. Taabazuing   +1 more
doaj   +1 more source

Size-dependent pyroptosis induction by calcium oxalate monohydrate crystals in HK-2 cells

iScience
Summary: This article explored the differences in pyroptosis mediated by calcium oxalate monohydrate (COM) crystals with sizes of 100 nm, 1 μm, 3 μm, 5 μm, and 10 μm and were used to induce pyroptosis of HK-2 cells. The proportion of pyroptosis cells was
Xue-Wu Chen, Xin-Yi Tong, Run-Min Tan, Jian-Ming Ouyang   +3 more
doaj   +1 more source

Manipulation of cancer cell pyroptosis for therapeutic approaches: challenges and opportunities

Biomarker Research
Remarkable advances have been achieved following discoveries that gasdermins are the executioners of pyroptosis. The pyroptotic process consists a subcellular permeabilization phase and a cell lysis phase, the latter of which is irreversible.
Rui Miao, Xueying Wang, Jingyv Zhang, Qinyv Kang, Qing Liu, Xianglin Luo, Junwei Hou, Baorong Gao   +7 more
doaj   +1 more source

Pyroptosis, gasdermins and allergic diseases

Allergy
AbstractPyroptosis is an inflammatory form of programmed cell death that is distinct from necrosis and apoptosis. Pyroptosis is primarily mediated by the gasdermin family of proteins (GSDMA‐E and PVJK), which, when activated by proteolytic cleavage, form pores in the plasma membrane, leading to cell death.
Ronald Allan Panganiban, Kari C. Nadeau, Quan Lu   +2 more
openaire   +2 more sources

The role of pyroptosis in ovarian cancer

Discover Oncology
Pyroptosis is a novel form of programmed cell death that depends on gasdermin-mediated pore formation in the plasma membrane and the release of inflammatory factors. Pyroptosis is closely linked to the occurrence and progression of almost all types of cancer, including ovarian cancer, which is the seventh most common malignancy among women worldwide ...
Zhou, Yingzhi, Peng, Tian, Zhang, Jiahan, Liang, Ruojia   +3 more
openaire   +2 more sources

Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats

Translational Psychiatry
Melatonin improves chronic stress-induced hippocampal damage and depression-like behaviors, but the mechanism needs further study. This study was to explore the mechanism of melatonin inhibiting microglia pyroptosis.
Zhicheng Gao, Kangxin Luo, Yulin Hu, Yunqian Niu, Xinchao Zhu, Shoujun Li, Haiyang Zhang   +6 more
doaj   +1 more source

Pyroptosis [PDF]

, 2020
openaire   +1 more source

Corynebacterium pseudotuberculosis phospholipase D targets mitochondrial sphingomyelin and induces NLRP3-GSDMD axis-mediated pyroptosis in macrophages to promote infection

Veterinary Research
Infection by Corynebacterium pseudotuberculosis (Cp), a facultative intracellular bacterium, causes mainly purulent inflammation and chronic granulomas in animals and humans. Pyroptosis is a proinflammatory form of programmed cell death that is important
Xincan Li, Hong Lv, Chanyu Wu, Hexian Li, Wenyi Yi, Xiaoxin Niu, Qiuyue Peng, Chi Meng, Yongfeng Yuan, Shangquan Tian, Zhiying Wang, Rendong Fang, Zuoyong Zhou   +12 more
doaj   +1 more source